Zobrazeno 1 - 10
of 38
pro vyhledávání: '"Mary Elizabeth Pownall"'
Autor:
Gideon L. Hughes, Michael A. Lones, Matthew Bedder, Peter D. Currie, Stephen L. Smith, Mary Elizabeth Pownall
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 10 (2020)
Animal models of human disease provide an in vivo system that can reveal molecular mechanisms by which mutations cause pathology, and, moreover, have the potential to provide a valuable tool for drug development. Here, we have developed a zebrafish m
Externí odkaz:
https://doaj.org/article/a325a435c6074fada412d78e3de69ba3
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4951 (2009)
FGF signaling has multiple roles in regulating processes in animal development, including the specification and patterning of the mesoderm. In addition, FGF signaling supports self renewal of human embryonic stem cells and is required for differentia
Externí odkaz:
https://doaj.org/article/d5db489981464e1ebd996da6b55b98ad
Autor:
Matthew Bedder, Stephen L. Smith, Gideon L. Hughes, Peter D. Currie, Michael A. Lones, Mary Elizabeth Pownall
Publikováno v:
Disease Models & Mechanisms, Vol 13, Iss 10 (2020)
Disease Models & Mechanisms
article-version (VoR) Version of Record
Disease Models & Mechanisms
article-version (VoR) Version of Record
Animal models of human disease provide an in vivo system that can reveal molecular mechanisms by which mutations cause pathology, and, moreover, have the potential to provide a valuable tool for drug development. Here, we have developed a zebrafish m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::824b6dfecdfdf51fb8535f367c3b4b2a
http://dmm.biologists.org/content/13/10/dmm045815
http://dmm.biologists.org/content/13/10/dmm045815
Publikováno v:
Mechanisms of Development. 146:1-9
Myogenic regulatory factors (MRFs) are known to have essential roles in both the establishment and differentiation of the skeletal muscle cell lineage. MyoD is expressed early in the Xenopus mesoderm where it is present and active several hours befor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e19c77d9e5a8958c5ef04202e7119b45
https://doi.org/10.1016/j.mod.2017.05.002
https://doi.org/10.1016/j.mod.2017.05.002
Fibroblast growth factors (FGFs) comprise a family of signalling molecules with essential roles in early embryonic development across animal species. The role of FGFs in mesoderm formation and patterning in Xenopus has been particularly well studied.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f700f5c62cad5693552caea249152bd8
https://eprints.whiterose.ac.uk/158238/1/Elsy_et_al_2020.pdf
https://eprints.whiterose.ac.uk/158238/1/Elsy_et_al_2020.pdf
Gene regulatory networks underpinning skeletal muscle determination and differentiation have been extensively investigated, providing molecular insights into how cell lineages are established during development. These studies have exclusively focused
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ff561f228f8e0c5ba02e2259e53903f0
https://eprints.whiterose.ac.uk/146991/1/Pownall_1_s2.0_S001216061930106X_main.pdf
https://eprints.whiterose.ac.uk/146991/1/Pownall_1_s2.0_S001216061930106X_main.pdf
Autor:
Jane E. Alty, Amy Cording, Richard Maguire, Diana Ivanoiu, Christopher J. H. Elliott, Camille Lyle, Michael A. Lones, Mary Elizabeth Pownall, Jeremy Cosgrove, Matthew Bedder, Stephen L. Smith
Publikováno v:
IET Systems Biology. 9:226-233
This study describes how the application of evolutionary algorithms (EAs) can be used to study motor function in humans with Parkinson’s disease (PD) and in animal models of PD. Human data is obtained using commercially available sensors via a rang
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5b1de822f86bb08f2fff3a57061c70
https://doi.org/10.1049/iet-syb.2015.0030
https://doi.org/10.1049/iet-syb.2015.0030
Autor:
Julia J. Day, Asilatu Shechonge, Kanchon K. Dasmahapatra, Mary Elizabeth Pownall, Gemma Sutton, Lewis J. White
Publikováno v:
Royal Society Open Science
Royal Society Open Science, Vol 7, Iss 10 (2020)
Royal Society Open Science, Vol 7, Iss 10 (2020)
Tetrapods and fish have adapted distinct carbamoyl-phosphate synthase (CPS) enzymes to initiate the ornithine urea cycle during the detoxification of nitrogenous wastes. We report evidence that in the ureotelic subgenus of extremophile fishOreochromi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d22c5de388593a0021b98580ba3bb7
https://doi.org/10.1098/rsos.201200
https://doi.org/10.1098/rsos.201200
Publikováno v:
Developmental Biology. 391(2):207-218
Genetic studies have established that heparan sulphate proteoglycans (HSPGs) are required for signalling by key developmental regulators, including Hedgehog, Wnt/Wg, FGF, and BMP/Dpp. Post-synthetic remodelling of heparan sulphate (HS) by Sulf1 has b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43bf8fb9e45da226c0349a65aefc88d4
Autor:
Pierson Ebrom, Mary Elizabeth Pownall, Jessica Planamento, Neil Krulewitz, Emma M. Wade, Jason R. Meyers
Publikováno v:
Developmental Biology. 378(2):107-121
Heparan sulfate proteoglycans (HSPGs) are glycosylated extracellular or membrane-associated proteins. Their unbranched heparan sulfate (HS) disaccharide chains interact with many growth factors and receptors, modifying their activity or diffusion. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77eeefe0b19b425b122fe922555ff42f