Loss of the melanocortin-4 receptor in mice causes dilated cardiomyopathy

Autor: Michael J Litt, G Donald Okoye, Daniel Lark, Isin Cakir, Christy Moore, Mary C Barber, James Atkinson, Josh Fessel, Javid Moslehi, Roger D Cone

Publikováno v: eLife, Vol 6 (2017)

Haploinsufficiency of the melanocortin-4 receptor, the most common monogenetic obesity syndrome in humans, is associated with a reduction in autonomic tone, bradycardia, and incidence of obesity-associated hypertension. Thus, it has been assumed that

Externí odkaz: https://doaj.org/article/be1fdf60b9af4a499d962141b59a7a77

Development of ambient marine standards using long-term data: An example from Abu Dhabi

Autor: Glenn Whaley, Shaikha Al Hosani, Mary C. Barber, Wael Suleiman, Azza Al Raisi, Rajan Anbiah

Publikováno v: Aquatic Ecosystem Health & Management. 23:154-165

Abu Dhabi, the capital of the United Arab Emirates, has a coastline that occupies 76% of the country’s Arabian Gulf coastline. The pressures accompanying the economic development that the country is undergoing ultimately affected the marine ecosyst

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c670dc042d8d444e717c53eb4dcd25e2
https://doi.org/10.1080/14634988.2020.1794171

Collagen IVα345 dysfunction in glomerular basement membrane diseases. III. A functional framework for α345 hexamer assembly

Autor: Juan Saus, Tatiana Mikhailova, Billy G. Hudson, Jean-Christophe Harmange, Mary C Barber, Vadim Pedchenko, Sergei P. Boudko

Publikováno v: The Journal of Biological Chemistry

We identified a genetic variant, an 8-residue appendage, of the α345 hexamer of collagen IV present in patients with glomerular basement membrane (GBM) disease, Goodpasture's disease (GP) and Alport syndrome (AS) (see Companion Paper I), and determi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6bef66c227debf469ab7e2859d0b4a7c
http://europepmc.org/articles/PMC8099640

Cardiac arrhythmia considerations of hormone cancer therapies

Autor: Lee S. Nguyen, Joe-Elie Salem, Christian Funck-Brentano, Mary C Barber, Johanna Wassermann, Jean-Philippe Spano

Publikováno v: Cardiovascular Research
Cardiovascular Research, Oxford University Press (OUP), 2019, 115 (5), pp.878-894. ⟨10.1093/cvr/cvz020⟩
Cardiovascular Research, 2019, 115 (5), pp.878-894. ⟨10.1093/cvr/cvz020⟩

International audience; Breast and prostate cancers are among the most prevalent cancers worldwide. Oestradiol and progesterone are major drivers for breast cancer proliferation, and androgens for prostate cancer. Endocrine therapies are drugs that i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa78a541ddc8b1410053cdc3f4787c89
https://hal.sorbonne-universite.fr/hal-02153861

Resilience indicators support valuation of estuarine ecosystem restoration under climate change

Autor: Jennifer Richkus, LA Wainger, Cassie Gurbisz, David H. Secor, Patricia M. Glibert, Mary C. Barber, Edward D. Houde, W. M. Kemp

Publikováno v: Ecosystem Health and Sustainability, Vol 3, Iss 4 (2017)

Economic valuation of ecological restoration most often encompasses only the most tangible ecosystem service benefits, thereby omitting many difficult‐to‐measure benefits, including those derived from enhanced reliability of ecosystem services. B

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dfe7ccc6796d30c3478cfdd83c5853fc
https://doaj.org/article/200557d3550648bdb8d991b96ba89249