Výsledky vyhledávání - "Mary E Natoli"

Akademický článek

Sample-to-answer, extraction-free, real-time RT-LAMP test for SARS-CoV-2 in nasopharyngeal, nasal, and saliva samples: Implications and use for surveillance testing.

Autor: Kathryn A Kundrod, Mary E Natoli, Megan M Chang, Chelsey A Smith, Sai Paul, Dereq Ogoe, Christopher Goh, Akshaya Santhanaraj, Anthony Price, Karen W Eldin, Keyur P Patel, Ellen Baker, Kathleen M Schmeler, Rebecca Richards-Kortum

Publikováno v: PLoS ONE, Vol 17, Iss 2, p e0264130 (2022)

The global COVID-19 pandemic has highlighted the need for rapid, accurate and accessible nucleic acid tests to enable timely identification of infected individuals. We optimized a sample-to-answer nucleic acid test for SARS-CoV-2 that provides result

Externí odkaz: https://doaj.org/article/103431d8ded940dca930d1c41aa32cea

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Allele-Specific Recombinase Polymerase Amplification to Detect Sickle Cell Disease in Low-Resource Settings

Autor: Megan M Chang, Kathryn Kundrod, Jackson Coole, Gladstone Airewele, Venee N. Tubman, Rebecca Richards-Kortum, Mary E. Natoli

Publikováno v: Analytical Chemistry

Sickle cell disease (SCD) is a group of common, life-threatening disorders caused by a point mutation in the β globin gene. Early diagnosis through newborn and early childhood screening, parental education, and preventive treatments are known to red

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aed0aa7479a379f57366063f50af06c6
https://doi.org/10.1021/acs.analchem.0c04191

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Open-Source Miniature Fluorimeter to Monitor Real-Time Isothermal Nucleic Acid Amplification Reactions in Resource-Limited Settings

Autor: Mary E. Natoli, Rebecca Richards-Kortum, Yajur Maker, Kathryn Kundrod, Alex Kortum, Imran Vohra, Jackson Coole, Yubo Tang

Publikováno v: Journal of visualized experiments : JoVE. (168)

Traditional methods to detect and quantify nucleic acids rely on polymerase chain reaction (PCR) and require the use of expensive thermocyclers with integrated fluorescence detection of amplicons. Isothermal nucleic acid amplification technologies el

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39b60135a4dc3a4718ef65a738e81fec
https://pubmed.ncbi.nlm.nih.gov/33616108

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Allele-specific recombinase polymerase amplification for real-time detection of sickle cell anaemia in low-resource settings: evaluation of an isothermal nucleic acid amplification test to detect the βS globin point mutation in paediatric patients

Autor: Venee N. Tubman, Mary E. Natoli, Gladstone Airewele, Jackson Coole, Rebecca Richards-Kortum, Kathryn Kundrod, Megan Chang

Publikováno v: The Lancet Global Health, Vol 9, Iss, Pp S13-(2021)

Background Sickle cell anaemia is a common, life-threatening disorder caused by a point mutation in the β globin gene. The high cost and complexity of conventional diagnostic methods limit the scope and sustainability of newborn screening for sickle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::531c5a3463876fb31d92ff1e41948621
https://doi.org/10.1016/s2214-109x(21)00121-2

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Reverse transcription loop-mediated isothermal amplification (RT-LAMP) for point-of-care detection of SARS-CoV-2: a clinical study to evaluate agreement with RT-qPCR

Autor: Chelsey A. Smith, Keyur P. Patel, Mary E. Natoli, Rebecca Richards-Kortum, Kathleen M. Schmeler, Sai Paul, Megan Chang, Karen Eldin, Kathryn Kundrod, Ellen Baker

Publikováno v: The Lancet. Global Health
The Lancet Global Health, Vol 9, Iss, Pp S3-(2021)

Background: The global COVID-19 pandemic caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has highlighted the need for rapid, accurate, and accessible diagnostics to enable timely treatment and outbreak control. Howeve

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ee4a614ffe787b319a8fd90c88c11680
http://europepmc.org/articles/PMC7952100

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Real-time isothermal nucleic acid amplification detection in resource-limited settings: a description of an open-source miniature fluorimeter

Autor: Mary E. Natoli, Yubo Tang, Rebecca Richards-Kortum, Jackson Coole, Alex Kortum, Kathryn Kundrod, Imran Vohra

Publikováno v: The Lancet. Global Health
The Lancet Global Health, Vol 9, Iss, Pp S6-(2021)

Background The detection and quantification of nucleic acids traditionally relies on PCR, which requires the use of expensive thermocyclers with integrated fluorescence detection of amplicons. While isothermal nucleic acid amplification technologies

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5ea942345318236790d0de7eb2216f2
http://europepmc.org/articles/PMC7952084

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Point-of-care diagnostics to improve maternal and neonatal health in low-resource settings

Autor: Chelsey A. Smith, Rebecca Richards-Kortum, Catherine E. Majors, Kathryn Kundrod, Mary E. Natoli

Publikováno v: Lab on a Chip. 17:3351-3387

Each day, approximately 830 women and 7,400 newborns die from complications during pregnancy and childbirth. Improving maternal and neonatal health will require bringing rapid diagnosis and treatment to the point of care in low-resource settings. How

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64336ca8d4acc08f6220d56a92c1e3b6
https://doi.org/10.1039/c7lc00374a

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Simple and inexpensive quantification of ammonia in whole blood

Autor: Mary E. Natoli, Brian T. Heligman, Gary Cunningham, Marshall L. Summar, Adam M. Behrens, Joseph J. Ayoub, Peter Kofinas, Omar B. Ayyub

Publikováno v: Molecular Genetics and Metabolism. 115:95-100

Quantification of ammonia in whole blood has applications in the diagnosis and management of many hepatic diseases, including cirrhosis and rare urea cycle disorders, amounting to more than 5 million patients in the United States. Current techniques

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a6ba7903403d5c70cf3563045ebac54
https://doi.org/10.1016/j.ymgme.2015.04.004

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Advances in Point-of-Care Diagnostics for Infectious Disease

Autor: Meaghan Bond, Mary E. Natoli, Catherine E. Majors, Richard A. Schwarz, Rebecca Richards-Kortum, Chelsey A. Smith, Brittany A. Rohrman

Publikováno v: Frugal Innovation in Bioengineering for the Detection of Infectious Diseases ISBN: 9783319666457

Recent advances in bioengineering have enabled development of sensitive and specific diagnostic tests that detect and quantify cells, proteins, and nucleic acids. However, the development of diagnostic tests for use in low-resource settings presents

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::09c3d56c18edfa151360fc7d03ea6d3a
https://doi.org/10.1007/978-3-319-66647-1_1

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