Výsledky vyhledávání - "Mary E. Schulz"

Akademický článek

Blockade of endothelial Mas receptor restores the vasomotor response to phenylephrine in human resistance arterioles pretreated with captopril and exposed to propofol

Autor: Mary E. Schulz, Joseph C. Hockenberry, Boran Katunaric, Paul S. Pagel, Julie K. Freed

Publikováno v: BMC Anesthesiology, Vol 22, Iss 1, Pp 1-6 (2022)

Abstract Background Hypotension that is resistant to phenylephrine is a complication that occurs in anesthetized patients treated with angiotensin converting enzyme (ACE) inhibitors. We tested the hypothesis that Ang 1–7 and the endothelial Mas rec

Externí odkaz: https://doaj.org/article/b61412f3162d48e48ffdf5f5117c8ff6

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Akademický článek

Role of Adiponectin Receptor 1 in Promoting Nitric Oxide-Mediated Flow-Induced Dilation in the Human Microvasculature

Autor: Katie E. Cohen, Boran Katunaric, Mary E. Schulz, Gopika SenthilKumar, Micaela S. Young, James E. Mace, Julie K. Freed

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

Chronic administration of exogenous adiponectin restores nitric oxide (NO) as the mediator of flow-induced dilation (FID) in arterioles collected from patients with coronary artery disease (CAD). Here we hypothesize that this effect as well as NO sig

Externí odkaz: https://doaj.org/article/9067a2811db04420b4fcbd330fe29e94

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Akademický článek

The anti-viral dynamin family member MxB participates in mitochondrial integrity

Autor: Hong Cao, E. W. Krueger, Jing Chen, Kristina Drizyte-Miller, Mary E. Schulz, Mark A. McNiven

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

Mx proteins belong to the dynamin family of large GTPases and are highly induced by interferon in virally infected cells. The authors show that uninfected immune cells and hepatocytes also express MxB protein that associates with mitochondria to alte

Externí odkaz: https://doaj.org/article/f7bc8160d7f84107957d916022d0b4ee

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Akademický článek

Manipulation of the Sphingolipid Rheostat Influences the Mediator of Flow‐Induced Dilation in the Human Microvasculature

Autor: Mary E. Schulz, Boran Katunaric, Joseph C. Hockenberry, David D. Gutterman, Julie K. Freed

Publikováno v: Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 8, Iss 17 (2019)

Background Elevated levels of ceramide, a sphingolipid known to cause a transition from nitric oxide (NO)– to hydrogen peroxide–dependent flow‐induced dilation (FID) in human arterioles, correlate with adverse cardiac events. However, elevation

Externí odkaz: https://doaj.org/article/42ccd2f7aba3410a8d6529bb53450bdc

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17β-Estradiol promotes sex-specific dysfunction in isolated human arterioles

Autor: Gopika SenthilKumar, Boran Katunaric, Henry Bordas-Murphy, Micaela Young, Erin L. Doren, Mary E. Schulz, Michael E. Widlansky, Julie K. Freed

Publikováno v: American Journal of Physiology-Heart and Circulatory Physiology. 324:H330-H337

Despite data showing that estrogen is vasculoprotective in large conduit arteries, hormone therapy (HT) during menopause has not proven to mitigate cardiovascular disease (CVD) risk. Estrogen exposure through prolonged oral contraceptive use and gend

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18663f9c89787eb7e87da48b4462fd5
https://doi.org/10.1152/ajpheart.00708.2022

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S1P (Sphingosine-1-Phosphate)-Induced Vasodilation in Human Resistance Arterioles During Health and Disease

Autor: Boran Katunaric, Gopika SenthilKumar, Mary E. Schulz, Nilto De Oliveira, Julie K. Freed

Publikováno v: Hypertension (Dallas, Tex. : 1979). 79(10)

Background: Preclinical studies suggest that S1P (sphingosine-1-phosphate) influences blood pressure regulation primarily through NO-induced vasodilation. Because microvascular tone significantly contributes to mean arterial pressure, the mechanism o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::22d8b1f5f68e4935aa72b387bd6cb5be
https://pubmed.ncbi.nlm.nih.gov/36070401

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Abstract 470: Sphingosine-1-Phosphate Signaling In The Human Microvascular Endothelium During Health And Disease

Autor: Gopika SenthilKumar, Boran Katunaric, Henry Bordas-Murphy, Mary E Schulz, Julie K Freed

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 42

The loss of nitric oxide (NO)-mediated flow-induced dilation (FID) in the microvasculature, or microvascular endothelial dysfunction, is strongly linked to future cardiovascular events. Our lab has previously shown that chronic inhibition of sphingos

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f382f0a45d9ec3910a99a4719f87fff3
https://doi.org/10.1161/atvb.42.suppl_1.470

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