Zobrazeno 1 - 10
of 94
pro vyhledávání: '"Mary E, Sehl"'
Autor:
Joshua Zhang, Mary E. Sehl, Roger Shih, Elizabeth Crabb Breen, Fengxue Li, Ake T. Lu, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martinez-Maza, Christina M. Ramirez, Steve Horvath, Beth D. Jamieson
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
Introduction: Highly active antiretroviral therapy (HAART) helps improve some measures of accelerated epigenetic aging in persons living with HIV (PLWH), but its overall impact on the epigenome is not fully understood.Methods: In this study, we analy
Externí odkaz:
https://doaj.org/article/b3905060df8f42c5b15b836f9f6b4669
Autor:
Mary E. Sehl, Elizabeth Crabb Breen, Roger Shih, Fengxue Li, Joshua Zhang, Peter Langfelder, Steve Horvath, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martinez-Maza, Christina M. Ramirez, Beth D. Jamieson
Publikováno v:
Frontiers in Bioinformatics, Vol 4 (2024)
IntroductionPersons living with HIV (PLWH) experience the early onset of age-related illnesses, even in the setting of successful human immunodeficiency virus (HIV) suppression with highly active antiretroviral therapy (HAART). HIV infection is assoc
Externí odkaz:
https://doaj.org/article/b9807aa06bea4118a72dfc77fba1c39e
Autor:
Elizabeth Crabb Breen, Mary E. Sehl, Roger Shih, Peter Langfelder, Ruibin Wang, Steve Horvath, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martínez-Maza, Christina M. Ramirez, Beth D. Jamieson
Publikováno v:
iScience, Vol 26, Iss 8, Pp 107381- (2023)
Externí odkaz:
https://doaj.org/article/9ee0b81a978c4d8d81efed35a74145d8
The impact of reproductive factors on DNA methylation-based telomere length in healthy breast tissue
Publikováno v:
npj Breast Cancer, Vol 8, Iss 1, Pp 1-4 (2022)
Abstract Estrogen promotes breast tissue proliferation and telomerase activation. We investigated the effects of reproductive history on cell cycling and telomere length using a DNA methylation-based estimate of telomere length (DNAmTL) in breast and
Externí odkaz:
https://doaj.org/article/9b7eea92e040439e8c842871f1fd13b8
Publikováno v:
Frontiers in Bioinformatics, Vol 2 (2022)
Accumulation of somatic mutations and genomic instability are hallmarks of both aging and cancer. Epigenetic alterations occur across cell types and tissues with advancing age. DNA methylation-based estimates of biologic age can predict important age
Externí odkaz:
https://doaj.org/article/f67b079c1d6f41e9a679d7f0352e2ec1
Autor:
Mary E. Sehl, Tammy M. Rickabaugh, Roger Shih, Otoniel Martinez-Maza, Steve Horvath, Christina M. Ramirez, Beth D. Jamieson
Publikováno v:
Pathogens and Immunity, Vol 5, Iss 1, Pp 291-311 (2020)
Background: HIV-1 infection is associated with acceleration of age-related methylation patterns in peripheral blood and brain of infected individuals although the relative contributions of HIV-1 infection versus its treatment to the observed accelera
Externí odkaz:
https://doaj.org/article/bca39c858722418d9a71064396d1d39e
Autor:
Mary E. Sehl, Elizabeth Crabb Breen, Roger Shih, Larry Chen, Ruibin Wang, Steve Horvath, Jay H. Bream, Priya Duggal, Jeremy Martinson, Steven M. Wolinsky, Otoniel Martinez-Maza, Christina M. Ramirez, Beth D. Jamieson
Publikováno v:
Frontiers in Genetics, Vol 12 (2022)
Background: Epigenetic aging is accelerated in tissues of persons living with HIV (PLWH) and may underlie the early onset of age-related illnesses. This study examines the rate-of-change in epigenetic age in PLWH following HIV infection but before HA
Externí odkaz:
https://doaj.org/article/3899d6314e1a4354971179465b206a49
Autor:
Alfonso Landeros, Xiang Ji, Kenneth Lange, Timothy C Stutz, Jason Xu, Mary E Sehl, Janet S Sinsheimer
Publikováno v:
PLoS ONE, Vol 16, Iss 5, p e0251242 (2021)
The SARS-CoV-2 pandemic led to closure of nearly all K-12 schools in the United States of America in March 2020. Although reopening K-12 schools for in-person schooling is desirable for many reasons, officials understand that risk reduction strategie
Externí odkaz:
https://doaj.org/article/7ed168186d56484293aa6f2788d26161
Data from Differential Destruction of Stem Cells: Implications for Targeted Cancer Stem Cell Therapy
Cancer stem cells represent a novel therapeutic target. The major challenge in targeting leukemic stem cells (LSC) is finding therapies that largely spare normal hematopoietic stem cells (HSC) while eradicating quiescent LSCs. We present a mathematic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a4748a5ea7ff2f50c938a1a47471b448
https://doi.org/10.1158/0008-5472.c.6500415
https://doi.org/10.1158/0008-5472.c.6500415
Supplementary Table 1 from Differential Destruction of Stem Cells: Implications for Targeted Cancer Stem Cell Therapy
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::02f7d9c2718bb88e0d289a661b3d8735
https://doi.org/10.1158/0008-5472.22383084
https://doi.org/10.1158/0008-5472.22383084