Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Mary E. Deadman"'
Autor:
Fabian Klein, Clara Veiga-Villauriz, Anastasiya Börsch, Stefano Maio, Sam Palmer, Fatima Dhalla, Adam E. Handel, Saulius Zuklys, Irene Calvo-Asensio, Lucas Musette, Mary E. Deadman, Andrea J. White, Beth Lucas, Graham Anderson, Georg A. Holländer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The network of thymic stromal cells provides essential niches with unique molecular cues controlling T cell development and selection. Recent single-cell RNA sequencing studies have uncovered previously unappreciated transcriptional heteroge
Externí odkaz:
https://doaj.org/article/58106d4dcccf4fdebf3a90d5d836fcdb
Autor:
Bergithe E. Oftedal, Stefano Maio, Adam E. Handel, Madeleine P. J. White, Duncan Howie, Simon Davis, Nicolas Prevot, Ioanna A. Rota, Mary E. Deadman, Benedikt M. Kessler, Roman Fischer, Nikolaus S. Trede, Erdinc Sezgin, Rick M. Maizels, Georg A. Holländer
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Oftedal et al. generate mice lacking the chaperonin subunit CCT8 in T cells. They find that loss of CCT8 leads to reduced formation of nuclear actin filaments, changes in proteostasis, defective Th2 cell polarization and T cell metabolism and a faile
Externí odkaz:
https://doaj.org/article/f3b7f22ef77541f089085a26cdea4934
Autor:
Manish Sadarangani, J. Claire Hoe, Martin J. Callaghan, Claire Jones, Hannah Chan, Katherine Makepeace, Hélène Daniels-Treffandier, Mary E. Deadman, Christopher Bayliss, Ian Feavers, Peter van der Ley, Andrew J. Pollard
Publikováno v:
PLoS ONE, Vol 8, Iss 10 (2013)
Externí odkaz:
https://doaj.org/article/40a3ee41a3d94954b8df946c2a8b21f5
Autor:
Jeanette Baran-Gale, Michael D Morgan, Stefano Maio, Fatima Dhalla, Irene Calvo-Asensio, Mary E Deadman, Adam E Handel, Ashley Maynard, Steven Chen, Foad Green, Rene V Sit, Norma F Neff, Spyros Darmanis, Weilun Tan, Andy P May, John C Marioni, Chris P Ponting, Georg A Holländer
Publikováno v:
eLife, Vol 9 (2020)
Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol
Externí odkaz:
https://doaj.org/article/0801b66fbced40e4a16cb9a6776b1379
Autor:
Adam E. Handel, Stanley Cheuk, Fatima Dhalla, Stefano Maio, Tania Hübscher, Ioanna Rota, Mary E. Deadman, Olov Ekwall, Matthias Lütolf, Kenneth Weinberg, Georg Holländer
Publikováno v:
Science Advances, 8 (19)
The thymic stroma is composed of epithelial and nonepithelial cells providing separate microenvironments controlling homing, differentiation, and selection of hematopoietic precursor cells to functional T cells. Here, we explore at single-cell resolu
Autor:
Carme Camps, Saulius Zuklys, Tudor A. Fulga, Kieran D. James, N Prevot, B C Lagerholm, C Hanson, Andrea J. White, Adam E. Handel, E Sezgin, Jenny C. Taylor, Gkazi As, F Klein, Eleni Adamopoulou, Yale S. Michaels, Graham Anderson, Helene Dreau, E G Davies, Georg A. Holländer, Alistair T. Pagnamenta, Opher Gileadi, Ioanna A. Rota, Philip D. Charles, Fatima Dhalla, Roman Fischer, Mary E. Deadman, J.A. Newman, Stefano Maio, Stanley Cheuk, W Quasim, Philip Hublitz
Publikováno v:
Science Advances, 7 (49)
Science Advances
Science Advances
The transcription factor FOXN1 is a master regulator of thymic epithelial cell (TEC) development and function. Here, we demonstrate that FOXN1 expression is differentially regulated during organogenesis and participates in multimolecular nuclear cond
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::881ae1218ef03ae16d4a1f1913f63a64
https://hdl.handle.net/20.500.11850/520258
https://hdl.handle.net/20.500.11850/520258
Autor:
Ioanna A. Rota, Olov Ekwall, Stanley Cheuk, Matthias P. Lutolf, Mary E. Deadman, Fatima Dhalla, Georg A. Holländer, Kenneth I. Weinberg, Adam E. Handel, Tania Hübscher, Stefano Maio
The thymic stroma is composed of epithelial and non-epithelial cells that collectively provide separate microenvironments controlling the homing of blood-born precursors to the tissue, and their subsequent differentiation to functionally mature and c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5f657b58d910ee8dfbc85f0db359faef
https://doi.org/10.1101/2021.11.08.467624
https://doi.org/10.1101/2021.11.08.467624
Autor:
White Mpj., Mary E. Deadman, Duncan Howie, Ioanna A. Rota, Roman Fischer, Nikolaus S. Trede, Adam E. Handel, Georg A. Holländer, Bergithe E Oftedal, Benedikt M. Kessler, N Prevot, Rick M. Maizels, Simon J. Davis, Erdinc Sezgin, Stefano Maio
Publikováno v:
Communications Biology, Vol 4, Iss 1, Pp 1-14 (2021)
Communications Biology
Communications Biology, 4 (1)
Communications Biology
Communications Biology, 4 (1)
T cells rely for their development and function on the correct folding and turnover of proteins generated in response to a broad range of molecular cues. In the absence of the eukaryotic type II chaperonin complex, CCT, T cell activation induced chan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1fdf286cea5a98cf4e6d87b3b8500a56
https://ora.ox.ac.uk/objects/uuid:98b26ca7-9dd0-4cff-b27c-f76d0324a584
https://ora.ox.ac.uk/objects/uuid:98b26ca7-9dd0-4cff-b27c-f76d0324a584
Autor:
Norma F. Neff, Jeanette Baran-Gale, Ashley Maynard, Fatima Dhalla, Rene Sit, Chris P. Ponting, AP May, Weilun Tan, Steven Chen, Foad Green, Georg A. Holländer, Morgan, Adam E. Handel, Stefano Maio, John C. Marioni, Spyros Darmanis, Mary E. Deadman, Irene Calvo-Asensio
Publikováno v:
eLife
Baran-Gale, J, Morgan, M D, Maio, S, Dhalla, F, Calvo-Asensio, I, Deadman, M E, Handel, A E, Maynard, A, Chen, S, Green, F, Sit, R V, Neff, N F, Darmanis, S, Tan, W, May, A P, Marioni, J C, Ponting, C P & Holländer, G A 2020, ' Ageing compromises mouse thymus function and remodels epithelial cell differentiation ', eLIFE, vol. 9, no. 8, e56221 . https://doi.org/10.7554/eLife.56221
eLife, Vol 9 (2020)
eLife, 9
Baran-Gale, J, Morgan, M D, Maio, S, Dhalla, F, Calvo-Asensio, I, Deadman, M E, Handel, A E, Maynard, A, Chen, S, Green, F, Sit, R V, Neff, N F, Darmanis, S, Tan, W, May, A P, Marioni, J C, Ponting, C P & Holländer, G A 2020, ' Ageing compromises mouse thymus function and remodels epithelial cell differentiation ', eLIFE, vol. 9, no. 8, e56221 . https://doi.org/10.7554/eLife.56221
eLife, Vol 9 (2020)
eLife, 9
Ageing is characterised by cellular senescence, leading to imbalanced tissue maintenance, cell death and compromised organ function. This is first observed in the thymus, the primary lymphoid organ that generates and selects T cells. However, the mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f8fc8a5ee53b84a3b59dd1f67e8e1170
Autor:
Mary E. Deadman, Stefano Maio, Irene Calvo-Asensio, Michael D Morgan, Rene Sit, Ashley Maynard, Jeanette Baran-Gale, Georg A. Holländer, Foad Green, Chris P. Ponting, Andy P May, Spyros Darmanis, Fatima Dhalla, Adam E. Handel, John C. Marioni, Norma Neff, Steven Chen, Weilun Tan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::236b8e956ec9ca76520abca1824add7b
https://doi.org/10.7554/elife.56221.sa2
https://doi.org/10.7554/elife.56221.sa2