Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Mary E Gagou"'
Publikováno v:
PLoS Genetics, Vol 5, Iss 1, p e1000324 (2009)
The related PIK-like kinases Ataxia-Telangiectasia Mutated (ATM) and ATM- and Rad3-related (ATR) play major roles in the regulation of cellular responses to DNA damage or replication stress. The pro-apoptotic role of ATM and p53 in response to ionizi
Externí odkaz:
https://doaj.org/article/c2246e09c9954e03898dd502b9a9f0d6
Autor:
Joelle A. Desmarais, Michele J. Hoffmann, Mark Meuth, Peter W. Andrews, Mary E. Gagou, Gregg Bingham
Publikováno v:
Stem Cells. 30:1385-1393
Pluripotent cells of the early embryo, to which embryonic stem cells (ESCs) correspond, give rise to all the somatic cells of the developing fetus. Any defects that occur in their genome or epigenome would have devastating consequences. Genetic and e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c2a355cbf6ce45991579327e9d0db39a
https://doi.org/10.1002/stem.1117
https://doi.org/10.1002/stem.1117
Publikováno v:
Cell Death & Differentiation. 15:889-898
Checkpoint kinase 1 (Chk1) responds to disruption of DNA replication to maintain the integrity of stalled forks, promote homologous recombination-mediated repair of replication fork lesions, and control inappropriate firing of replication origins. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ca05cabc66151bb301d6274d9d21f2c
https://doi.org/10.1038/cdd.2008.4
https://doi.org/10.1038/cdd.2008.4
Publikováno v:
Nucleic Acids Research
The replication protein A (RPA)-ssDNA complex formed at arrested replication forks recruits key proteins to activate the ATR-CHK1 signalling cascade. When CHK1 is inhibited during DNA replication stress, RPA2 is extensively hyperphosphorylated. Here,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0774f44da32c7e23896eae2679a0421
Autor:
Mark Meuth, Mary E. Gagou, Anil Ganesh, Darren Robinson, Angela Cox, Eva Petermann, Geraldine Phear
Publikováno v:
Oncotarget
Scopus-Elsevier
Scopus-Elsevier
// Mary E. Gagou 1 , Anil Ganesh 1 , Geraldine Phear 1 , Darren Robinson 2 , Eva Petermann 3 , Angela Cox 1 , Mark Meuth 1 1 Academic Unit of Molecular Oncology, Department of Oncology, School of Medicine and Biomedical Sciences, University of Sheffi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1e647c86b8451be106310ff58143f42
https://pubmed.ncbi.nlm.nih.gov/25359767
https://pubmed.ncbi.nlm.nih.gov/25359767
Publikováno v:
Cell Death & Disease
The disruption of DNA replication in cells triggers checkpoint responses that slow-down S-phase progression and protect replication fork integrity. These checkpoints are also determinants of cell fate and can help maintain cell viability or trigger c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8460d23dd75549a57de5a4f1b9fb756
https://pubmed.ncbi.nlm.nih.gov/24853431
https://pubmed.ncbi.nlm.nih.gov/24853431
Publikováno v:
Cancer research. 71(14)
Defining the processes that sustain telomere maintenance is critical to our understanding of cancer and longevity. PIF1 is a nonprocessive 5′->3′ human DNA helicase that exhibits broad substrate specificity. In vitro studies have implicated PIF1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7463b9a94e1d50716cfa77854cf540ff
https://pubmed.ncbi.nlm.nih.gov/21616935
https://pubmed.ncbi.nlm.nih.gov/21616935
Publikováno v:
Molecular Biology of the Cell
H2AX phosphorylation at serine 139 (γH2AX) is a sensitive indicator of DNA damage and replication stress. γH2AX levels are strongly enhanced in cells treated with replication inhibitors in the absence Chk1. Our data suggest that this phosphorylatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510e55789058a3bc2ce4cdfafd9955d9
Publikováno v:
Cell
Cell, 2010, 140 (2), pp.235-45. ⟨10.1016/j.cell.2009.12.043⟩
Cell, Elsevier, 2010, 140 (2), pp.235-45. ⟨10.1016/j.cell.2009.12.043⟩
Cell, 2010, 140 (2), pp.235-45. ⟨10.1016/j.cell.2009.12.043⟩
Cell, Elsevier, 2010, 140 (2), pp.235-45. ⟨10.1016/j.cell.2009.12.043⟩
International audience; The mechanisms that safeguard cells against chromosomal instability (CIN) are of great interest, as CIN contributes to tumorigenesis. To gain insight into these mechanisms, we studied the behavior of cells entering mitosis wit
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::171be1236ceda7fd208bec38025e7edc
https://hal.science/hal-00477169
https://hal.science/hal-00477169