Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Mary Beth Young"'
Publikováno v:
Journal of Autism and Developmental Disorders. 42:1425-1434
Individuals high or low in self-reported social skill were recruited opportunistically. When presented with everyday social scenarios ending with an awkward request or offer, the high social skill participants more often used sophisticated strategies
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a5c2e114b52483e02c4fa7187f097be1
https://doi.org/10.1007/s10803-011-1381-z
https://doi.org/10.1007/s10803-011-1381-z
Publikováno v:
Tetrahedron Letters. 47:4827-4830
A convenient one pot method for the synthesis of 2,5-disubstituted 1,3,4-oxadiazoles from acids and acyl hydrazides is reported. Acid activation with CDI, followed by coupling with the desired acylhydrazide and dehydration in the same pot with Ph 3 P
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb076d38b777a4108855232af742379f
https://doi.org/10.1016/j.tetlet.2006.05.051
https://doi.org/10.1016/j.tetlet.2006.05.051
Publikováno v:
Tetrahedron Letters. 46:8909-8912
An asymmetric route to dihydroquinazolinones via the addition of ortho metalated substrates to tert-butanesulfinyl imines is reported. The scope of the nucleophile and electrophile components and the absolute stereochemical outcome are presented.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::575589955fee0fa420cd92398aa24b2f
https://doi.org/10.1016/j.tetlet.2005.10.067
https://doi.org/10.1016/j.tetlet.2005.10.067
Autor:
Ruth Z. Rutledge, April M. Cunningham, William F. Hoffman, Scott R. Hambaugh, Rosemary C. McFall, William R. Huckle, Richard L. Kendall, Hungate Randall W, Mark E. Fraley, Kathleen E. Coll, Kenneth A. Thomas, Mary Beth Young, Kenneth L. Arrington, Andrew J. Tebben
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2973-2976
We have discovered 3-(5-thien-3-ylpyridin-3-yl)-1H-indoles as potent inhibitors of KDR kinase activity. This communication details the evolution of this novel class from a potent screening lead of vastly different structure with an emphasis on struct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57438433558205e485fcd402837b6de2
https://doi.org/10.1016/s0960-894x(03)00627-9
https://doi.org/10.1016/s0960-894x(03)00627-9
Autor:
Philippe G. Nantermet, Harold G. Selnick, Youwei Yan, Bobby J. Lucas, Janetta M. Pellicore, Joseph P. Vacca, Julie A. Krueger, James C. Barrow, Christina L. Newton, S. Dale Lewis, Mary Beth Young, Lawrence C. Kuo, Daniel R. McMasters
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:2781-2784
A series of potent and selective proline- and pyrazinone-based macrocyclic thrombin inhibitors is described. Detailed SAR studies led to the incorporation of specific functional groups in the tether that enhanced functional activity against thrombin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f65a7a74a795c0575dc5998cddbcb3d
https://doi.org/10.1016/s0960-894x(03)00506-7
https://doi.org/10.1016/s0960-894x(03)00506-7
Autor:
Joel R. Huff, Mary Beth Young, Craig A. Coburn, Hungate Randall W, Richard C.A. Isaacs, Joseph P. Vacca
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:1937-1940
A series of analogs of CRIXIVAN® containing various aromatic P1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8d83cd30b47f5e4b6056a8b40ada973d
https://doi.org/10.1016/0960-894x(96)00345-9
https://doi.org/10.1016/0960-894x(96)00345-9
Autor:
Sarah Crawford, Mary-Beth Young, Shelley Channon, Helen Simmons, Jeremy S Stern, Helena Drury, Roxanne Barrett
Publikováno v:
Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence. 18(3)
Tourette's syndrome (TS) is predominantly a childhood disorder, with many of those who meet diagnostic criteria in childhood experiencing a remission of symptoms in adulthood. This indicates that the influence of TS on cognitive and emotional process
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1547755af7118c4062283a432052641b
https://pubmed.ncbi.nlm.nih.gov/21970723
https://pubmed.ncbi.nlm.nih.gov/21970723
Autor:
Jeremy S Stern, Mary-Beth Young, Andrea E. Cavanna, Mary M. Robertson, Michael Orth, Hugo D. Critchley
Background Recent studies using quantitative methods, such as principal component factor analysis, hierarchical cluster analysis and latent class analysis have suggested that Gilles de la Tourette syndrome (GTS) should no longer be considered a unita
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f54d0fb7741e6ca0a17e7bff9e21545c
https://hdl.handle.net/10281/413858
https://hdl.handle.net/10281/413858
Autor:
Hungate Randall W, Joel R. Huff, Craig A. Coburn, Joseph P. Vacca, Richard C.A. Isaacs, Mary Beth Young
Publikováno v:
ChemInform. 27
A series of analogs of CRIXIVAN® containing various aromatic P1 ligands were prepared and evaluated for inhibition of the HIV-1 protease enzyme. These new compounds were found to be effective inhibitors at nanomolar concentrations in the in vitro en
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::833fff175d92d944df42cca4317eda7e
https://doi.org/10.1002/chin.199652121
https://doi.org/10.1002/chin.199652121
Autor:
John T. Sisko, Kenneth D. Anderson, Meiquing Lu, Ming-Tain Lai, Theresa M. Williams, Vandna Munshi, Carolyn Bahnck, Yuexia Liang, Bang-Lin Wan, Gregory Moyer, Thomas J. Tucker, Michael W. Miller, Joe P. Vacca, Rebecca Perlow-Poehnelt, John Jin Lim, Daniel J. DiStefano, Rosa I. Sanchez, Peter J. Felock, Dai-Shi Su, Sinoeun Touch, Deanne Rudd, Elizabeth Tinney, Saggar Sandeep A, Neville J. Anthony, Mary Beth Young, Jessica A. Flynn
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(15)
Biaryl ethers were recently reported as potent NNRTIs. Herein, we disclose a detailed effort to modify the previously reported compound 1. We have designed and synthesized a series of novel pyrazole derivatives as a surrogate for pyrazolopyridine mot
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89e40ef12429f6bf81611e5225e4230e
https://pubmed.ncbi.nlm.nih.gov/20609585
https://pubmed.ncbi.nlm.nih.gov/20609585