Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Mary C. Allen"'
Publikováno v:
British Journal of Pharmacology. 142:57-66
We determined (1) the inhibitory potency of zoniporide against the native Na+/H+ exchanger isoform 1 (NHE1) that is expressed in adult rat ventricular myocytes and platelets, and (2) the cardioprotective efficacy of zoniporide in isolated, blood-perf
Publikováno v:
The Journal of Clinical Pharmacology. 44:7-19
The authors tested 239 frequently used drugs and other compounds for their potential to inhibit the drug-metabolizing enzyme, aldehyde oxidase, in human liver cytosol. A sensitive, moderate throughput HPLC-MS assay was developed for 1-phthalazinone,
Publikováno v:
Biopharmaceutics & Drug Disposition. 20:319-326
CP-191,166 is an orally active, non-peptide angiotensin II (AII) receptor antagonist developed for the treatment of hypertension and congestive heart failure (CHF). In this study, the intravenous (iv) and oral (po) single dose pharmacokinetics (PK),
Autor:
Cassandra D. Salgado, Alice M. Boylan, Kathy Stockholm, Mary C. Allen, Linda Formby, Dee W. Ford, Janet Byrne
Publikováno v:
A39. IMPROVING QUALITY IN THE INTENSIVE CARE UNIT.
Autor:
Linda Formby, Mary C. Allen, Cassandra D. Salgado, Pamela J. Fogle, Michelle Engle, Bernadette Garry
Publikováno v:
American Journal of Infection Control. 42:S139-S140
Publikováno v:
British journal of pharmacology. 142(1)
1. We determined (1) the inhibitory potency of zoniporide against the native Na(+)/H(+) exchanger isoform 1 (NHE1) that is expressed in adult rat ventricular myocytes and platelets, and (2) the cardioprotective efficacy of zoniporide in isolated, blo
Autor:
Anthony A. Fossa, Ravi B. Marala, Delvin R. Knight, Donald E Frazier, Celeste Johnson, W. Ross Tracey, Angel Guzman-Perez, Mary C. Allen
Publikováno v:
Cardiovascular drug reviews. 21(1)
The sodium-hydrogen exchanger isoform-1 (NHE-1) plays an important role in the myocardial response to ischemia-reperfusion; inhibition of this exchanger protects against ischemic injury, including reduction in infarct size. Herein we describe a novel
Autor:
Bernadette Garry, Cassandra D. Salgado, Michelle Engle, Pamela J. Fogle, Linda Formby, Mary C. Allen
Publikováno v:
American Journal of Infection Control. 42:S62
Autor:
Ravi B. Marala, Allan R. Buchholz, Delvin R. Knight, Scott P. Kennedy, Wester Ronald Thure, Paul J. Kowalczyk, Roger J. Hill, Roger B. Ruggeri, Angel Guzman-Perez, Ewell R. Cook, Mary C. Allen, Day Wesley Warren, Janice A. Brown, Mularski Christian J, William Albert Novomisle, W. Ross Tracey, Hamanaka Ernest S
Publikováno v:
Bioorganicmedicinal chemistry letters. 11(6)
Zoniporide (CP-597,396) is a potent and selective inhibitor of NHE-1, which exhibits high aqueous solubility and acceptable pharmacokinetics for intravenous administration. The discovery, synthesis, activities, and rat and dog pharmacokinetics of thi
Publikováno v:
Journal of chromatography. B, Biomedical sciences and applications. 696(2)
Simple and precise high-performance liquid chromatographic (HPLC) assays were developed and validated for the determination of a renin inhibitor (RI), 4-cyclohexyl-2-hydroxy-3- (3-methylsulfanyl-2-[2-[(morpholine-4-carbonyl)amino]- 3-phenylpropionyla