Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Mary D. Davis"'
Autor:
Jing Zhao, Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary D. Davis, Chia-Chen Liu, Wenyan Lu, Xue Wang, Kai Chen, Yesesri Cherukuri, Lin Jia, Yuka A. Martens, Lucy Job, Francis Shue, Thanh Thanh Nguyen, Steven G. Younkin, Neill R. Graff-Radford, Zbigniew K. Wszolek, David A. Brafman, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun Bu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
APOE4 is a strong genetic risk factor for late-onset Alzheimer’s disease. Here, the authors show that APOE4 is associated with AD features in hiPSCs-derived cerebral organoids. Isogenic conversion of APOE4 to APOE3 attenuates the AD-associated phen
Externí odkaz:
https://doaj.org/article/6279c67f0fd74c15a58ff8bbebdd96ab
Autor:
Jing Zhao, Yuan Fu, Yu Yamazaki, Yingxue Ren, Mary D. Davis, Chia-Chen Liu, Wenyan Lu, Xue Wang, Kai Chen, Yesesri Cherukuri, Lin Jia, Yuka A. Martens, Lucy Job, Francis Shue, Thanh Thanh Nguyen, Steven G. Younkin, Neill R. Graff-Radford, Zbigniew K. Wszolek, David A. Brafman, Yan W. Asmann, Nilüfer Ertekin-Taner, Takahisa Kanekiyo, Guojun Bu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Externí odkaz:
https://doaj.org/article/7d132e45c6ff45cfac7ff65530b807ac
Autor:
Guojun Bu, Wenyan Lu, Xianlin Han, Jing Zhao, Xue Wang, Mary D. Davis, Meixia Pan, Nilufer Ertekin-Taner, Steven G. Younkin, Chia Chen Liu, Fuyao Li, Zbigniew K. Wszolek, Yuka A. Martens, Yan W. Asmann, Ziying Xu, Yuan Fu, Kai Chen, Neill R. Graff-Radford, Francis Shue, David A. Brafman, Takahisa Kanekiyo, Yingxue Ren, Dennis W. Dickson
Publikováno v:
Acta Neuropathologica
Acta Neuropathol
Acta Neuropathol
APOE4 is a strong genetic risk factor for Alzheimer’s disease and Dementia with Lewy bodies; however, how its expression impacts pathogenic pathways in a human-relevant system is not clear. Here using human iPSC-derived cerebral organoid models, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b6674131ee16462e9d4bf9698efe348
http://europepmc.org/articles/PMC8500881
http://europepmc.org/articles/PMC8500881
Autor:
Mary D. Davis, Yan W. Asmann, Guojun Bu, Yuan Fu, Nilufer Ertekin-Taner, Zbigniew K. Wszolek, Jing Zhao, Meixia Pan, Kai Chen, Chia Chen Liu, Neill R. Graff-Radford, Yingxue Ren, Fuyao Li, Dennis W. Dickson, Steven G. Younkin, Takahisa Kanekiyo, Xianlin Han, Francis Shue, Yuka A. Martens, Wenyan Lu, Ziying Xu, David A. Brafman, Xue Wang
Publikováno v:
Acta Neuropathologica. 143:119-121
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ceaff2850c8f0422d75193af781d5d7b
https://doi.org/10.1007/s00401-021-02380-6
https://doi.org/10.1007/s00401-021-02380-6
Autor:
Yuan Fu, Lin Jia, Dennis W. Dickson, Mariet Allen, Jing Zhao, Akari Yamazaki, Takahisa Kanekiyo, Guojun Bu, Melissa C. Wren, Cynthia Linares, Yu Yamazaki, Lindsey M. Felton, Chia Chen Liu, Michael G. Heckman, Wenhui Qiao, Melissa E. Murray, Hongmei Li, Na Wang, Mary D. Davis, Nilufer Ertekin-Taner, Hiroshi Oue, Tomonori Aikawa, Minerva M. Carrasquillo, Ronald C. Petersen, Nancy N. Diehl, Na Zhao, Yonghe Li, Yuka A. Martens, Michael DeTure, Marie Louise Holm
Publikováno v:
Alzheimer's & dementia : the journal of the Alzheimer's Association
Introduction Cerebrovascular pathologies including cerebral amyloid angiopathy (CAA) and blood-brain barrier (BBB) dysregulation are prominent features in the majority of Alzheimer's disease (AD) cases. Methods We performed neuropathologic and bioche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::589fdcbc84c1fa14b7f000cebac1ac69
http://europepmc.org/articles/PMC8103951
http://europepmc.org/articles/PMC8103951
Autor:
Yan W. Asmann, Yuan Fu, Wenyan Lu, Francis Shue, Yesesri Cherukuri, Nilufer Ertekin-Taner, Yuka A. Martens, Chia Chen Liu, Jing Zhao, Guojun Bu, Lin Jia, Neill R. Graff-Radford, Zbigniew K. Wszolek, Yu Yamazaki, Takahisa Kanekiyo, Mary D. Davis, Lucy Job, Yingxue Ren, Steven G. Younkin, David A. Brafman, Thanh Thanh L. Nguyen, Kai Chen, Xue Wang
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer’s disease (AD). To address the underlying mechanism, we develop cerebral organoid models using induced pluripotent stem cells (iPSCs) with APOE ε3/ε3 or ε4/ε4 genot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c5c569567ddee78d524fb6eb5f4fb8
https://doi.org/10.1038/s41467-020-19264-0
https://doi.org/10.1038/s41467-020-19264-0
Autor:
Jing Zhao, Mary D. Davis, Neill R. Graff-Radford, Yuka A. Martens, Mitsuru Shinohara, Takahisa Kanekiyo, Guojun Bu, Steven G. Younkin, Zbigniew K. Wszolek
Publikováno v:
Human Molecular Genetics. 26:2690-2700
The ε4 allele of the APOE gene encoding apolipoprotein E (apoE) is a strong genetic risk factor for aging-related cognitive decline as well as late-onset Alzheimer's disease (AD) compared to the common ε3 allele. In the central nervous system, apoE
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::133ee997ceccd977858040e3c64713af
https://doi.org/10.1093/hmg/ddx155
https://doi.org/10.1093/hmg/ddx155
Autor:
Mary D. Davis, Chia Chen Liu, Joshua Knight, Aishe Kurti, Fuyao Li, Guojun Bu, Cynthia Linares, Wenhui Qiao, John D. Fryer, Olivia N. Attrebi, Yingxue Ren, Marion Delenclos, Jiaying Zheng, Yan W. Asmann, Dennis W. Dickson, Pamela J. McLean, Owen A. Ross, Na Zhao, Francis Shue, Axel D. Meneses, Berkiye Sonustun, Yuka A. Martens, Yixing Chen, Alexandra J. Van Ingelgom
Publikováno v:
Sci Transl Med
The apolipoprotein E (APOE) ε4 allele is the strongest genetic risk factor for late-onset Alzheimer’s disease mainly by driving amyloid-β pathology. Recently, APOE4 has also been found to be a genetic risk factor for Lewy body dementia (LBD), whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d62676212be5002c8a8702f5c6ae0bc0
https://pubmed.ncbi.nlm.nih.gov/32107475
https://pubmed.ncbi.nlm.nih.gov/32107475
Autor:
Li Li, Zbigniew K. Wszolek, Chung Han Hsieh, Roeland Vanhauwaert, Xinnan Wang, Mary D. Davis, Kong T. Nguyen, Guojun Bu
Publikováno v:
Cell Metab
The identification of molecular targets and pharmacodynamic markers for Parkinson’s disease (PD) will empower more effective clinical management and experimental therapies. Miro1 is localized on the mitochondrial surface and mediates mitochondrial
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::599657d3a9560ac9a3833e2cb409d305
https://pubmed.ncbi.nlm.nih.gov/31564441
https://pubmed.ncbi.nlm.nih.gov/31564441
Autor:
Lucy Job, Yan W. Asmann, Takahisa Kanekiyo, Yuan Fu, David A. Brafman, Nilufer Ertekin-Taner, Zbigniew K. Wszolek, Yesesri Cherukuri, Francis Shue, Yingxue Ren, Kai Chen, Wenyan Lu, Mary D. Davis, Yuka A. Martens, Yu Yamazaki, Chia Chen Liu, Steven G. Younkin, Lin Jia, Jing Zhao, Guojun Bu, Neill R. Graff-Radford, Thanh Thanh L. Nguyen, Xue Wang
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-1 (2021)
Nature Communications
Nature Communications
APOE4 is the strongest genetic risk factor associated with late-onset Alzheimer's disease (AD). To address the underlying mechanism, we develop cerebral organoid models using induced pluripotent stem cells (iPSCs) with APOE ε3/ε3 or ε4/ε4 genotyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95279af2660dda8c2eb0a155f0af4e1
https://doaj.org/article/7d132e45c6ff45cfac7ff65530b807ac
https://doaj.org/article/7d132e45c6ff45cfac7ff65530b807ac