Zobrazeno 1 - 10
of 125
pro vyhledávání: '"Mary E. Hatten"'
Autor:
Clara Penas, Marie E. Maloof, Vasileios Stathias, Jun Long, Sze Kiat Tan, Jose Mier, Yin Fang, Camilo Valdes, Jezabel Rodriguez-Blanco, Cheng-Ming Chiang, David J. Robbins, Daniel J. Liebl, Jae K. Lee, Mary E. Hatten, Jennifer Clarke, Nagi G. Ayad
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The mechanisms controlling irreversible cell cycle exit in cerebellar granule progenitors (GCPs) have not been fully elucidated. Here, the authors performed RNA-sequencing of GCPs exiting the cell cycle to identify downregulation of Brd4 activity as
Externí odkaz:
https://doaj.org/article/5d102d486ad049ca91e993219a553e49
Autor:
Clara Penas, Eve-Ellen Govek, Yin Fang, Vimal Ramachandran, Mark Daniel, Weiping Wang, Marie E. Maloof, Ronald J. Rahaim, Mathieu Bibian, Daisuke Kawauchi, David Finkelstein, Jeng-Liang Han, Jun Long, Bin Li, David J. Robbins, Marcos Malumbres, Martine F. Roussel, William R. Roush, Mary E. Hatten, Nagi G. Ayad
Publikováno v:
Cell Reports, Vol 11, Iss 2, Pp 249-260 (2015)
Although casein kinase 1δ (CK1δ) is at the center of multiple signaling pathways, its role in the expansion of CNS progenitor cells is unknown. Using mouse cerebellar granule cell progenitors (GCPs) as a model for brain neurogenesis, we demonstrate
Externí odkaz:
https://doaj.org/article/2151b5d008f24920a38f942f1ddc596a
Autor:
Estelle Rousselet, Jadwiga Marcinkiewicz, Jasna Kriz, Ann Zhou, Mary E. Hatten, Annik Prat, Nabil G. Seidah
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 7, Pp 1383-1391 (2011)
Proprotein convertase subtilisin/kexin type 9 (PCSK9) plays a major role in cholesterol homeostasis through enhanced degradation of the LDL receptor (LDLR) in liver. As novel inhibitors/silencers of PCSK9 are now being tested in clinical trials to tr
Externí odkaz:
https://doaj.org/article/bb7124fdb4a340b29439518dc0881cd0
Publikováno v:
eLife, Vol 10 (2021)
Brain development is regulated by conserved transcriptional programs across species, but little is known about the divergent mechanisms that create species-specific characteristics. Among brain regions, human cerebellar histogenesis differs in comple
Externí odkaz:
https://doaj.org/article/3c9fdce4959141d987bb13cae8f26140
SummaryDeveloping neurons undergo a progression of morphological and gene expression changes as they transition from neuronal progenitors to mature, multipolar neurons. Here we use RNA-seq and H3K4me3 and H3K27me3 ChIP-seq to analyze how chromatin mo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::84c22ddb3a60130662e593daebd355a3
https://doi.org/10.1101/2023.02.02.526881
https://doi.org/10.1101/2023.02.02.526881
Autor:
Saša Jereb, Hun-Way Hwang, Eric Van Otterloo, Eve-Ellen Govek, John J Fak, Yuan Yuan, Mary E Hatten, Robert B Darnell
Publikováno v:
eLife, Vol 7 (2018)
Alternative polyadenylation (APA) regulates mRNA translation, stability, and protein localization. However, it is unclear to what extent APA regulates these processes uniquely in specific cell types. Using a new technique, cTag-PAPERCLIP, we discover
Externí odkaz:
https://doaj.org/article/0eab42023df64bc289ab7e10fb10d84f
Autor:
Jose Rodriguez, Kai Liu, Hermann Steller, Avi Levin, Adi Minis, Mary E. Hatten, Eve-Ellen Govek
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance The conserved proteasome-binding protein PI31 serves as an adapter to couple proteasomes with cellular motors to mediate their transport to distal tips of neurons where protein breakdown occurs. We generated global and conditional PI31 k
Publikováno v:
eLife
eLife, Vol 10 (2021)
eLife, Vol 10 (2021)
SummaryBrain development is regulated by conserved transcriptional programs across species, but little is known about divergent mechanisms that create species-specific characteristics. Among brain regions, the cerebellum is now recognized to contribu