IL-22 alters gut microbiota composition and function to increase aryl hydrocarbon receptor activity in mice and humans

Autor: Jordan S. Mar, Naruhisa Ota, Nick D. Pokorzynski, Yutian Peng, Allan Jaochico, Dewakar Sangaraju, Elizabeth Skippington, Annemarie N. Lekkerkerker, Michael E. Rothenberg, Man-Wah Tan, Tangsheng Yi, Mary E. Keir

Publikováno v: Microbiome, Vol 11, Iss 1, Pp 1-17 (2023)

Abstract Background IL-22 is induced by aryl hydrocarbon receptor (AhR) signaling and plays a critical role in gastrointestinal barrier function through effects on antimicrobial protein production, mucus secretion, and epithelial cell differentiation

Externí odkaz: https://doaj.org/article/07f3567e2214401ab5134a8634835824

Magnetic Resonance Enterography and Histology in Patients With Fibrostenotic Crohn's Disease: A Multicenter Study

Autor: Alexandre Coimbra, Jordi Rimola, Miriam Cuatrecasas, Gert De Hertogh, Gert Van Assche, Ragna Vanslembrouck, Henning Glerup, Agnete Hedemann Nielsen, Rikke Hagemann-Madsen, Yoram Bouhnik, Magaly Zappa, Dominique Cazals-Hatem, Geert D'Haens, Jaap Stoker, Sybren Meijer, Gerhard Rogler, Andreas Boss, Achim Weber, Rui Zhao, Mary E. Keir, Alexis Scherl, Alex de Crespigny, Timothy T. Lu, Julián Panés

Publikováno v: Coimbra, A, Rimola, J, Cuatrecasas, M, De Hertogh, G, Van Assche, G, Vanslembrouck, R, Glerup, H, Nielsen, A H, Hagemann-Madsen, R, Bouhnik, Y, Zappa, M, Cazals-Hatem, D, D'Haens, G, Stoker, J, Meijer, S, Rogler, G, Boss, A, Weber, A, Zhao, R, Keir, M E, Scherl, A, de Crespigny, A, Lu, T T & Panés, J 2022, ' Magnetic Resonance Enterography and Histology in Patients With Fibrostenotic Crohn's Disease : A Multicenter Study ', Clinical and Translational Gastroenterology, vol. 13, no. 7, e00505 . https://doi.org/10.14309/ctg.0000000000000505
Coimbra, A, Rimola, J, Cuatrecasas, M, de Hertogh, G, van Assche, G, Vanslembrouck, R, Glerup, H, Nielsen, A H, Hagemann-Madsen, R, Bouhnik, Y, Zappa, M, Cazals-Hatem, D, D'Haens, G, Stoker, J, Meijer, S, Rogler, G, Boss, A, Weber, A, Zhao, R, Keir, M E, Scherl, A, de Crespigny, A, Lu, T T & Panés, J 2022, ' Magnetic Resonance Enterography and Histology in Patients With Fibrostenotic Crohn's Disease : A Multicenter Study ', CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, vol. 13, no. 7, pp. e00505 . https://doi.org/10.14309/ctg.0000000000000505
Clinical and translational gastroenterology, 13(7). Nature Publishing Group
CLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, 13(7). Nature Publishing Group

INTRODUCTION: Magnetic resonance enterography (MRE) is useful for detecting bowel strictures, whereas a number of imaging biomarkers may reflect severity of fibrosis burden in Crohn's disease (CD). This study aimed to verify the association of MRE me

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a2e7b36f148a23fc90cd9aa8a6d29b0

Identification of an IL-22-Dependent Gene Signature as a Pharmacodynamic Biomarker

Autor: Kevin Huang, Julie Rae, Ann Herman, Mary E. Keir, Jason A. Hackney

Publikováno v: International Journal of Molecular Sciences
Volume 22
Issue 15
International Journal of Molecular Sciences, Vol 22, Iss 8205, p 8205 (2021)

Interleukin-22 (IL-22) plays a role in epithelial barrier function and repair, and may provide benefits in conditions like inflammatory bowel disease. However, limited human data are available to assess the clinical effect of IL-22 administration. Th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096253390c8d3bbbe8564a5c781a34e5

Functional consequences of the macrophage stimulating protein 689C inflammatory bowel disease risk allele.

Autor: Steven E Kauder, Lydia Santell, Elaine Mai, Lilyan Y Wright, Elizabeth Luis, Elsa N N'Diaye, Jeff Lutman, Navneet Ratti, Susan M Sa, Henry R Maun, Eric Stefanich, Lino C Gonzalez, Robert R Graham, Lauri Diehl, William A Faubion, Mary E Keir, Judy Young, Amitabha Chaudhuri, Robert A Lazarus, Jackson G Egen

Publikováno v: PLoS ONE, Vol 8, Iss 12, p e83958 (2013)

Macrophage stimulating protein (MSP) is a serum growth factor that binds to and activates the receptor tyrosine kinase, Recepteur d'Origine Nantais (RON). A non-synonymous coding variant in MSP (689C) has been associated with genetic susceptibility t

Externí odkaz: https://doaj.org/article/6b29382e11a343b58a0d4a762432fc8a

CD28 costimulation regulates genome-wide effects on alternative splicing.

Autor: Manish J Butte, Sun Jung Lee, Jonathan Jesneck, Mary E Keir, W Nicholas Haining, Arlene H Sharpe

Publikováno v: PLoS ONE, Vol 7, Iss 6, p e40032 (2012)

CD28 is the major costimulatory receptor required for activation of naïve T cells, yet CD28 costimulation affects the expression level of surprisingly few genes over those altered by TCR stimulation alone. Alternate splicing of genes adds diversity

Externí odkaz: https://doaj.org/article/bbd92caaa7704dbf954f3ca038b4c4ee