Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mary Ellen Dahlgren"'
Autor:
Shrenik K. Shah, Pam S. Dellea, Paul E. Finke, James B. Doherty, Kevan R. Thompson, Karen M. Hand, D. S. Fletcher, Alan L. Maycock, Bonnie M. Ashe, Mary Ellen Dahlgren
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2283-2288
Penicillin amides substituted at C-6 with either an α- or β-trifluoroacetamido or an α-alkoxy functionality are reported as human leukocyte elastase (HLE) inhibitors. The structure activity relations for these derivatives are discussed and compare
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::28429214fb69091dd791b0ba82100a8e
https://doi.org/10.1016/s0960-894x(01)80940-9
https://doi.org/10.1016/s0960-894x(01)80940-9
Publikováno v:
Biotechnology Progress. 9:580-586
We have developed shake-flask screening conditions that are predictive of specific expression of the chimeric toxin, TGFα-PE40, by recombinant Escherichia coli JM109 in stirred bioreactors. When a nutrient-rich stirred bioreactor medium was used in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33d7d634c7034a2a5e7ea755dc1bd385
https://doi.org/10.1021/bp00024a003
https://doi.org/10.1021/bp00024a003
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 3:2277-2282
Penem benzyl esters substituted at the 6-position with small alkyl groups and at the 3-position with a variety of carbon and heteroatom groups were prepared as inhibitors of human leukocyte elastase (HLE). The structure activity relations found for t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7c5e14efba9cd8c6b4e48865287b3079
https://doi.org/10.1016/s0960-894x(01)80939-2
https://doi.org/10.1016/s0960-894x(01)80939-2
Autor:
Thomas J. Blacklock, Laura A. O'Grady, C. P. Jun. Dorn, G. O. Chandler, Raymond A. Firestone, Peter L. Barker, Kevan R. Thompson, Mary Ellen Dahlgren, Alan L. Maycock, Bonnie M. Ashe, Manuel A. Navia, S. K. Shah, W. B. Knight, P. Davies, Judith M. Pisano, Morris Zimmerman, W. K. Hagmann, J. B. Doherty, John W. Butcher, P. E. Finke, H. Weston, T. Halgren
Publikováno v:
ChemInform. 22
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7821159f7592fd1fd3d97f4b9eac6366
https://doi.org/10.1002/chin.199108336
https://doi.org/10.1002/chin.199108336
Publikováno v:
Biotechnology progress. 22(2)
Lipopeptides such as pneumocandin B(0) are often produced by fermentation processes. Many compounds with similar structures (structural analogues), and hence similar physiochemical properties, are coproduced in the fermentation. We employed high perf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::abfeb637f66f582bbfec2155ebd78d7f
https://pubmed.ncbi.nlm.nih.gov/16599574
https://pubmed.ncbi.nlm.nih.gov/16599574
Autor:
A. L. Powell, R. Z. Maigetter, George Hugh A, Wayne K. Herber, S. M. Stirdivant, Bruce Burgess, Randolph Greasham, Mary Ellen Dahlgren
Publikováno v:
Biotechnology and bioengineering. 40(3)
Physiological effects of isopropyl-thiogalactopyranoside (IPTG) induction were examined in Escherichia coli strain JM109 expressing a fusion protein composed of transforming growth factor alpha and a 40-kD portion of Pseudomonas aeruginosa exotoxin A
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ef445a70e2dc29147e3a39fcc3689e2
https://pubmed.ncbi.nlm.nih.gov/18601135
https://pubmed.ncbi.nlm.nih.gov/18601135
Autor:
Jennifer Mao, Thomas E. Nolan, Stephen G. Pacholok, Hollis R. Williams, Daniel S. Fletcher, Mary Ellen Dahlgren, William A. Hanlon, Richard A. Mumford, Linda W. Schaffer, Karen M. Hand, John L. Humes, James B. Doherty, R. J. Bonney, Philip Davies, Dale Frankenfield
Publikováno v:
Annals of the New York Academy of Sciences. 624
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63c4bb3195dd178d50d1fdeea4ce1758
https://pubmed.ncbi.nlm.nih.gov/2064218
https://pubmed.ncbi.nlm.nih.gov/2064218
Autor:
Philip Davies, Bonnie M. Ashe, John W. Butcher, Peter L. Barker, J. B. Doherty, Paul E. Finke, G. O. Chandler, C P Dorn, Mary Ellen Dahlgren, Thomas J. Blacklock
Publikováno v:
Journal of medicinal chemistry. 33(9)
Time-dependent inhibitors of the enzyme human leukocyte elastase have been developed based on the cephem nucleus. A series of cephalosporin tert-butyl esters has been examined, and the activity of these compounds has been found to be very sensitive t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::229b2b1691997125c8b04ceb65397224
https://pubmed.ncbi.nlm.nih.gov/2391691
https://pubmed.ncbi.nlm.nih.gov/2391691
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 630:338-351
Cultured thioglycollate-elicited mouse peritoneal macrophages secrete an enzyme which hydrolyzes [3H]elastin prepared by NaB3H4 reduction of bovine ligamentum nuchae elastin. Over a 24 h culture period, 3.5 . 10(6) thioglycollate-elicited cells secre
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79d849a22340f33805b62d499e5f2c84
https://doi.org/10.1016/0304-4165(80)90282-2
https://doi.org/10.1016/0304-4165(80)90282-2
Publikováno v:
Biochemical Journal. 200:441-444
Resident mouse peritoneal macrophages have three phospholipase activities: a phospholipase A2 active at pH 4.5, a Ca2+-dependent phospholipase A2 active at pH 8.5 and a phosphatidylinositol-specific phospholipase C activity. When macrophages are expo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9eb7f44dd02d060f104b233c95308a42
https://doi.org/10.1042/bj2000441
https://doi.org/10.1042/bj2000441