Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Mary Carioto"'
Autor:
Christopher A. Alabi, Tatiana Novobrantseva, Roman L. Bogorad, William Querbes, Weiheng Wang, Abigail K. R. Lytton-Jean, Daniel G. Anderson, Avi Schroeder, Akin Akinc, Arturo J. Vegas, Hao Yin, Carmen Barnes, Yi Chen, Delai Chen, Kevin Fitzgerald, J. Robert Dorkin, June Qin, Scott A Barros, Victor Koteliansky, Yizhou Dong, Robert Langer, Julia Hettinger, Sasilada Sirirungruang, Gaurav Sahay, Kevin T. Love, Daniel J. Siegwart, Mary Carioto, Varun Kumar, Yunlong Zhang, Karsten Olejnik
Publikováno v:
Proceedings of the National Academy of Sciences. 111:3955-3960
siRNA therapeutics have promise for the treatment of a wide range of genetic disorders. Motivated by lipoproteins, we report lipopeptide nanoparticles as potent and selective siRNA carriers with a wide therapeutic index. Lead material cKK-E12 showed
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40bcc7ad1c737c8c82f110498a4ee39a
https://doi.org/10.1073/pnas.1322937111
https://doi.org/10.1073/pnas.1322937111
Autor:
Amy Simon, Brian C. Cooley, Akin Akinc, Julia Hettinger, Renta Hutabarat, Yongfeng Jiang, Rachel Meyers, June Qin, Mary Carioto, Martin Maier, Klaus Charisse, Harsha K. Prabhala, Husain Attarwala, Rodney M. Camire, Lubo Nechev, Pachamuthu Kandasamy, Lacramioara Ivanciu, Alexander V Kel'in, Muthiah Manoharan, Kallanthottathil G. Rajeev, Scott A Barros, Jayaprakash K. Nair, Don Foster, Satya Kuchimanchi, Yesim Dargaud, Xuemei Zhang, Benny Sørensen, Tim Racie, Stuart Milstein, Alfica Sehgal, Claude Negrier, Josh Brodsky
Publikováno v:
Nature medicine. 21(5)
Hemophilia A and B are inherited bleeding disorders characterized by deficiencies in procoagulant factor VIII (FVIII) or factor IX (FIX), respectively. There remains a substantial unmet medical need in hemophilia, especially in patients with inhibito
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4aa616e2a51cb586e3970c1386fe429
https://pubmed.ncbi.nlm.nih.gov/25849132
https://pubmed.ncbi.nlm.nih.gov/25849132
Autor:
Yongfeng Jiang, June Qin, Harsha K. Prabhala, Akin Akinc, Julia Hettinger, Mary Carioto, Scott A Barros, Alfica Sehgal
Publikováno v:
Blood. 122:3585-3585
ALN-AT3, a subcutaneously administered RNAi therapeutic targeting antithrombin (AT), is currently being developed for the treatment of hemophilia and rare bleeding disorders. It has previously been demonstrated that once weekly dosing of ALN-AT3 resu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::466e3397555f263bd0307cca4c1e8b39
https://doi.org/10.1182/blood.v122.21.3585.3585
https://doi.org/10.1182/blood.v122.21.3585.3585