Zobrazeno 1 - 10
of 42
pro vyhledávání: '"Mary E Hensler"'
Autor:
Magali Bebien, Mary E Hensler, Suzel Davanture, Li-Chung Hsu, Michael Karin, Jin Mo Park, Lena Alexopoulou, George Y Liu, Victor Nizet, Toby Lawrence
Publikováno v:
PLoS Pathogens, Vol 8, Iss 7, p e1002812 (2012)
Group B Streptococcus (GBS) is a leading cause of invasive bacterial infections in human newborns and immune-compromised adults. The pore-forming toxin (PFT) β hemolysin/cytolysin (βh/c) is a major virulence factor for GBS, which is generally attri
Externí odkaz:
https://doaj.org/article/f131e0299c5a46b099d59ebed32af69a
Publikováno v:
PLoS ONE, Vol 3, Iss 6, p e2446 (2008)
Group B Streptococcus (GBS) is a leading cause of neonatal sepsis where myocardial dysfunction is an important contributor to poor outcome. Here we study the effects of the GBS pore-forming beta-hemolysin/cytolysin (Bh/c) exotoxin on cardiomyocyte vi
Externí odkaz:
https://doaj.org/article/1e326a3a253c41e7b34dd0d6f18cbbe2
Autor:
Leo Lin, Poochit Nonejuie, Jason Munguia, Andrew Hollands, Joshua Olson, Quang Dam, Monika Kumaraswamy, Heriberto Rivera Jr., Ross Corriden, Manfred Rohde, Mary E. Hensler, Michael D. Burkart, Joe Pogliano, George Sakoulas, Victor Nizet
Publikováno v:
EBioMedicine, Vol 2, Iss 7, Pp 690-698 (2015)
Antibiotic resistance poses an increasingly grave threat to the public health. Of pressing concern, rapid spread of carbapenem-resistance among multidrug-resistant (MDR) Gram-negative rods (GNR) is associated with few treatment options and high morta
Externí odkaz:
https://doaj.org/article/e18293e0ce8842e89a217c56927c7952
Autor:
Nina M. Haste, Lauge Farnaes, Mary E. Hensler, Victor Nizet, Varahenage R. Perera, William Fenical
Publikováno v:
Marine Drugs, Vol 9, Iss 4, Pp 680-689 (2011)
There is an urgent need for new antibiotics to treat hospital- and community-associated methicillin-resistant Staphylococcus aureus (MRSA) infections. Previous work has indicated that both terrestrial and marine-derived members of the napyradiomycin
Externí odkaz:
https://doaj.org/article/4b85a820d5f048fbba13afecd1d92cf8
Autor:
Amro Hamdoun, Victor Nizet, Terry Gaasterland, Tristan M. Carland, William H. Gerwick, Joseph P. Campanale, Lena Gerwick, Samantha J. Mascuch, N. Tessa Pierce, Mary E. Hensler, Joshua Olson, Paul D. Boudreau, Hyukjae Choi
Publikováno v:
Journal of natural products, vol 81, iss 3
The cyanobacterial marine natural product honaucin A inhibits mammalian innate inflammation in vitro and in vivo. To decipher its mechanism of action, RNA sequencing was used to evaluate differences in gene expression of cultured macrophages followin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9d36c0e7efd67404383115dee096cefb
https://escholarship.org/uc/item/8gb8z2sf
https://escholarship.org/uc/item/8gb8z2sf
Autor:
George Sakoulas, Poochit Nonejuie, Michael R. Yeaman, Mary E. Hensler, Joshua Olson, Joe Pogliano, Abhay Dhand, Quang Dam, Wdee Thienphrapa, Cheryl Y. M. Okumura, Victor Nizet, Arnold S. Bayer
Publikováno v:
Journal of Molecular Medicine. 92:139-149
Based on in vitro synergy studies, the addition of nafcillin to daptomycin was used to treat refractory methicillin-resistant Staphylococcus aureus (MRSA) bacteremia. Daptomycin is a de facto cationic antimicrobial peptide in vivo, with antistaphyloc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7acf4f9e2a805cfad02e7d5cbd4cb668
https://doi.org/10.1007/s00109-013-1100-7
https://doi.org/10.1007/s00109-013-1100-7
Autor:
Peng Sun, George Sakoulas, Sang-Jip Nam, William Fenical, Dan N. Tran, Wdee Thienphrapa, Mary E. Hensler, Nina M. Haste, Paul R. Jensen, Victor Nizet, Sandra Loesgen
Publikováno v:
The Journal of antibiotics
The rapid rise in antimicrobial resistance in bacteria has generated an increased demand for the development of novel therapies to treat contemporary infections, especially those caused by methicillin-resistant Staphylococcus aureus (MRSA). However,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8d50d3a071b5d029156d122736d3431
http://europepmc.org/articles/PMC3528839
http://europepmc.org/articles/PMC3528839
Autor:
Eric Oldfield, Yonghui Zhang, Mary E. Hensler, Jordan Axelson, Fu Yang Lin, Eunhae Lee, Yang Wang, Douglas A. Mitchell, Ke Wang, Victor Nizet, Rong Cao, Yi Liang Liu, Ran Pang, Katie J. Molohon, Wei Zhu, Kai Li
Publikováno v:
ACS Medicinal Chemistry Letters. 3:402-406
We report the discovery of antibacterial leads, keto- and diketo-acids, targeting two prenyl transferases: undecaprenyl diphosphate synthase (UPPS) and dehydrosqualene synthase (CrtM). The leads were suggested by the observation that keto- and diketo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::926ac177bd98e0dcce3d5374b8dafcbd
https://doi.org/10.1021/ml300038t
https://doi.org/10.1021/ml300038t
Dual Dehydrosqualene/Squalene Synthase Inhibitors: Leads for Innate Immune System-Based Therapeutics
Autor:
Yi Liang Liu, Yonghui Zhang, Ke Wang, Ohn A. Chow, Wei Zhu, Eric Oldfield, Fu Yang Lin, Mary E. Hensler, Victor Nizet, Wdee Thienphrapa, Ran Pang
Publikováno v:
ChemMedChem. 7:561-564
With the rapid rise in bacterial drug-resistance,[1] there is great interest in developing innovative approaches to anti-infective therapy. For example, in the United States, more people die from Staphylococcus aureus infections than die from HIV/AID
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9597ffba14b2963ee0edea107b645156
https://doi.org/10.1002/cmdc.201100589
https://doi.org/10.1002/cmdc.201100589
Autor:
Varahenage R. Perera, Lauge Farnaes, William Fenical, Nina M. Haste, Mary E. Hensler, Victor Nizet
Publikováno v:
Marine Drugs
Marine Drugs, Vol 9, Iss 4, Pp 680-689 (2011)
Marine Drugs; Volume 9; Issue 4; Pages: 680-689
Marine Drugs, Vol 9, Iss 4, Pp 680-689 (2011)
Marine Drugs; Volume 9; Issue 4; Pages: 680-689
There is an urgent need for new antibiotics to treat hospital- and community-associated methicillin-resistant Staphylococcus aureus (MRSA) infections. Previous work has indicated that both terrestrial and marine-derived members of the napyradiomycin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06d1685c02d9b7bb97d0677d445ca23b
http://europepmc.org/articles/PMC3124980
http://europepmc.org/articles/PMC3124980