Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Mary E. Abood"'
Autor:
Luciana M. Leo, Mary E. Abood
Publikováno v:
Molecules, Vol 26, Iss 17, p 5413 (2021)
The CB1 cannabinoid receptor is a G-protein coupled receptor highly expressed throughout the central nervous system that is a promising target for the treatment of various disorders, including anxiety, pain, and neurodegeneration. Despite the wide th
Externí odkaz:
https://doaj.org/article/9cf92677c5a5477ba3340f4544c8e067
Autor:
Eugen Brailoiu, Sumita Chakraborty, G. Cristina Brailoiu, Pingwei Zhao, Jeffrey L. Barr, Marc A. Ilies, Ellen M. Unterwald, Mary E. Abood, Colin W. Taylor
Publikováno v:
Cell Reports, Vol 26, Iss 2, Pp 330-337.e4 (2019)
Summary: Sigma-1 receptors (Sig-1Rs) are integral ER membrane proteins. They bind diverse ligands, including psychoactive drugs, and regulate many signaling proteins, including the inositol 1,4,5-trisphosphate receptors (IP3Rs) that release Ca2+ from
Externí odkaz:
https://doaj.org/article/bba4f71ea52a4806843616fb0bce4be7
Autor:
Paula Morales, Laura Figuerola-Asencio, Dow H. Hurst, Pingwei Zhao, Mary E. Abood, Patricia H. Reggio, Nadine Jagerovic
Publikováno v:
Proceedings, Vol 22, Iss 1, p 92 (2019)
Docking studies of identified GPR55 ligands using a GPR55 inactive state model allow rationalizing key structural features involved in ligand–receptor binding. On this molecular basis, we have designed novel quinolone sulfonamide derivatives with o
Externí odkaz:
https://doaj.org/article/2630e8776f5d4776bbd5423c44a9f3b6
Autor:
Douglas E. Brenneman, William A. Kinney, Mark E. McDonnell, Pingei Zhao, Mary E. Abood, Sara Jane Ward
Publikováno v:
Journal of Molecular Neuroscience. 72:1859-1874
KLS-13019, a novel devised cannabinoid-like compound, was explored for anti-inflammatory actions in dorsal root ganglion cultures relevant to chemotherapy- induced peripheral neuropathy (CIPN). Time course studies with 3 mM paclitaxel indicated >1.9-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95524fae9db572129071a1daa91b6c65
https://doi.org/10.1007/s12031-022-02038-2
https://doi.org/10.1007/s12031-022-02038-2
Autor:
Laura Figuerola-Asencio, Paula Morales, Pingwei Zhao, Dow P. Hurst, Sommayah S. Sayed, Katsuya L. Colón, María Gómez-Cañas, Javier Fernández-Ruiz, Mitchell P. Croatt, Patricia H. Reggio, Mary E. Abood, Nadine Jagerovic
GPR55 is an orphan G-protein coupled receptor involved in various pathophysiological conditions. However, there are only a few noncannabinoid GPR55 ligands reported so far. The lack of potent and selective GPR55 ligands precludes a deep exploration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae463e4b82c805a8a62fc3966e760b0e
http://hdl.handle.net/10261/309060
http://hdl.handle.net/10261/309060
Publikováno v:
JNCI Monographs. 2021:99-106
Plant-based, synthetic, and endogenous cannabinoids have been shown to control a diverse array of biological processes, including regulation of cell fate across cancers. Their promise as broad-based antitumor agents in preclinical models has led to t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::242c59d9c8f9bf3ff43b6a18dc1d7acf
https://doi.org/10.1093/jncimonographs/lgab008
https://doi.org/10.1093/jncimonographs/lgab008
Publikováno v:
Concussion, Vol 2, Iss 4 (2017)
Post-traumatic headache is the most common symptom of postconcussion syndrome and becomes a chronic neurological disorder in a substantial proportion of patients. This review provides a brief overv...
Externí odkaz:
https://doaj.org/article/7213e6426d6d4d4dbf933fb601fdb596
Autor:
Luciana M. Leo, Rufaida Al-Zoubi, Dow P. Hurst, Anna P. Stephan, Pingwei Zhao, Douglas G. Tilley, Elke Miess, Stefan Schulz, Mary E. Abood, Patricia H. Reggio
Publikováno v:
Cannabis and cannabinoid research.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::801b5c55b14222086b07ec6b63a1b618
https://pubmed.ncbi.nlm.nih.gov/35792570
https://pubmed.ncbi.nlm.nih.gov/35792570
Autor:
Dow P. Hurst, Noori Sotudeh, Paula Morales, Eugen Brailoiu, Nadine Jagerovic, Mary E. Abood, Ana Lago-Fernandez, Patricia H. Reggio
Publikováno v:
Journal of Medicinal Chemistry. 63:14216-14227
GPR18 is a G protein-coupled receptor that belongs to the orphan class A family. Even though it shares low sequence homology with the cannabinoid receptors, CB1R and CB2R, a growing body of research suggests its relationship with the endocannabinoid
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9ec701ac7e7e3d69222ad44907e6ddea
https://doi.org/10.1021/acs.jmedchem.0c00926
https://doi.org/10.1021/acs.jmedchem.0c00926
Autor:
Roger G. Pertwee, Jeffrey R. Deschamps, Patricia H. Reggio, Sumanta Garai, Dow P. Hurst, Tallan Black, Ayat Zagzoog, Peter C Schaffer, Stefan Schulz, Melanie E. M. Kelly, Alex Straiker, Mary E. Abood, Robert B. Laprairie, Ganesh A. Thakur, Anna-Maria Szczesniak, Elke Miess, David R. Janero, Luciana M Leo
Publikováno v:
Journal of medicinal chemistry. 64(12)
We apply the magic methyl effect to improve the potency/efficacy of GAT211, the prototypic 2-phenylindole-based cannabinoid type-1 receptor (CB1R) agonist-positive allosteric modulator (ago-PAM). Introducing a methyl group at the α-position of nitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d9cc97f6536941f9e16d11a1fa59b50c
https://pubmed.ncbi.nlm.nih.gov/34019766
https://pubmed.ncbi.nlm.nih.gov/34019766