Výsledky vyhledávání

Senolytic administration following doxorubicin chemotherapy prevents large elastic artery stiffening and endothelial dysfunction

Autor: Ravinandan Venkatasubramanian, Sophia Mahoney, Grace Maurer, Mary Darrah, Katelyn Ludwig, Nicholas VanDongen, Matthew Rossman, Vienna Brunt, Judith Campisi, Douglas Seals, Zachary Clayton

Publikováno v: Physiology. 38

Doxorubicin (DOXO) chemotherapy induces vascular dysfunction (aortic stiffening and endothelial dysfunction). Cellular senescence and the related increase in oxidative stress, notably mitochondrial reactive oxygen species (mtROS), are implicated in D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b9c9c23b245c492b47948bcb507450a3
https://doi.org/10.1152/physiol.2023.38.s1.5733334

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25-Hydroxycholesterol reduces aortic cellular senescence and stiffness in old mice

Autor: Sophia Mahoney, Serban Ciotlos, Mary Darrah, Ravinandan Venkatasubramanian, Matthew Rossman, Judith Campisi, Douglas Seals, Simon Melov, Zachary Clayton

Publikováno v: Physiology. 38

Aortic stiffnessincreases with aging and is an independent risk factor for the development of cardiovascular diseases. Cellular senescence, a state of cell cycle arrest that accumulates in arteries with aging, contributes to age-related aortic stiffe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c8a46dd8200005b33d7d195efc01e0cd
https://doi.org/10.1152/physiol.2023.38.s1.5711505

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