Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Mary C. French"'
Publikováno v:
Neurochemistry International. 18:265-273
The protective effects of two dose regimes of the organophosphate pretreatment combination, physostigmine and hyoscine, were assessed on the central neurochemical changes produced following soman intoxication. The lower dose combination (physostigmin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8a06835d3d583baf018c2d82347ae6f
https://doi.org/10.1016/0197-0186(91)90194-i
https://doi.org/10.1016/0197-0186(91)90194-i
Autor:
Janet R. Wetherell, Mary C. French
Publikováno v:
Biochemical pharmacology. 42(3)
Plasma and red cells from a variety of animal species were used to demonstrate that there is a relationship between the decarbamoylation rates of physostigmine-inhibited plasma and red cell cholinesterases in vitro and the effectiveness of carbamate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::541fde54dc0d911421febe1b543f9196
https://pubmed.ncbi.nlm.nih.gov/1907148
https://pubmed.ncbi.nlm.nih.gov/1907148
Publikováno v:
Journal of neurochemistry. 54(1)
The effects of the organophosphate acetylcholinesterase (AChE) inhibitor soman (31.2 micrograms/kg s.c.) on guinea-pig brain AChE, transmitter, and metabolite levels were investigated. Concentrations of acetylcholine (ACh) and choline (Ch), noradrena
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::376c27ab03669444d2f235483e08e683
https://pubmed.ncbi.nlm.nih.gov/1967146
https://pubmed.ncbi.nlm.nih.gov/1967146
Publikováno v:
Journal of Pharmacy and Pharmacology. 31:295-299
The effectiveness of pyridostigmine pretreatment against soman poisoning has been determined in rhesus monkeys and marmosets receiving atropine therapy. Pretreatment with the maximum sign-free dose (200 μg kg−1, i.v.) raised the subcutaneous LD50
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac724ceda0855041e337a069885fd97c
https://doi.org/10.1111/j.2042-7158.1979.tb13504.x
https://doi.org/10.1111/j.2042-7158.1979.tb13504.x
Autor:
Mary C. French, Janet R. Wetherell
Publikováno v:
Biochemical Pharmacology. 35:939-945
The kinetic properties of cholinesterase (ChE) present in plasma were compared with those of purified human ChE using the substrates succinyldithiocholine (SDTCh), acetylthiocholine (AcTCh) and butyrylthiocholine (BuTCh). SDTCh was hydrolysed at two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b800a4eb06a0f09f1780cb4db6f03398
https://doi.org/10.1016/0006-2952(86)90080-8
https://doi.org/10.1016/0006-2952(86)90080-8
Publikováno v:
Journal of Pharmacy and Pharmacology. 31:290-294
The effect of pyridostigmine on neuromuscular block produced by soman was studied in the isolated phrenic nerve-diaphragm preparation. In the rat, soman produced an irreversible reduction in tetanic tension and functional acetylcholinesterase (AChE)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2b4373c817344c1163554e1aaa44d5c
https://doi.org/10.1111/j.2042-7158.1979.tb13503.x
https://doi.org/10.1111/j.2042-7158.1979.tb13503.x
Publikováno v:
British Journal of Pharmacology. 65:565-571
1. The effects of some muscarinic antagonists, namely, N-ethyl-2-pyrrolidylmethyl-cyclopentylphenyl glycollate (PMCG), N-methyl-4-piperidyl-phenylcyclohexyl glycollate (PPCG, racemate and R and S enantiomers) and 4'-N-methyl-piperidyl-1-phenyl-cyclop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a010c50738ffc38196fb6fff19f1f75
https://doi.org/10.1111/j.1476-5381.1979.tb07865.x
https://doi.org/10.1111/j.1476-5381.1979.tb07865.x
Publikováno v:
Journal of Neurochemistry. 53:1519-1526
Six brain areas of rats and guinea-pigs, killed by microwave irradiation, were used for the concomitant measurement of the levels and regional distribution of cholinergic, biogenic amine, and amino acid neurotransmitters and metabolites. Acetylcholin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4dcd0d125500e91607cec03739bb738d
https://doi.org/10.1111/j.1471-4159.1989.tb08547.x
https://doi.org/10.1111/j.1471-4159.1989.tb08547.x
The reversal by oximes and their de oximinomethyl analogues of neuromuscular block produced by soman
Publikováno v:
European Journal of Pharmacology. 91:399-409
A series of oximes and related compounds were assessed for their ability to restore soman-induced neuromuscular block in the isolated diaphragm preparation of the rat, guinea-pig and marmoset. In the rat the bispyridinium oximes HS6, H16 and HS14 wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c66c23b09eabd5b70bad81024a19f892
https://doi.org/10.1016/0014-2999(83)90164-4
https://doi.org/10.1016/0014-2999(83)90164-4
Publikováno v:
Psychopharmacology. 47:97-99
Significant differences in whole brain and in brain area acetylcholine concentration have been observed between the two strains of rats selectively bred for differences in speed of acquisition of conditioned avoidance. Brain acetylcholinesterase acti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::107141bf4fce087cb3a45bf51d0bc1af
https://doi.org/10.1007/bf00428709
https://doi.org/10.1007/bf00428709