Decreased Embryonic Splicing Repressor Expression Enhances Splicing Modulator Sensitivity in Pediatric Acute Myeloid Leukemia Stem Cells

Autor: Inge Van Der Werf, Kathleen Steel, Phoebe Mondala, Larissa Balaian, Jacqueline Cloos, Gertjan J.L. Kaspers, James La Clair, Peggy Wentworth, Kathleen Fisch, Leslie Crews, Thomas Whisenant, Michael Burkart, Mary Donohoe, Catriona Jamieson

Publikováno v: Blood. 140:3354-3355

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0642da34db5d821bfd620c5b49d4d3fe
https://doi.org/10.1182/blood-2022-171145

Deregulation of Splicing in Pediatric Acute Myeloid Stem and Progenitor Cells

Autor: Cayla Mason, Phoebe Mondala, Inge van der Werf, Ruben van Boxtel, Markus J van Roosmalen, Kathleen M. Fisch, Jacqueline Cloos, Adam Mark, Raymond Diep, Larisa Balaian, James J. La Clair, Leslie Crews, Gertjan J.L. Kaspers, Luisa Ladel, Catriona Jamieson, Warren C. W. Chan, Kathleen Steel, Thomas Whisenant, Peggy Wentworth, Mary Donohoe, Michael D. Burkart

Publikováno v: Mondala, P, Van Der Werf, I, Balaian, L, Steel, K, Ladel, L, Mason, C, Diep, R, Cloos, J, Kaspers, G, van Roosmalen, M J, Van Boxtel, R, Chan, W, Mark, A, Donohoe, M, La Clair, J, Wentworth, P, Fisch, K, Crews, L A, Whisenant, T, Burkart, M & Jamieson, C 2021, ' Deregulation of Splicing in Pediatric Acute Myeloid Stem and Progenitor Cells ', Blood, vol. 138 . https://doi.org/10.1182/blood-2021-154120
Blood, 138. American Society of Hematology

Currently, the limited capacity of pediatric acute myeloid leukemia (AML) therapies to prevent recurrence has contributed to high mortality rates. While dormant self-renewing leukemia stem cells (LSCs) contribute to adult AML relapse, their role in p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d410fc7237fa86fcd9dbbeb5e49ba660
https://doi.org/10.1182/blood-2021-154120

Inflammation-driven deaminase deregulation fuels human pre-leukemia stem cell evolution

Autor: Guorong Xu, Kathleen M. Fisch, Isabella Jamieson Morris, Catriona Jamieson, Raymond Diep, Chanond A Nasamran, Ruben A. Mesa, Frida Holm, Amanda Birmingham, Jessica Pham, Wenxue Ma, Jane Isquith, Cayla Mason, Eduardo Reynoso, Yudou He, Phoebe Mondala, Roman Sasik, Sara Brin Rosenthal, Adam Mark, Mary Donohoe, Ludmil B. Alexandrov, Gabriel Pineda, Isabelle Oliver, J. Craig Venter, Luisa Ladel, Sanja Coso, Thomas Whisenant, Qingfei Jiang, Shawn Ali, Leslie Crews

Publikováno v: Cell Rep
Cell reports, vol 34, iss 4

Inflammation-dependent base deaminases promote therapeutic resistance in many malignancies. However, their roles in human pre-leukemia stem cell (pre-LSC) evolution to acute myeloid leukemia stem cells (LSCs) had not been elucidated. Comparative whol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28c8a3836b4f9eb21f3c5ba362f46b32
https://doi.org/10.1016/j.celrep.2020.108670

Abstract 3792: Imetelstat inhibits RNA-editing mediated myeloproliferative neoplasm stem cell self-renewal

Autor: Catriona Jamieson, Edward D. Ball, Cayla Mason, Phoebe Mondala, Fei Huang, Jeremy Lee, Wenxue Ma, Benjamin Heyman, Sheldon R. Morris, Jessica Pham, Raymond Diep, Thomas Whisenant, Qingfei Jiang, Ping Chen, Larisa Balaian, Mary Donohoe

Publikováno v: Cancer Research. 80:3792-3792

Introduction: Myeloproliferative neoplasms (MPN) including blast crisis (BC) CML and myelofibrosis (MF) are characterized by the clonal proliferation of hematopoietic cell lineages, mostly in the marrow. BC CML gives rise to TKI resistant myeloid pro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7fbf32aaa81f5829215af0f260277768
https://doi.org/10.1158/1538-7445.am2020-3792

Children's perceptions of teachers

Autor: Derval McHale, Fionnuala Ní Chonaire, Concepta Ní Eanachain, Hugh Gash, Rois Leonard, Sinéad Trimble, Mary Donohoe, Olive Fenton

Publikováno v: Irish Educational Studies. 9:70-75

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::62d0d50041212efa1a6c47c5259205ff
https://doi.org/10.1080/0332331900090109