Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mary Ellen, Pease"'
Autor:
Elizabeth Kimball, Julie Schaub, Sarah Quillen, Casey Keuthan, Mary Ellen Pease, Arina Korneva, Harry Quigley
Publikováno v:
PLoS ONE, Vol 16, Iss 2, p e0244123 (2021)
PurposeTo study aquaporin channel expression in astrocytes of the mouse optic nerve (ON) and the response to IOP elevation in mice lacking aquaporin 4 (AQP4 null).MethodsC57BL/6 (B6) and AQP4 null mice were exposed to bead-induced IOP elevation for 3
Externí odkaz:
https://doaj.org/article/47d801fd0fe44be8b2e89ebd41726a67
Autor:
Salaheddine, Madhoun, Manuela Tosi Comelis, Martins, Arina, Korneva, Thomas V, Johnson, Elizabeth, Kimball, Sarah, Quillen, Mary Ellen, Pease, Malia, Edwards, Harry, Quigley
Publikováno v:
Exp Eye Res
To identify changes in response to experimental intraocular pressure (IOP) elevation associated with the laminin α1 nmf223 mutation in mice. Laminin mutant (LM) mice (Lama1(nmf223)) and C57BL/6J (B6) mice in two age groups each (4-5 months and >1 ye
Autor:
Salaheddine Madhoun, Manuela Tosi Comelis Martins, Arina Korneva, Thomas V. Johnson, Elizabeth Kimball, Sarah Quillen, Mary Ellen Pease, Malia Edwards, Harry Quigley
Publikováno v:
Experimental Eye Research. 226:109341
Autor:
Harry A Quigley, Ian F Pitha, Derek S Welsbie, Cathy Nguyen, Matthew R Steinhart, Thao D Nguyen, Mary Ellen Pease, Ericka N Oglesby, Cynthia A Berlinicke, Katherine L Mitchell, Jessica Kim, Joan J Jefferys, Elizabeth C Kimball
Publikováno v:
PLoS ONE, Vol 10, Iss 10, p e0141137 (2015)
PURPOSE:To determine if oral losartan treatment decreases the retinal ganglion cell (RGC) death caused by experimental intraocular pressure (IOP) elevation in mice. METHODS:We produced IOP increase in CD1 mice and performed unilateral optic nerve cru
Externí odkaz:
https://doaj.org/article/0d0747c61877472a92a3e9b845b4eee6
Autor:
Carolyn, Guan, Mary Ellen, Pease, Sarah, Quillen, Yik Tung Tracy, Ling, Ximin, Li, Elizabeth, Kimball, Thomas V, Johnson, Thao D, Nguyen, Harry A, Quigley
Publikováno v:
Investigative Opthalmology & Visual Science. 63:18
To measure quantitatively changes in lamina cribrosa (LC) cell and connective tissue structure in human glaucoma eyes.We studied 27 glaucoma and 19 age-matched non-glaucoma postmortem eyes. In 25 eyes, LC cross-sections were examined by confocal and
Autor:
Harry A. Quigley, Mary Ellen Pease, Yik Tung Tracy Ling, Elizabeth C. Kimball, Thao D. Nguyen, Joan L. Jefferys
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose To conduct quantitative analysis of astrocytic glial fibrillary acidic protein (GFAP), actin and nuclei distribution in mouse optic nerve (ON) and investigate changes in the measured features after 3 days of ocular hypertension (OHT). Method
Autor:
Sarah Quillen, Mary Ellen Pease, Elizabeth C. Kimball, Arina Korneva, Harry A. Quigley, Julie Schaub
Publikováno v:
PLoS ONE, Vol 15, Iss 8, p e0238104 (2020)
PLoS ONE
PLoS ONE
PurposeTo delineate responses of optic nerve head astrocytes to sustained intraocular pressure (IOP) elevation in mice.MethodsWe elevated IOP for 1 day to 6 weeks by intracameral microbead injection in 4 strains of mice. Astrocyte alterations were st
Autor:
Elizabeth C. Kimball, Mary Ellen Pease, Ericka N. Oglesby, Cathy Nguyen, Julie Schaub, Joan L. Jefferys, Ian Pitha, Harry A. Quigley
Publikováno v:
Experimental Eye Research. 172:78-85
The purpose of this study was to compare younger and older mice after chronic intraocular pressure (IOP) elevation lasting up to 4 days with respect to mitochondrial density, structure, and movement, as well as axonal integrity, in an ex vivo explant
Autor:
Dan Midgett, Elizabeth C. Kimball, Thao D. Nguyen, Mary Ellen Pease, Harry A. Quigley, Cathy Nguyen, Julie Schaub, Joan L. Jefferys
Publikováno v:
Investigative Ophthalmology & Visual Science
Purpose The purpose of this study was to measure the full-field deformation response to IOP change in the peripapillary sclera (PPS) and astrocytic lamina cribrosa (ALC) of young and old mouse eyes ex vivo. Methods Thirty-eight transgenic reporter mi
Autor:
Cathy Nguyen, Ericka N. Oglesby, Matthew R. Steinhart, Ian Pitha, Elizabeth C. Kimball, Harry A. Quigley, Mary Ellen Pease
Publikováno v:
Experimental Eye Research. 160:106-115
We developed an explant model of the mouse eye and optic nerve that facilitates the study of retinal ganglion cell axons and mitochondria in the living optic nerve head (ONH) in an ex vivo environment. Two transgenic mouse strains were used, one expr