Zobrazeno 1 - 10
of 123
pro vyhledávání: '"Mary E, Gerritsen"'
Autor:
J. Michael Bradshaw, Jens Oliver Funk, David M. Goldstein, Mary E. Gerritsen, Ronald J. Hill, Dane E. Karr, Kwan Leung, Jacob LaStant, Danny Tam, Yan Xing, Timothy D. Owens, Erik Verner, Vernon T. Phan, Ken A. Brameld, Eleni Venetsanakos
Supplementary Table S1. Percentage of enzyme activity following dialysis compared to a non-compound treated control; Supplementary Figure S1. PRN1371 inhibited SNU16 cell proliferation as assessed by BrdU incorporation; Supplementary Figure S2. PRN13
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c5e9e9ff8205d0aa30e44bc8c20f2ed
https://doi.org/10.1158/1535-7163.22503429.v1
https://doi.org/10.1158/1535-7163.22503429.v1
Autor:
Susan K Lyman, Suzanne C Crawley, Ruoyu Gong, Joanne I Adamkewicz, Garth McGrath, Jason Y Chew, Jennifer Choi, Charles R Holst, Leanne H Goon, Scott A Detmer, Jana Vaclavikova, Mary E Gerritsen, Robert A Blake
Publikováno v:
PLoS ONE, Vol 6, Iss 3, p e17692 (2011)
BackgroundMany proteins that are dysregulated or mutated in cancer cells rely on the molecular chaperone HSP90 for their proper folding and activity, which has led to considerable interest in HSP90 as a cancer drug target. The diverse array of HSP90
Externí odkaz:
https://doaj.org/article/f3255661be8a49999d93ff431dca0903
Autor:
Susan K. Lyman, Suzanne C. Crawley, Ruoyu Gong, Joanne I. Adamkewicz, Garth McGrath, Jason Y. Chew, Jennifer Choi, Charles R. Holst, Leanne H. Goon, Scott A. Detmer, Jana Vaclavikova, Mary E. Gerritsen, Robert A. Blake
Publikováno v:
PLoS ONE, Vol 6, Iss 3 (2011)
Externí odkaz:
https://doaj.org/article/2f45722322f6416e9d86caf0046a9f63
Autor:
Mary E. Gerritsen, Dane Karr, Ken A. Brameld, Timothy D. Owens, Vernon T. Phan, Jens Oliver Funk, Eleni Venetsanakos, David G. Loughhead, Tony Ton, Danny Tam, David Michael Goldstein, Erik Verner, Jin Shu, Kwan Leung, Jacob LaStant, J. Michael Bradshaw
Publikováno v:
Journal of Medicinal Chemistry. 60:6516-6527
Aberrant signaling of the FGF/FGFR pathway occurs frequently in cancers and is an oncogenic driver in many solid tumors. Clinical validation of FGFR as a therapeutic target has been demonstrated in bladder, liver, lung, breast, and gastric cancers. O
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87eb832fe7ef7eed3e087cac6857df2b
https://doi.org/10.1021/acs.jmedchem.7b00360
https://doi.org/10.1021/acs.jmedchem.7b00360
Autor:
Erik Verner, Timothy D. Owens, Jens Oliver Funk, Dane Karr, Ken A. Brameld, Danny Tam, J. Michael Bradshaw, Vernon T. Phan, Eleni Venetsanakos, Yan Xing, Kwan Leung, Ronald J. Hill, Mary E. Gerritsen, David Michael Goldstein, Jacob LaStant
Publikováno v:
Molecular cancer therapeutics. 16(12)
An increasing number of cancers are known to harbor mutations, translocations, or amplifications in the fibroblast growth factor receptor (FGFR) family of kinases. The FGFR inhibitors evaluated in clinical trials to date have shown promise at treatin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae9bfe2b30b1509504413bef1d617cb8
https://pubmed.ncbi.nlm.nih.gov/28978721
https://pubmed.ncbi.nlm.nih.gov/28978721
Autor:
Mary E Gerritsen
Publikováno v:
Comprehensive Physiology. :351-383
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f0759e24787cbbb19591ec5d2b918583
https://doi.org/10.1002/cphy.cp020408
https://doi.org/10.1002/cphy.cp020408
Autor:
Timothy D. Owens, Mary E. Gerritsen, Ronald J. Hill, David G Loughhead, J. Michael Bradshaw, Erik Verner, Dane Karr, David Michael Goldstein, Jesse M. McFarland, Vernon T. Phan, Angelina Bisconte, Vaishali Patel, Philip A. Nunn, Jens Oliver Funk, Jin Shu, David Finkle, Danny Tam, Tony Ton, Ken A. Brameld, Ville O. Paavilainen, Xiaoyan Li, Jack Taunton, Sergei Romanov
Publikováno v:
Nature chemical biology, vol 11, iss 7
Nature chemical biology
Nature chemical biology
Drugs with prolonged, on-target residence time often show superior efficacy, yet general strategies for optimizing drug-target residence time are lacking. Here, we demonstrate progress toward this elusive goal by targeting a noncatalytic cysteine in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83acadbd6e4eba9e99e2adc9c4909438
https://escholarship.org/uc/item/45z2k97q
https://escholarship.org/uc/item/45z2k97q
Autor:
Nicholas F. Paoni, Ralph H. Schwall, Jo-Anne Hongo, Gladys Ingle, Constance H. Zlot, Suya Yang, Zhong Sheng, Mary E. Gerritsen, Franklin Peale, Fay Wang
Publikováno v:
Journal of Biological Chemistry. 278:47654-47659
Stanniocalcin 1 (STC1) is a secreted glycoprotein originally described as a hormone involved in calcium and phosphate homeostasis in bony fishes. We recently identified the mammalian homolog of this molecule to be highly up-regulated in an in vitro m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96d0e6124eac5323d02d50e942123091
https://doi.org/10.1074/jbc.m301353200
https://doi.org/10.1074/jbc.m301353200
Publikováno v:
British Journal of Pharmacology. 140:595-610
Hepatocyte growth factor (HGF) and vascular endothelial cell growth factor (VEGF) are two potent endothelial mitogens with demonstrated angiogenic activities in animal models of therapeutic angiogenesis. Several recent studies suggest that these grow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a0b700751a0c65d0edc3f1471fa4a084
https://doi.org/10.1038/sj.bjp.0705494
https://doi.org/10.1038/sj.bjp.0705494
Autor:
Scott M. Wasserman, Ruey-Bing Yang, Mary E. Gerritsen, James N. Topper, Chi Kin Domingos Ng, László G. Kömüves
Publikováno v:
Journal of Biological Chemistry. 278:33232-33238
We have previously utilized a combination of high throughput sequencing and genome-wide microarray profiling analyses to identify novel cell-surface proteins expressed in human umbilical vein endothelial cells. One gene identified by this approach en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30bb4da38b2e3ff4b9aa387ecc049ac2
https://doi.org/10.1074/jbc.m305022200
https://doi.org/10.1074/jbc.m305022200