Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mary Castillo"'
Autor:
Lauren E Fitch, Vincent M. Isabella, Kristin J. Adolfsen, Munira Momin, Teodelinda Mirabella, Adam G Lawrence, James E. Spoonamore, Per Jr Greisen, Andres Abin-Fuentes, Isolde Callihan, Mary Castillo, Lauren Renaud, Carl J Weile, Catherine E Monahan, Lindong Weng, Jay H Konieczka
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
In phenylketonuria (PKU) patients, a genetic defect in the enzyme phenylalanine hydroxylase (PAH) leads to elevated systemic phenylalanine (Phe), which can result in severe neurological impairment. As a treatment for PKU, Escherichia coli Nissle (EcN
Autor:
Aoife M. Brennan, Larry Blankstein, Mark R. Charbonneau, Mary Castillo, John A. Phillips, Benjamin D. Goodlett, William S. Denney, Caroline B. Kurtz, David A. Wagner, Jerry Vockley, Marja K. Puurunen, Stephanie Sacharow, Vincent M. Isabella, Vasu V. Sethuraman, Richard Riese, Shawn Searle
Publikováno v:
Nature Metabolism. 3:1125-1132
Phenylketonuria (PKU) is a rare disease caused by biallelic mutations in the PAH gene that result in an inability to convert phenylalanine (Phe) to tyrosine, elevated blood Phe levels and severe neurological complications if untreated. Most patients
Autor:
Elaine A. Merrill, Peter J Robinson, Camilla A Mauzy, Heidi G. Coia, Corey Holt, Eric S. Greenwood, Mark R. Charbonneau, Mary Castillo, David Lubkowicz, M. Tyler Nelson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications
Nature Communications
Engineered bacteria (synthetic biotics) represent a new class of therapeutics that leverage the tools of synthetic biology. Translational testing strategies are required to predict synthetic biotic function in the human body. Gut-on-a-chip microfluid
Autor:
Aoife M. Brennan, Nicholas G. Horvath, William S. Denney, Mary Castillo, Pasquale Cantarella, Mark R. Charbonneau, Marja K. Puurunen
Publikováno v:
Communications Biology
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
Communications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
The development of therapeutics depends on predictions of clinical activity from pre-clinical data. We have previously described SYNB1618, an engineered bacterial therapeutic (synthetic biotic) for the treatment of Phenylketonuria (PKU), a rare genet
Autor:
Paul F. Miller, Mary Castillo, Caroline B. Kurtz, Kip A. West, Philippa J. Reeder, Binh Ha, Adam B. Fisher, Yves Millet, Vincent M. Isabella, Cami Leigh Anderson, David Lubkowicz, Dean Falb, Sarah Rowe, Christopher Bergeron, Sarah E. Guilmain, Ning Li, Munira Momin
Publikováno v:
Nature Biotechnology. 36:857-864
Phenylketonuria (PKU) is a genetic disease that is characterized by an inability to metabolize phenylalanine (Phe), which can result in neurotoxicity. To provide a potential alternative to a protein-restricted diet, we engineered Escherichia coli Nis
Autor:
Putman Ryan, Carlin Dylan Alexander, Patrick M. Boyle, Silvia Galvan, Michael J. James, Caroline B. Kurtz, Ning Li, Christopher Bergeron, Kolea Zimmerman, Jain Rishi, Lauren Renaud, Mary Castillo, Mylene Perreault, Jian-Rong Gao, Tucker Alex C, Laura Stone, Scott Marr
Metabolic dysfunction arising from missing or impaired enzymes comprising the branched chain amino acid (BCAA) degradation pathway, especially those involving leucine, can result in the accumulation of toxic metabolic intermediates and cause severe m
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9db14f5bda666cb0897ab3cf478b0afc
https://doi.org/10.21203/rs.3.rs-318620/v1
https://doi.org/10.21203/rs.3.rs-318620/v1
Autor:
Mary Castillo, Adam B. Fisher, Paul S. Miller, Starsha Kolodziej, Ning Li, Jose M. Lora, Daniel S. Leventhal, Carey W. Gallant, Anna Sokolovska, Chris Plescia, Kip A. West
Publikováno v:
Cancer Research. 78:LB-131
Background: While both T-cell priming and blockade of immune suppression play critical roles in the generation of an efficacious antitumor immune response, most therapies fail to support both processes as a single agent. At Synlogic we are using synt
Autor:
Mary Castillo, Vincent M. Isabella, Jose M. Lora, Ning Li, Paul S. Miller, Chris Plescia, Kip A. West, Anna Sokolovska, Dan Leventhal, Starsha Kolodziej, Adam B. Fisher
Publikováno v:
Cancer Research. 78:2920-2920
Background: The immunosuppressive milieu found within the tumor microenvironment (TME) has long been understood to be a key driver of tumor initiation and progression. More recently it has been appreciated that metabolites derived from biosynthetic p
Autor:
John V. Thomas, Jose M. Lora, Binh Ha, Paul S. Miller, Lauren Renaud, Caroline B. Kurtz, Mary Castillo, Denise Wong, Yves Millet, Yossi Dagon
Publikováno v:
Gastroenterology. 154:S-1078
Whether they're flirting en espanol, gossiping over mojitos, or dancing with their latest papi chulos, the characters in Friday Night Chicas prove that there is nothing quite like a night out with your chicas. Set in New York City, Miami's South Beac