Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Mary Brittain Blankenship"'
Autor:
Kristen C. Kelley, Kenneth F. Grossman, Mary Brittain-Blankenship, Kelli M. Thorne, Wallace L. Akerley, Moises C. Terrazas, Ken M. Kosak, Kenneth M. Boucher, Saundra S. Buys, Kimberly A. McGregor, Theresa L. Werner, Neeraj Agarwal, John R. Weis, Sunil Sharma, John H. Ward, Thomas P. Kennedy, Douglas W. Sborov, Paul J. Shami
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
Abstract Background Disulfiram and metals inactivate key oncoproteins resulting in anti-neoplastic activity. The goal of this study was to determine the maximum tolerated dose of copper when administered with disulfiram in patients with advanced soli
Externí odkaz:
https://doaj.org/article/1960d709654346b28eb07dc1080b90ac
Autor:
Kelli M. Thorne, John Harris Ward, Mary Brittain-Blankenship, Paul J. Shami, Sunil Sharma, Saundra S. Buys, Kenneth M. Boucher, Wallace Akerley, Kenneth Grossman, Ken M. Kosak, Kimberly McGregor, Neeraj Agarwal, Thomas P. Kennedy, Moises Terrazas, Theresa L. Werner, Kristen C. Kelley, Douglas W. Sborov, John R. Weis
Publikováno v:
BMC Cancer, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Cancer
BMC Cancer
BackgroundDisulfiram and metals inactivate key oncoproteins resulting in anti-neoplastic activity. The goal of this study was to determine the maximum tolerated dose of copper when administered with disulfiram in patients with advanced solid tumors a
Autor:
Wallace Akerley, Mary Brittain Blankenship, Kenneth M. Boucher, John R. Weis, Saundra S. Buys, Moises Terrazas, Theresa L. Werner, Neeraj Agarwal, Sunil Sharma, Paul J. Shami, Ken M. Kosak, John Harris Ward, Kimberly Jones, Kenneth F. Grossmann
Publikováno v:
Cancer Research. 71:1308-1308
Background: Disulfiram inhibits hepatic aldehyde dehydrogenase causing accumulation of acetaldehyde when alcohol is ingested and is used to treat alcohol addiction. When metal ions such as copper are combined with disulfiram, key oncoproteins are bou