Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Mary F, Kearney"'
Autor:
Abigail A. Lilak, David B. Pecor, Graham Matulis, Alexander M. Potter, Rachel N. Wofford, Mary F. Kearney, Stephanie Mitchell, Fatima Jaradat, Arisa Kano, Dawn M. Zimmerman, James M. Hassell, Bersissa Kumsa, Maureen Kamau, Yvonne-Marie Linton, Michael E. von Fricken
Publikováno v:
Parasites & Vectors, Vol 17, Iss 1, Pp 1-28 (2024)
Abstract Background Surveillance data documenting tick and tick-borne disease (TBD) prevalence is needed to develop risk assessments and implement control strategies. Despite extensive research in Africa, there is no standardized, comprehensive revie
Externí odkaz:
https://doaj.org/article/cb5fb091b3044d9aa3cedeafea87eb7c
Autor:
Yury V. Kuzmichev, Carol Lackman-Smith, Sonia Bakkour, Ann Wiegand, Michael J. Bale, Andrew Musick, Wendy Bernstein, Naomi Aronson, Julie Ake, Sodsai Tovanabutra, Mars Stone, Roger G. Ptak, Mary F. Kearney, Michael P. Busch, Elizabeth R. Wonderlich, Deanna A. Kulpa
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The advent of combined antiretroviral therapy (cART) has been instrumental in controlling HIV-1 replication and transmission and decreasing associated morbidity and mortality. However, cART alone is not able to cure HIV-1 due to the presence
Externí odkaz:
https://doaj.org/article/545480fa87244f56b8e17d09e2796b5a
Autor:
Johannes C. Botha, Dimiter Demirov, Carli Gordijn, Mary Grace Katusiime, Michael J. Bale, Xiaolin Wu, Daria Wells, Stephen H. Hughes, Mark F. Cotton, John W. Mellors, Mary F. Kearney, Gert U. van Zyl
Publikováno v:
mBio, Vol 14, Iss 4 (2023)
ABSTRACT Combination antiretroviral therapy (cART) suppresses viral replication but does not cure HIV infection because a reservoir of infectious (intact) HIV proviruses persists in long-lived CD4+T cells. However, a large majority (>95%) of HIV-infe
Externí odkaz:
https://doaj.org/article/d5d9f7ebe1244d2c9af51df313d4cec7
Publikováno v:
Viruses, Vol 16, Iss 1, p 108 (2024)
The principal barrier to an HIV-1 cure is the persistence of infected cells harboring replication-competent proviruses despite antiretroviral therapy (ART). HIV-1 transcriptional suppression, referred to as viral latency, is foremost among persistenc
Externí odkaz:
https://doaj.org/article/f40b23e4ed8741b5894d6df536a918af
Autor:
Imogen A. Wright, Michael J. Bale, Wei Shao, Wei-Shau Hu, John M. Coffin, Gert U. Van Zyl, Mary F. Kearney
Publikováno v:
Retrovirology, Vol 18, Iss 1, Pp 1-6 (2021)
Abstract The characterisation of the HIV-1 reservoir, which consists of replication-competent integrated proviruses that persist on antiretroviral therapy (ART), is made difficult by the rarity of intact proviruses relative to those that are defectiv
Externí odkaz:
https://doaj.org/article/f0403fb048314b8bad0786d7ae4c20b2
Autor:
John M Coffin, Michael J Bale, Daria Wells, Shuang Guo, Brian Luke, Jennifer M Zerbato, Michele D Sobolewski, Twan Sia, Wei Shao, Xiaolin Wu, Frank Maldarelli, Mary F Kearney, John W Mellors, Stephen H Hughes
Publikováno v:
PLoS Pathogens, Vol 17, Iss 4, p e1009141 (2021)
HIV persists during antiretroviral therapy (ART) as integrated proviruses in cells descended from a small fraction of the CD4+ T cells infected prior to the initiation of ART. To better understand what controls HIV persistence and the distribution of
Externí odkaz:
https://doaj.org/article/3e177632677e4f3b9ab7e952f1029063
Autor:
Michael J. Bale, Mary Grace Katusiime, Daria Wells, Xiaolin Wu, Jonathan Spindler, Elias K. Halvas, Joshua C. Cyktor, Ann Wiegand, Wei Shao, Mark F. Cotton, Stephen H. Hughes, John W. Mellors, John M. Coffin, Gert U. Van Zyl, Mary F. Kearney
Publikováno v:
mBio, Vol 12, Iss 2 (2021)
HIV-1 integrates its genome into the DNA of host cells. Consequently, HIV-1 genomes are copied with the host cell DNA during cellular division.
Externí odkaz:
https://doaj.org/article/24168db87d274281ba8cf37cddd5815b
Autor:
Yuta Hikichi, Rachel Van Duyne, Phuong Pham, Jennifer L. Groebner, Ann Wiegand, John W. Mellors, Mary F. Kearney, Eric O. Freed
Publikováno v:
mBio, Vol 12, Iss 1 (2021)
Although combination antiretroviral (ARV) therapy is highly effective in controlling the progression of HIV disease, drug resistance can be a major obstacle. Recent findings suggest that resistance can develop without ARV target gene mutations.
Externí odkaz:
https://doaj.org/article/a4bd72fa01324caca28f6cbce9932f14
Publikováno v:
Viruses, Vol 14, Iss 1, p 104 (2022)
COVID-19 vaccines were first administered on 15 December 2020, marking an important transition point for the spread of SARS-CoV-2 in the United States (U.S.). Prior to this point in time, the virus spread to an almost completely immunologically naïv
Externí odkaz:
https://doaj.org/article/11d3d26fa43740f5a3e281f7522b0c9c
Publikováno v:
Retrovirology, Vol 15, Iss 1, Pp 1-12 (2018)
Abstract Characterizing HIV genetic diversity and evolution during antiretroviral therapy (ART) provides insights into the mechanisms that maintain the viral reservoir during ART. This review describes common methods used to obtain and analyze intra-
Externí odkaz:
https://doaj.org/article/2c4d1f48ac144c21abbd00d96517f916