Zobrazeno 1 - 10
of 66
pro vyhledávání: '"Mary E Rabaglia"'
Autor:
Julia H Kemis, Vanessa Linke, Kelsey L Barrett, Frederick J Boehm, Lindsay L Traeger, Mark P Keller, Mary E Rabaglia, Kathryn L Schueler, Donald S Stapleton, Daniel M Gatti, Gary A Churchill, Daniel Amador-Noguez, Jason D Russell, Brian S Yandell, Karl W Broman, Joshua J Coon, Alan D Attie, Federico E Rey
Publikováno v:
PLoS Genetics, Vol 15, Iss 8, p e1008073 (2019)
The microbial communities that inhabit the distal gut of humans and other mammals exhibit large inter-individual variation. While host genetics is a known factor that influences gut microbiota composition, the mechanisms underlying this variation rem
Externí odkaz:
https://doaj.org/article/6db44a52ce48480e9a173ce78d918b85
Autor:
Mark P Keller, Pradyut K Paul, Mary E Rabaglia, Donnie S Stapleton, Kathryn L Schueler, Aimee Teo Broman, Shuyun Isabella Ye, Ning Leng, Christopher J Brandon, Elias Chaibub Neto, Christopher L Plaisier, Shane P Simonett, Melkam A Kebede, Gloria M Sheynkman, Mark A Klein, Nitin S Baliga, Lloyd M Smith, Karl W Broman, Brian S Yandell, Christina Kendziorski, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 12, Iss 12, p e1006466 (2016)
Human genome-wide association studies (GWAS) have shown that genetic variation at >130 gene loci is associated with type 2 diabetes (T2D). We asked if the expression of the candidate T2D-associated genes within these loci is regulated by a common loc
Externí odkaz:
https://doaj.org/article/a7a38973596a4970afaa372927d78706
Autor:
Zhidong Tu, Mark P Keller, Chunsheng Zhang, Mary E Rabaglia, Danielle M Greenawalt, Xia Yang, I-Ming Wang, Hongyue Dai, Matthew D Bruss, Pek Y Lum, Yun-Ping Zhou, Daniel M Kemp, Christina Kendziorski, Brian S Yandell, Alan D Attie, Eric E Schadt, Jun Zhu
Publikováno v:
PLoS Genetics, Vol 8, Iss 12, p e1003107 (2012)
Complex diseases result from molecular changes induced by multiple genetic factors and the environment. To derive a systems view of how genetic loci interact in the context of tissue-specific molecular networks, we constructed an F2 intercross compri
Externí odkaz:
https://doaj.org/article/0e466adc0d29468ab383a6fed2c47c6b
Autor:
Sushant Bhatnagar, Angie T Oler, Mary E Rabaglia, Donald S Stapleton, Kathryn L Schueler, Nathan A Truchan, Sara L Worzella, Jonathan P Stoehr, Susanne M Clee, Brian S Yandell, Mark P Keller, Debbie C Thurmond, Alan D Attie
Publikováno v:
PLoS Genetics, Vol 7, Iss 10, p e1002323 (2011)
We previously mapped a type 2 diabetes (T2D) locus on chromosome 16 (Chr 16) in an F2 intercross from the BTBR T (+) tf (BTBR) Lep(ob/ob) and C57BL/6 (B6) Lep(ob/ob) mouse strains. Introgression of BTBR Chr 16 into B6 mice resulted in a consomic mous
Externí odkaz:
https://doaj.org/article/f5f6a4e093c04a5b93c5c3211496fac1
Autor:
Qijun Zhang, Vanessa Linke, Katherine A. Overmyer, Lindsay L. Traeger, Kazuyuki Kasahara, Ian J. Miller, Daniel E. Manson, Thomas J. Polaske, Robert L. Kerby, Julia H. Kemis, Edna A. Trujillo, Thiru R. Reddy, Jason D. Russell, Kathryn L. Schueler, Donald S. Stapleton, Mary E. Rabaglia, Marcus Seldin, Daniel M. Gatti, Gregory R. Keele, Duy T. Pham, Joseph P. Gerdt, Eugenio I. Vivas, Aldons J. Lusis, Mark P. Keller, Gary A. Churchill, Helen E. Blackwell, Karl W. Broman, Alan D. Attie, Joshua J. Coon, Federico E. Rey
Publikováno v:
Nature Microbiology. 8:745-745
Autor:
Jason D. Russell, Joshua J. Coon, Paul D. Hutchins, Donald S. Stapleton, Alan D. Attie, Mary E. Rabaglia, Katherine A. Overmyer, Thiru R. Reddy, Gregory R. Keele, Gary A. Churchill, Kathryn L. Schueler, Mark P. Keller, Duy Pham, Vanessa Linke, Karl W. Broman, Daniel M. Gatti, Edna A. Trujillo, Emily M. Cushing, Dain R. Brademan, Ian J. Miller
Publikováno v:
Nature metabolism
Despite the crucial roles of lipids in metabolism, we are still at the early stages of comprehensively annotating lipid species and their genetic basis. Mass spectrometry-based discovery lipidomics offers the potential to globally survey lipids and t
Autor:
Qijun Zhang, Kazuyuki Kasahara, Julia H. Kemis, Helen E. Blackwell, Kathryn L. Schueler, Marcus M. Seldin, Gregory R. Keele, Joshua J. Coon, Gary A. Churchill, Thiru R. Reddy, Jason D. Russell, Thomas J Polaske, Donald S. Stapleton, Vanessa Linke, Mary E. Rabaglia, Alan D. Attie, Mark P. Keller, Daniel E Manson, Ian J. Miller, Edna A. Trujillo, Katherine A. Overmyer, Daniel M. Gatti, Robert L. Kerby, Lindsay L. Traeger, Aldons J. Lusis, Duy Pham, Federico E. Rey, Karl W. Broman, Eugenio I. Vivas, Joseph P. Gerdt
The molecular bases of how host genetic variation impact gut microbiome remain largely unknown. Here, we used a genetically diverse mouse population and systems genetics strategies to identify interactions between molecular phenotypes, including micr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ebb40fd13bce38666e1d9ea64afdbfb
https://doi.org/10.1101/2021.11.29.470403
https://doi.org/10.1101/2021.11.29.470403
Autor:
Christopher H. Emfinger, Eleonora de Klerk, Kathryn L. Schueler, Mary E. Rabaglia, Donnie S. Stapleton, Shane P. Simonett, Kelly A. Mitok, Ziyue Wang, Xinyue Liu, Joao A. Paulo, Qinq Yu, Rebecca L. Cardone, Hannah R. Foster, Sophie L. Lewandowski, José C. Perales, Christina M. Kendziorski, Steven P. Gygi, Richard G. Kibbey, Mark P. Keller, Matthias Hebrok, Matthew J. Merrins, Alan D. Attie
Publikováno v:
JCI insight. 7(10)
Insulin secretion from pancreatic β cells is essential for glucose homeostasis. An insufficient response to the demand for insulin results in diabetes. We previously showed that β cell-specific deletion of Zfp148 (β-Zfp148KO) improves glucose tole
Autor:
Daniel M. Gatti, Rahul Das, Brian S. Yandell, Kelly A. Mitok, Ziyue Wang, Mark P. Keller, Donnie S. Stapleton, Matthew Vincent, Karl W. Broman, Kathryn L. Schueler, Shane P Simonett, Takanao Ishimura, Alan D. Attie, Mary E. Rabaglia, Gary A. Churchill, Christopher H. Emfinger, Tim Beck, Christina Kendziorski
Publikováno v:
J Clin Invest
Genetic susceptibility to type 2 diabetes is primarily due to β cell dysfunction. However, a genetic study to directly interrogate β cell function ex vivo has never been previously performed. We isolated 233,447 islets from 483 Diversity Outbred (D
Autor:
Carlos Perez-Cervantes, Jeffery S. Tessem, Sunyoung Shin, Jason Spaeth, Mary E. Rabaglia, Jeea Choi, Linsin A Smith, Christina Kendziorski, Roland Stein, Alan D. Attie, Shane P Simonett, Kathryn L. Schueler, Mark P. Keller, Jacob A. Herring, Sunduz Keles, Donnie S. Stapleton, Ivan P. Moskowitz, Matthew N. Bernstein, Rhonda Bacher, Chenyang Dong, Daniel R Turkewitz
Publikováno v:
J Clin Invest
The transcription factor NFATC2 induces β cell proliferation in mouse and human islets. However, the genomic targets that mediate these effects have not been identified. We expressed active forms of Nfatc2 and Nfatc1 in human islets. By integrating