Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Mary Beth Finn"'
Autor:
Tien-Phat V. Huynh, Chao Wang, Ainsley C. Tran, G. Travis Tabor, Thomas E. Mahan, Caroline M. Francis, Mary Beth Finn, Rebecca Spellman, Melissa Manis, Rudolph E. Tanzi, Jason D. Ulrich, David M. Holtzman
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-23 (2019)
Abstract Background The apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease (AD). ApoE is produced by both astrocytes and microglia in the brain, whereas hepatocytes produce the majority of apoE found in
Externí odkaz:
https://doaj.org/article/f357dfcc10784835afff3f46b50a633c
Autor:
Xiaoying Chen, Maria Firulyova, Melissa Manis, Jasmin Herz, Igor Smirnov, Ekaterina Aladyeva, Chanung Wang, Xin Bao, Mary Beth Finn, Hao Hu, Irina Shchukina, Min Woo Kim, Carla M. Yuede, Jonathan Kipnis, Maxim N. Artyomov, Jason D. Ulrich, David M. Holtzman
Publikováno v:
Nature. 615:668-677
Autor:
David M. Holtzman, Yang Shi, Melissa Manis, Tracy Cole, Tien Phat V. Huynh, Patrick Sullivan, Jason D. Ulrich, Bradley T. Hyman, Caroline M. Francis, Mary Beth Finn, Alexandra Litvinchuk, Rosemary J. Jackson, Ainsley C. Tran
Publikováno v:
Annals of Neurology. 89:952-966
OBJECTIVE Apolipoprotein E (ApoE) genotype is the strongest genetic risk factor for late-onset Alzheimer's disease, with the e4 allele increasing risk in a dose-dependent fashion. In addition to ApoE4 playing a crucial role in amyloid-β deposition,
Autor:
Richard E. Hartman, Aartie Shah, Anne M. Fagan, Katherine E. Schwetye, Maia Parsadanian, Risa N. Schulman, Mary Beth Finn, David M. Holtzman
Publikováno v:
Neurobiology of Disease, Vol 24, Iss 3, Pp 506-515 (2006)
Although there are no proven ways to delay onset or slow progression of Alzheimer's disease (AD), studies suggest that diet can affect risk. Pomegranates contain very high levels of antioxidant polyphenolic substances as compared to other fruits and
Externí odkaz:
https://doaj.org/article/2ed936a836b344daa90b65d955e9d860
Autor:
Rudolph E. Tanzi, Jason D. Ulrich, Thomas E. Mahan, Tien Phat V. Huynh, Chao Wang, Caroline M. Francis, Mary Beth Finn, Melissa Manis, G. Travis Tabor, David M. Holtzman, Ainsley C. Tran, Rebecca Spellman
Publikováno v:
Molecular Neurodegeneration, Vol 14, Iss 1, Pp 1-23 (2019)
Molecular Neurodegeneration
Molecular Neurodegeneration
BackgroundThe apolipoprotein E (APOE) gene is the strongest genetic risk factor for late-onset Alzheimer disease (AD). ApoE is produced by both astrocytes and microglia in the brain, whereas hepatocytes produce the majority of apoE found in the perip
Publikováno v:
Annals of Neurology. 85:291-295
Obstructive sleep apnea (OSA) increases risk of dementia, a relationship that may be mediated by amyloid-β (Aβ) and downstream Alzheimer disease pathology. We previously showed that OSA may impair Aβ clearance and affect the relationship between s
Autor:
David M. Holtzman, Floy R. Stewart, Cheryl E. G. Leyns, Lauren J. Koscal, Grace O. Robinson, Elise Anderson, Javier Remolina Serrano, Jason D. Ulrich, Mary Beth Finn, Marco Colonna
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance Alzheimer’s disease (AD) is the most common cause of dementia and is a major public health problem for which there is currently no disease-modifying treatment. There is an urgent need for greater understanding of the molecular mechanis
Obstructive sleep apnea decreases central nervous system-derived proteins in the cerebrospinal fluid
Autor:
Gina Jerome, Mary Beth Finn, David M. Holtzman, Jack H. Ladenson, Elizabeth M. Herries, Yo-El Ju, Daniel L. Crimmins, Anne M. Fagan, Courtney L. Sutphen
Publikováno v:
Annals of Neurology. 80:154-159
We hypothesized that one mechanism underlying the association between obstructive sleep apnea (OSA) and Alzheimer's disease is OSA leading to decreased slow wave activity (SWA), increased synaptic activity, decreased glymphatic clearance, and increas
Autor:
chao wang, Aimin Li, Rebecca Spellman, Xin Bao, Nathan Scott, Melissa Manis, Mary Beth Finn, Monica Xiong, Javier Remolina Serrano, Patrick Sullivan, David Holtzman
Publikováno v:
The Journal of Immunology. 204:64.6-64.6
ApoE4 is the strongest genetic risk factor for late-onset Alzheimer Disease. It has been reported that apoE isoforms directly affect tauopathy and tau-mediated neurodegeneration in P301S tau transgenic mice expressing different human apoE isoforms, w
Autor:
Joel C. Geerling, David M. Holtzman, John R. Cirrito, Brendan P. Lucey, Chanung Wang, Thomas E. Mahan, Mary Beth Finn, Jerrah K. Holth, Nigel P. Pedersen, Patrick M. Fuller, Melissa Manis, Sarah K. Fritschi
Publikováno v:
Science (New York, N.Y.), vol 363, iss 6429
Sleep may protect the brain from AD Two main proteins accumulate in the brain in Alzheimer's disease (AD), β-amyloid (Aβ) and tau. Aβ appears to instigate AD, but tau appears to drive brain damage and cognitive decline. Sleep deprivation is known