Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mary C. Wolff"'
Publikováno v:
NeuroReport. 16:63-67
Environmental enrichment enhances learning and memory in both rodents and man. We examined the effect of active manipulation of a novel object (toy) on cognitive performance and acetylcholine (ACh) efflux in the hippocampus of rats. Animals exposed t
Autor:
Mary C. Wolff, J. David Leander
Publikováno v:
Neuropsychopharmacology. 27:421-429
The inability to delay gratification (reinforcement or reward) is one index of impulsive behavior. In order to measure the willingness of pigeons to delay reinforcement, an adjustable delay schedule was developed that allowed daily approximations of
Autor:
Mary C. Wolff, J. D. Leander
Publikováno v:
Psychopharmacology. 146:275-279
Rationale: Understanding the contribution of the various serotonin (5-HT) receptor subtypes to the behavioral effects of selective serotonin reuptake inhibitors (SSRIs) may contribute to the discovery of increasingly effective drugs for the treatment
Autor:
Mary C. Wolff, J. David Leander
Publikováno v:
European Journal of Pharmacology. 345:35-39
The effects of two selective serotonin reuptake inhibitors, fluoxetine and citalopram, and a nonselective monoamine reuptake inhibitor, imipramine, were characterized in pigeons that had been trained to discriminate 0.64 mg/kg of 8-hydroxy-(2-di- n -
Autor:
Mary C. Wolff, J. David Leander
Publikováno v:
European Journal of Pharmacology. 340:217-220
LY228729 [(−)-4(dipropylamino)-1,3,4,5-tetrahydrobenz-{c,d}indole-6-carboxamide}], an agonist at the 5-HT 1A subtype of 5-HT receptor, was studied as an antiemetic in pigeons dosed with a highly emetic oncolytic agent, cyclophosphamide. An intramus
Autor:
Mary C. Wolff, J. David Leander
Publikováno v:
European Journal of Pharmacology. 333:113-122
Pigeons were trained to discriminate 0.64 mg/kg (high dose) of 8-OH-DPAT (8-hydroxy-(2-di-n-propylamino)tetralin) from saline or were retrained to discriminate 0.16 mg/kg (low dose) of 8-OH-DPAT from saline. This resulted in a decrease of the ED50 fo
Autor:
David O. Calligaro, David L. Nelson, Susan K. Hemrick-Luecke, Mary C. Wolff, James B. Lucot, Jaswant Singh Gidda, Mark J. Benvenga, Carl D Overshiner, Ray W. Fuller, J. David Leander
Publikováno v:
Drug Development Research. 40:17-34
LY301317 ((4r)-(-)-4-(dipropylamino)-6-(5-oxazolinyl)-1,3,4,5-tetrahydrobenz[c,d]indole) has high affinity for the 5-HT 1A receptor and weak affinity for the 5-HT 1D and histamine-H 1 receptors. No significant affinity was found for the other amine r
Autor:
J D Leander, Mary C. Wolff
Publikováno v:
Pharmacology Biochemistry and Behavior. 52:571-575
Vomiting may be induced by a variety of agents such as drugs, oncolytics, and provocative motion, as well as being conditioned to occur to environmental stimuli. Such emesis has recently been shown to be blocked by agonists at the 5-HT1A subtype of s
Publikováno v:
Pharmaceutical Sciences Encyclopedia
Statistical parameters estimated in validation studies to establish the reliability of single-concentration assays, such as the Signal Window and Z'-Factor, are well established. These statistics do not ensure that potency estimates from concentratio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::425fe8576e84928eaaaa825f7556b2c3
https://doi.org/10.1002/9780470571224.pse016
https://doi.org/10.1002/9780470571224.pse016
Autor:
Mary C. Wolff, J. David Leander
Publikováno v:
European journal of pharmacology. 477(3)
An endogenous cannabinoid system may play an important role in controlling memory processes. SR141716A (N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamidehydrochloride), a selective cannabinoid CB(1) recep