Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mary E. Mako"'
Publikováno v:
Proceedings of the National Academy of Sciences. 76:2881-2885
Familial hyperproinsulinemia is an autosomal dominant defect that is associated with strikingly elevated levels of serum proinsulin-like material. Our studies show that trypsin converts familial hyperproinsulinemia proinsulin to insulin more slowly t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb8be7e1658f5599370b204a494426b8
https://doi.org/10.1073/pnas.76.6.2881
https://doi.org/10.1073/pnas.76.6.2881
Autor:
Mary E. Mako, Richard L. Phelps, Richard M. Bergenstal, Arthur H. Rubenstein, Norbert Freinkel, Boyd E. Metzger
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 41:1085-1091
To assess the effects of pregnancy on the relationships between plasma insulin and proinsulin, studies were performed during late gestation in women with normal carbohydrate metabolism or diabetes mellitus. Plasma was secured after overnight fast and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::461b32bda715010550ac6e877c9f5546
https://doi.org/10.1210/jcem-41-6-1085
https://doi.org/10.1210/jcem-41-6-1085
Autor:
Arthur H. Rubenstein, James J Markese, Mary E. Mako, B D Given, Howard S. Tager, Russel Poucher, Masashi Kobayashi, O. Kolterman, Jerrold M. Olefsky, D. Baldwin
Publikováno v:
Nature. 281:122-125
Insulin isolated from the pancreas of a diabetic patient with fasting hyperinsulinaemia showed decreased activity in binding to cell membrane insulin receptors and in stimulating cellular 2-deoxyglucose transport and glucose oxidation. Chemical studi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::511e391f2c2635f8fdde03737923a23a
https://doi.org/10.1038/281122a0
https://doi.org/10.1038/281122a0
Autor:
Masashi Kobayashi, Howard S. Tager, B D Given, Mary E. Mako, Arthur H. Rubenstein, Russel Poucher, Orville G. Kolterman, James J Markese, David S. Baldwin, Jerrold M. Olefsky
Publikováno v:
New England Journal of Medicine. 302:129-135
A 51-year-old, nonobese man with diabetes mellitus had marked hyperinsulinemia (70 to 120 muU per milliliter; 502 to 860 pmol per liter) and fasting hyperglycemia (140 to 170 mg per 100 ml; 7.8 to 9.4 mmol per liter). Plasma proinsulin, glucagon, gro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::800ab671e9b0e16d6413488f85f35d23
https://doi.org/10.1056/nejm198001173020301
https://doi.org/10.1056/nejm198001173020301
Publikováno v:
Diabetes. 27:192-196
The renal handling of proinuslin, insulin, and C-peptide was studied in the isolated perfused rat kidney. At perfusate peptide concentrations below 12 ng./ml. (control value), the organ clearance of proinsulin (637 ± 74 μl. per minute) was signific
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eaaba7ded8944cd1a23ee4c952fc3fd9
https://doi.org/10.2337/diab.27.1.s192
https://doi.org/10.2337/diab.27.1.s192
Autor:
Petra M. Blix, John A. Scarlett, Jose Goldman, Jerrold M. Olefsky, Jonathan B. Jaspan, Arthur H. Rubenstein, Howard S. Tager, David L. Horwitz, Melvin R. Stjernholm, Mary E. Mako
Publikováno v:
New England Journal of Medicine. 297:1029-1032
In seven patients with factitious hypoglycemia due to the surreptitious injection of insulin, we made the diagnosis by measurements of plasma insulin and C-peptide immunoreactivity (in seven patients), facilitated by the finding of circulating insuli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099d8fb87c0a03463d2b4c6c10ba23ac
https://doi.org/10.1056/nejm197711102971903
https://doi.org/10.1056/nejm197711102971903
Autor:
Arthur H. Rubenstein, Hideshi Kuzuya, Jonathan B. Jaspan, David L. Horwitz, Mary E. Mako, Petra M. Blix
Publikováno v:
The Journal of Clinical Endocrinology & Metabolism. 45:441-446
Serum insulin, proinsulin and C-peptidewere measured in six patients with chronicrenal failure and 12 controls in the fasting stateand following oral glucose and iv arginine. Fastinglevels of insulin (0.13 ± 0.05 nM vs. 0.05 ± 0.01 nM),proinsulin (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2d316b7e96e127c3c90a3e3cb972a0d
https://doi.org/10.1210/jcem-45-3-441
https://doi.org/10.1210/jcem-45-3-441
Autor:
James A. Horner, Masashi Kobayashi, Fiser Rh, B D Given, Arthur H. Rubenstein, Joycelyn M. Elders, Raymond L. Hintz, Jerrold M. Olefsky, Heinrich K. Schedwie, Mary E. Mako
Publikováno v:
Proceedings of the National Academy of Sciences. 75:3469-3473
We have studied a 2-year-old girl with acanthosis nigricans, glucose intolerance, marked hyperinsulinemia, and somatic features characteristic of the leprechaunism syndrome. Circulating plasma insulin levels were increased up to 50-fold and the patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070427d23870a2f0a4422008d9e2deb8
https://doi.org/10.1073/pnas.75.7.3469
https://doi.org/10.1073/pnas.75.7.3469
Publikováno v:
Journal of Clinical Investigation. 55:1278-1283
Concentrations of insulin, proinsulin, and C-peptide were measured in portal and peripheral venous blood in six nondiabetic, nonobese subjects. Portal vein samples were obtained by umbilical vein catheterization. Three subjects were studied with intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7c5ce3eeafd1edf7e1c4f50dcd8647c
https://doi.org/10.1172/jci108047
https://doi.org/10.1172/jci108047
Publikováno v:
Diabetes. 20:397-403
The early phase of the insulin secretory response to glucose may not be derived from the total pool of stored insulin, but possibly from a specific and relatively small fraction in a state or locus necessary for its immediate release. In an attempt t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e649f8fbb8900a755b7fcd983473c3c
https://doi.org/10.2337/diab.20.6.397
https://doi.org/10.2337/diab.20.6.397