Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Mary E, Skinner"'
Autor:
Taolin Yuan, Surinder Kumar, Mary E. Skinner, Ryan Victor-Joseph, Majd Abuaita, Jaap Keijer, Jessica Zhang, Thaddeus J. Kunkel, Yanghan Liu, Elyse M. Petrunak, Thomas L. Saunders, Andrew P. Lieberman, Jeanne A. Stuckey, Nouri Neamati, Fathiya Al-Murshedi, Majid Alfadhel, Johannes N. Spelbrink, Richard Rodenburg, Vincent C.J. de Boer, David B. Lombard
Publikováno v:
iScience, Vol 27, Iss 6, Pp 109991- (2024)
Summary: SIRT5 is a sirtuin deacylase that removes negatively charged lysine modifications, in the mitochondrial matrix and elsewhere in the cell. In benign cells and mouse models, under basal conditions, the phenotypes of SIRT5 deficiency are quite
Externí odkaz:
https://doaj.org/article/1b3e08c25bb044469b8c3e5f02f889fd
Autor:
Stephanie S. Sandoval-Pistorius, Julia E. Gerson, Nyjerus Liggans, Jaimie H. Ryou, Kulin Oak, Xingli Li, Keyshla Y. Negron-Rios, Svetlana Fischer, Henry Barsh, Emily V. Crowley, Mary E. Skinner, Lisa M. Sharkey, Sami J. Barmada, Henry L. Paulson
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-14 (2023)
Abstract The key protein implicated in Parkinson’s disease and other synucleinopathies is α-synuclein, and a post-translationally modified form of the protein, phosphorylated at serine 129 (pS129), is a principal component in Lewy bodies, a pathol
Externí odkaz:
https://doaj.org/article/eaddfd74f32f410b9eea3dbbd5fece4b
Autor:
Jennifer M. Zupancic, Matthew D. Smith, Hanna Trzeciakiewicz, Mary E. Skinner, Sean P. Ferris, Emily K. Makowski, Michael J. Lucas, Nikki McArthur, Ravi S. Kane, Henry L. Paulson, Peter M. Tessier
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Single-domain antibodies, also known as nanobodies, are broadly important for studying the structure and conformational states of several classes of proteins, including membrane proteins, enzymes, and amyloidogenic proteins. Conformational nanobodies
Externí odkaz:
https://doaj.org/article/744b44e777364c28a6fe9024584e8b23
Autor:
Angela H. Guo, Rachael Baliira, Mary E. Skinner, Surinder Kumar, Anthony Andren, Li Zhang, Robert S. Goldsmith, Shaday Michan, Norma J. Davis, Merissa W. Maccani, Sharlene M. Day, David A. Sinclair, Matthew J. Brody, Costas A. Lyssiotis, Adam B. Stein, David B. Lombard
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Heart failure (HF) is the inability of the heart to pump blood sufficiently to meet the metabolic demands of the body. HF with reduced systolic function is characterized by cardiac hypertrophy, ventricular fibrosis and remodeling, and decrea
Externí odkaz:
https://doaj.org/article/f2220b371be640c7a9e5d76ededdbcf9
Autor:
Xinna Li, Mary Hager, Madaline McPherson, Michael Lee, Riha Hagalwadi, Mary E. Skinner, David Lombard, Richard A. Miller
Publikováno v:
GeroScience
Deletion of pregnancy-associated plasma protein-A (PAPP-A), a protease that cleaves some but not all IGF1 binding proteins, postpones late-life diseases and extends lifespan in mice, but the mechanism of this effect is unknown. Here we show that PAPP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::588170a55f1af359dcefb2027b78880c
https://doi.org/10.1007/s11357-022-00692-3
https://doi.org/10.1007/s11357-022-00692-3
Autor:
Stephanie S, Sandoval-Pistorius, Julia E, Gerson, Nyjerus, Liggans, Jaimie H, Ryou, Kulin, Oak, Xingli, Li, Keyshla Y, Negron-Rios, Svetlana, Fischer, Henry, Barsh, Emily V, Crowley, Mary E, Skinner, Lisa M, Sharkey, Sami J, Barmada, Henry L, Paulson
Publikováno v:
Scientific reports. 13(1)
The key protein implicated in Parkinson's disease and other synucleinopathies is α-synuclein, and a post-translationally modified form of the protein, phosphorylated at serine 129 (pS129), is a principal component in Lewy bodies, a pathological hall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::fbd7bd50449312be17b1c9a238f86ee7
https://pubmed.ncbi.nlm.nih.gov/36609661
https://pubmed.ncbi.nlm.nih.gov/36609661
Autor:
Shaday Michan, Adam B. Stein, Hanjia Guo, Surinder Kumar, Mary E. Skinner, Rachael Baliirra, Costas A. Lyssiotis, Sharlene M. Day, David A. Sinclair, David B. Lombard
Publikováno v:
Circulation Research. 129
Heart failure (HF) is defined as an inability of the heart to pump blood sufficiently to meet the metabolic demands of the body. HF with systolic dysfunction is caused by a progressive decline in contractile function and chronic hemodynamic overload,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e4c826f15f8a46e99927ca7d828eb9c
https://doi.org/10.1161/res.129.suppl_1.p511
https://doi.org/10.1161/res.129.suppl_1.p511
Autor:
Mary E. Skinner, Jookta Basu, David B. Lombard, Justin Korfhage, Joel K. Greenson, Richard A. Miller
Publikováno v:
J Gerontol A Biol Sci Med Sci
The diabetes drug canagliflozin extends life span in male mice. Since malignant neoplasms are the major cause of death in most mouse strains, this observation suggests that canagliflozin might exert anti-neoplastic effects in male mice. Here, we trea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::450cdf5361cf380ddec15f5248dd44d7
https://pubmed.ncbi.nlm.nih.gov/34448851
https://pubmed.ncbi.nlm.nih.gov/34448851
Autor:
Mary E. Skinner, Adam B. Stein, David A. Sinclair, Anthony Andren, Maccani Mw, Angela H. Guo, David B. Lombard, Sharleen Day, Long Zhang, Costas A. Lyssiotis, Davis Nj, Michan S, Baliira Rk, Surinder Kumar
Heart failure (HF) is defined as an inability of the heart to pump blood adequately to meet the body’s metabolic demands. HF with reduced systolic function is characterized by cardiac hypertrophy, ventricular fibrosis and remodeling, and decreased
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c312b2dcd2eba6b1efa0d2ea8e3ec38a
https://doi.org/10.1101/2021.06.15.448619
https://doi.org/10.1101/2021.06.15.448619
Autor:
Miguel Rivera, Richard A. Sturm, Sophie Trefely, Peter Sajjakulnukit, Richard A. Scolyer, James S. Wilmott, Keith-Allen Melong, Sowmya Iyer, Costas A. Lyssiotis, Ho-Joon Lee, Min Wang, Andrei L. Osterman, Angela H. Guo, Surinder Kumar, Aleodor A. Andea, Ahmed Mostafa, H. Peter Soyer, Michelle Azar, Lauren Bringman-Rodenbarger, William Giblin, David B. Lombard, Zaneta Nikolovska-Coleska, Li Zhang, Douglas R. Fullen, Ahmed S.A. Mady, David Scott, Sriram Chandrasekaran, Mitchell S. Stark, Nathaniel W. Snyder, Carolina H Chung, Alexander C. Monovich, Marcus Bosenberg, Erika L. Varner, Antonia L. Pritchard, Namrata S Kadambi, Mary E. Skinner, Monique Verhaegen
Publikováno v:
J Clin Invest
Cutaneous melanoma remains the most lethal skin cancer, and ranks third among all malignancies in terms of years of life lost. Despite the advent of immune checkpoint and targeted therapies, only roughly half of patients with advanced melanoma achiev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a13d947c0ca90c8e96d7f70e6c883f86
https://doi.org/10.1172/jci138926
https://doi.org/10.1172/jci138926