Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Mary E. Lancaster"'
Autor:
R M Lightfoot, B A Gaskill, Scott S. Sundseth, H R Brown, James E. Weiel, James M. Lenhard, Mary E. Lancaster, Mark A. Paulik, J G Binz
Publikováno v:
Diabetologia. 42:545-554
Aims/hypothesis. Although retinoid X receptor (RXR) and peroxisome proliferator activated receptor-γ (PPARγ) agonists have antidiabetic effects in hyperinsulinaemic animals, little information exists on their effects after pancreatic beta-cell fail
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ebd6ca6b72c1447d3586417a711c711
https://doi.org/10.1007/s001250051193
https://doi.org/10.1007/s001250051193
Autor:
James E. Weiel, Walter S. Dallas, Emily A. Hull-Ryde, Mary E. Lancaster, James M. Lenhard, Richard G. Buckholz, Mark A. Paulik
Publikováno v:
Pharmaceutical Research. 15:944-949
Purpose. Although the effects of thermogenic agents in cell culture can be measured by direct microcalorimetry, only a few samples can be analyzed over several hours. In this report, we describe a robust non-invasive technique to measure real-time th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::71e9e8f0dea5aa3b898b1b3e04424162
https://doi.org/10.1023/a:1011993019385
https://doi.org/10.1023/a:1011993019385
Autor:
Robert J. Mertz, Nathaniel T. Blair, W. Ronald Shehee, Sam M. Witherspoon, Michael W. Roe, Jennings F. Worley, Andrey V. Kuznetsov, M S McIntyre, Anshu A. Mittal, Mary E. Lancaster, Sarmila DasGupta, Iain D. Dukes, Louis H. Philipson
Publikováno v:
Journal of Biological Chemistry. 271:32241-32246
Voltage-dependent delayed rectifier K+ channels regulate aspects of both stimulus-secretion and excitation-contraction coupling, but assigning specific roles to these channels has proved problematic. Using transgenically derived insulinoma cells (βT
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d448b89c5d5461486b5e3a12eab4fa7e
https://doi.org/10.1074/jbc.271.50.32241
https://doi.org/10.1074/jbc.271.50.32241
Autor:
Robert J. Mertz, Mary E. Lancaster, C.J. Frangakis, B. Spencer, A. Kuznetsov, Louis H. Philipson, J.F. Worley rd, M.W. Roe, Iain D. Dukes
Publikováno v:
Journal of Biological Chemistry. 269:18279-18282
Non-insulin-dependent diabetes mellitus (NIDDM) is a metabolic disease associated with abnormal insulin secretion, the underlying mechanisms of which are unknown. Glucose-dependent signal transduction pathways were investigated in pancreatic islets d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4b3e89e48e6b26d1b39f0b88f25bc6ba
https://doi.org/10.1016/s0021-9258(17)32299-8
https://doi.org/10.1016/s0021-9258(17)32299-8
Publikováno v:
American Journal of Physiology-Endocrinology and Metabolism. 266:E852-E862
Stimulation of pancreatic islets of Langerhans with glucose results in changes in intracellular Ca2+ concentration ([Ca2+]i). With the use of mouse islets loaded with fura 2, the earliest glucose-induced alteration of [Ca2+]i was a pronounced decline
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1075f4e4b68990158e2828f7d5ed79a5
https://doi.org/10.1152/ajpendo.1994.266.6.e852
https://doi.org/10.1152/ajpendo.1994.266.6.e852
Publikováno v:
Journal of Biological Chemistry. 268:9953-9956
Glucose-activated beta-cell insulin secretion depends upon elevation of intracellular calcium concentration, [Ca2+]i, which is thought to arise from Ca2+ influx through voltage-dependent calcium channels. Using fura-2-loaded mouse islets, we demonstr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb968a4253ca24a6f58ac9f0e386ace3
https://doi.org/10.1016/s0021-9258(18)82156-1
https://doi.org/10.1016/s0021-9258(18)82156-1
Autor:
David N. Deaton, Kim K. Adkison, Tula Milliken, Kelly Horne Donaldson, Walter L Faison, Robert Hart, David E. Uehling, Neal F. Cariello, Kathleen K. Brown, Mark A. Paulik, Mary E. Lancaster, Esther Y. Chao, Bryan W. Sherman, Conrad Cowan, Jasmine Lin, Elizabeth E. Sugg, Barry G. Shearer
Publikováno v:
Journal of medicinal chemistry. 49(9)
The synthesis of a series of phenethanolamine aniline agonists that contain an aniline ring on the right-hand side of the molecule substituted at the meta position with a benzoic acid or a pyridyl carboxylate is described. Several of the analogues (e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e23efecdde36afb7f8fbfc1945a62e8b
https://pubmed.ncbi.nlm.nih.gov/16640337
https://pubmed.ncbi.nlm.nih.gov/16640337
Autor:
David N. Deaton, Mark A. Paulik, Frank Lee, Kim K. Adkison, Elizabeth E. Sugg, Robert Hart, Clifton E. Hyman, Bryan W. Sherman, Timothy A. True, B.E. Reitter, David Barrett, Conrad Cowan, Mary E. Lancaster, Robert G. Hughes, Kelly Horne Donaldson, David E. Uehling
Publikováno v:
Journal of medicinal chemistry. 45(3)
Starting from phenethanolamine aniline leads 3a and 3b, we have identified a series of functionally potent and selective beta(3) adrenergic receptor (AR) agonists containing acylsulfonamide, sulfonylsulfonamide, or sulfonylurea groups within the anil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fd2c81aa3f421786049ce5ef971b53e
https://pubmed.ncbi.nlm.nih.gov/11806709
https://pubmed.ncbi.nlm.nih.gov/11806709