Výsledky vyhledávání - "Mary E. Tarantino"

Kinetic Analysis of the Effect of N-terminal Acetylation in Thymine DNA Glycosylase

Publikováno v: Biochemistry

Thymine DNA glycosylase (TDG) is tasked with initiating DNA base excision repair by recognizing and removing T, U, the chemotherapeutic 5-fluorouracil (5-FU) and many other oxidized and halogenated pyrimidine bases. TDG contains a long, unstructured

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ef3bc0610906af7194d64a582e56db98
https://europepmc.org/articles/PMC9117521/

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Nucleosomes and the three glycosylases: High, medium, and low levels of excision by the uracil DNA glycosylase superfamily

Autor: Alexander C. Drohat, Sarah Delaney, Mary E. Tarantino, Blaine J. Dow

Publikováno v: DNA repair. 72

Human cells express the UDG superfamily of glycosylases, which excise uracil (U) from the genome. The three members of this structural superfamily are uracil DNA glycosylase (UNG/UDG), single-strand selective monofunctional uracil DNA glycosylase (SM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c220518c8a5e16f6eabcf1dd026c665
https://pubmed.ncbi.nlm.nih.gov/30268365

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Human Oxoguanine Glycosylase 1 Removes Solution Accessible 8-Oxo-7,8-dihydroguanine Lesions from Globally Substituted Nucleosomes Except in the Dyad Region

Autor: Sarah Delaney, Mary E. Tarantino, Katharina Bilotti

Publikováno v: Biochemistry. 57(9)

Persistent DNA damage is responsible for mutagenesis, aging, and disease. Repair of the prototypic oxidatively damaged guanine lesion 8-oxo-7,8-dihydroguanine (8-oxoG) is initiated by oxoguanine glycosylase (hOGG1 in humans). In this work, we examine

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0290f90717652f2cd664cc87ad17ff75
https://pubmed.ncbi.nlm.nih.gov/29341606

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Rate-determining Step of Flap Endonuclease 1 (FEN1) Reflects a Kinetic Bias against Long Flaps and Trinucleotide Repeat Sequences

Autor: Sarah Delaney, Katharina Bilotti, Mary E. Tarantino, Ji Huang

Publikováno v: Journal of Biological Chemistry. 290:21154-21162

Flap endonuclease 1 (FEN1) is a structure-specific nuclease responsible for removing 5'-flaps formed during Okazaki fragment maturation and long patch base excision repair. In this work, we use rapid quench flow techniques to examine the rates of 5'-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03e5fa88d68ab378e783dc13d58f5fd7
https://doi.org/10.1074/jbc.m115.666438

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