Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Mary C. Horne"'
Autor:
Victor A. Flores‐Tamez, Miguel Martín‐Aragón Baudel, Junyoung Hong, Jade L. Taylor, Lu Ren, Thanhmai Le, Arsalan U. Syed, Yumna Moustafa, Navid Singhrao, Wendy R. Lemus‐Martinez, Gopireddy R. Reddy, Victoria Ramer, Kwun Nok Mimi Man, Peter Bartels, Ye Chen‐Izu, Chao‐Yin Chen, Sergi Simo, Eamonn J. Dickson, Stefano Morotti, Eleonora Grandi, L. Fernando Santana, Johannes W. Hell, Mary C. Horne, Madeline Nieves‐Cintrón, Manuel F. Navedo
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 13, Iss 20 (2024)
Background Increased vascular CaV1.2 channel function causes enhanced arterial tone during hypertension. This is mediated by elevations in angiotensin II/protein kinase C signaling. Yet, the mechanisms underlying these changes are unclear. We hypothe
Externí odkaz:
https://doaj.org/article/3442030d4e57470fb2eaf2e11402d37c
Publikováno v:
F1000Research, Vol 6 (2018)
Background: The L-type Ca2+ channel Cav1.2 is a prominent regulator of neuronal excitability, synaptic plasticity, and gene expression. The central element of Cav1.2 is the pore-forming α11.2 subunit. It exists in two major size forms, whose molecul
Externí odkaz:
https://doaj.org/article/cf4f740fc3774f34aecc813584a3d9dc
Publikováno v:
F1000Research, Vol 6 (2017)
Background: The L-type Ca2+ channel Cav1.2 is a prominent regulator of neuronal excitability, synaptic plasticity, and gene expression. The central element of Cav1.2 is the pore-forming α11.2 subunit. It exists in two major size forms, whose molecul
Externí odkaz:
https://doaj.org/article/36b867a70dc34d9eb6b1b380773a6f51
Autor:
Kwun Nok Mimi Man, Peter Bartels, Peter B Henderson, Karam Kim, Mei Shi, Mingxu Zhang, Sheng-Yang Ho, Madeline Nieves-Cintron, Manuel F Navedo, Mary C Horne, Johannes W Hell
Publikováno v:
eLife, Vol 12 (2023)
The cellular mechanisms mediating norepinephrine (NE) functions in brain to result in behaviors are unknown. We identified the L-type Ca2+ channel (LTCC) CaV1.2 as a principal target for Gq-coupled α1-adrenergic receptors (ARs). α1AR signaling incr
Externí odkaz:
https://doaj.org/article/3817fb9d55da497485e8cde29a419fb9
Autor:
Taylor L. Voelker, Silvia G. del Villar, Maartje Westhoff, Alexandre D. Costa, Andrea M. Coleman, Johannes W. Hell, Mary C. Horne, Eamonn J. Dickson, Rose E. Dixon
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Ca V 1.2 channels are critical players in cardiac excitation–contraction coupling, yet we do not understand how they are affected by an important therapeutic target of heart failure drugs and regulator of blood pressure, angiotensin II. Signaling t
Autor:
Peter Bartels, Ian Salveson, Andrea M. Coleman, David E. Anderson, Grace Jeng, Zoila M. Estrada-Tobar, Kwun Nok Mimi Man, Qinhong Yu, Elza Kuzmenkina, Madeline Nieves-Cintron, Manuel F. Navedo, Mary C. Horne, Johannes W. Hell, James B. Ames
Publikováno v:
The Journal of biological chemistry, vol 298, iss 12
The L-type Ca2+ channel CaV1.2 controls gene expression, cardiac contraction, and neuronal activity. Calmodulin (CaM) governs CaV1.2 open probability (Po) and Ca2+-dependent inactivation (CDI) but the mechanisms remain unclear. Here, we present elect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f051a5dc802d62dbb779f0a8225b2a42
https://escholarship.org/uc/item/06t096dz
https://escholarship.org/uc/item/06t096dz
Autor:
Peter, Bartels, Ian, Salveson, Andrea M, Coleman, David E, Anderson, Grace, Jeng, Zoila M, Estrada-Tobar, Kwun Nok, Mimi Man, Qinhong, Yu, Elza, Kuzmenkina, Madeline, Nieves-Cintron, Manuel F, Navedo, Mary C, Horne, Johannes W, Hell, James B, Ames
Publikováno v:
The Journal of biological chemistry.
The L-type Ca
Autor:
Kwun Nok Mimi Man, Peter B. Henderson, Karam Kim, Mei Shi, Mingxu Zhang, Madeline Nieves-Cintron, Manuel F. Navedo, Mary C. Horne, Johannes W. Hell
The cellular mechanisms mediating norepinephrine functions in brain to result in behaviors are unknown. We identified the L-type Ca2+ channel (LTCC) CaV1.2 as a principal target for Gq- coupled α1-adrenergic receptors (ARs). α1AR signaling increase
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b3b84f0b8777ce98da1681b568597b74
https://doi.org/10.1101/2022.07.01.498400
https://doi.org/10.1101/2022.07.01.498400
Autor:
Peter Bartels, Ian Salveson, Andrea M. Coleman, David E. Anderson, Grace Jeng, Zoila M. Estrada-Tobar, Kwun Nok Mimi Man, Qinhong Yu, Elza Kuzmenkina, Madeline Nieves-Cintron, Manuel F. Navedo, Mary C. Horne, Johannes W. Hell, James B. Ames
The L-type Ca2+ channel CaV1.2 controls gene expression, cardiac contraction, and neuronal activity. Calmodulin (CaM) governs CaV1.2 open probability (Po) and Ca2+-dependent inactivation (CDI) but the mechanisms remain unclear. We identified a half C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::47b3129855c74710ca7ee907bee1418c
https://doi.org/10.1101/2022.06.24.497440
https://doi.org/10.1101/2022.06.24.497440
Publikováno v:
Annual Review of Pharmacology and Toxicology. 60:155-174
Formation of signaling complexes is crucial for the orchestration of fast, efficient, and specific signal transduction. Pharmacological disruption of defined signaling complexes has the potential for specific intervention in selected regulatory pathw