Výsledky vyhledávání - "Mary B. O'Neill"

Akademický článek

Investigation of Genetic Susceptibility to Blastomycosis Reveals Interleukin-6 as a Potential Susceptibility Locus

Autor: Richard M. Merkhofer, Mary B. O’Neill, Donny Xiong, Nydiaris Hernandez-Santos, Hannah Dobson, J. Scott Fites, Abigail C. Shockey, Marcel Wuethrich, Caitlin S. Pepperell, Bruce S. Klein

Publikováno v: mBio, Vol 10, Iss 3 (2019)

ABSTRACT Genetic differences are hypothesized to underlie ethnic disparities in incidence rates of the endemic systemic mycoses, including blastomycosis. Individuals of Hmong ancestry display elevated risk for this serious fungal infection. Here, we

Externí odkaz: https://doaj.org/article/91eb12aeeb194bb5b05e852023c0da39

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Akademický článek

Adaptation in a Fibronectin Binding Autolysin of Staphylococcus saprophyticus

Autor: Tatum D. Mortimer, Douglas S. Annis, Mary B. O’Neill, Lindsey L. Bohr, Tracy M. Smith, Hendrik N. Poinar, Deane F. Mosher, Caitlin S. Pepperell

Publikováno v: mSphere, Vol 2, Iss 6 (2017)

ABSTRACT Human-pathogenic bacteria are found in a variety of niches, including free-living, zoonotic, and microbiome environments. Identifying bacterial adaptations that enable invasive disease is an important means of gaining insight into the molecu

Externí odkaz: https://doaj.org/article/91e797bf65b746edb92975a1a0a9391a

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Akademický článek

Providing Open-Access Know How for Directors of Quantitative and Mathematics Support Centers

Autor: Michael Schuckers, Mary B. O'Neill, Grace Coulombe

Publikováno v: Numeracy, Vol 10, Iss 1, p 2 (2017)

The purpose of this editorial is to introduce the quantitative literacy community to the newly published A Handbook for Directors of Quantitative and Mathematics Centers. QMaSCs (pronounced “Q-masks”) can be broadly defined as centers that have s

Externí odkaz: https://doaj.org/article/401d02f25cda4391a234c2a47a2a8e14

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Akademický článek

Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis

Autor: Tracy M Smith, Madison A Youngblom, John F Kernien, Mohamed A Mohamed, Sydney S Fry, Lindsey L Bohr, Tatum D Mortimer, Mary B O'Neill, Caitlin S Pepperell

Publikováno v: eLife, Vol 11 (2022)

Tuberculosis (TB), caused by Mycobacterium tuberculosis (M. tb), is a leading cause of death due to infectious disease. TB is not traditionally associated with biofilms, but M. tb biofilms are linked with drug and immune tolerance and there is increa

Externí odkaz: https://doaj.org/article/5fc89de44b6d43769f6e64d4c6e6a35a

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High-throughput droplet-based analysis of influenza A virus genetic reassortment by single-virus RNA sequencing

Autor: Kuang-Yu Chen, Jayaprakash Karuppusamy, Mary B. O’Neill, Vaitea Opuu, Mathieu Bahin, Sophie Foulon, Pablo Ibanez, Lluis Quintana-Murci, Tatsuhiko Ozawa, Sylvie van der Werf, Philippe Nghe, Nadia Naffakh, Andrew Griffiths, Catherine Isel

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Proceedings of the National Academy of Sciences of the United States of America, 2023, 120 (6), pp.e2211098120. ⟨10.1073/pnas.2211098120⟩

International audience; The segmented RNA genome of influenza A viruses (IAVs) enables viral evolution through genetic reassortment after multiple IAVs coinfect the same cell, leading to viruses harboring combinations of eight genomic segments from d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e1a6151b328050a32ee6cb40589637fd
https://doi.org/10.1073/pnas.2211098120

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Author response: Rapid adaptation of a complex trait during experimental evolution of Mycobacterium tuberculosis

Autor: Madison A Youngblom, Tracy M Smith, John F Kernien, Mohamed A Mohamed, Sydney S Fry, Lindsey L Bohr, Tatum D Mortimer, Mary B O'Neill, Caitlin S Pepperell

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1604c43a18637e7deed91b97db63b079
https://doi.org/10.7554/elife.78454.sa2

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Heterogeneity of monocyte subsets and susceptibility to influenza virus contribute to inter-population variability of protective immunity

Autor: Qian Zhang, Aurélie Bisiaux, Valentina Libri, Hélène Quach, Shen-Ying Zhang, Julien Pothlichet, Nadia Naffakh, Daniela Matuozzo, Laurent Abel, Milena Hasan, Yann Aquino, Nora Zidane, Mary B. O’Neill, Matthieu Deschamps, Jean-Laurent Casanova, Aurélie Cobat, Maxime Rotival, Lluis Quintana-Murci

There is considerable inter-individual and inter-population variability in response to viruses. The potential of monocytes to elicit type-I interferon responses has attracted attention to their role in viral infections. Here, we use an ex vivo model

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4b1f290fcedb35f931c0de313b2f5a79
https://doi.org/10.1101/2020.12.07.414151

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Genetic susceptibility to severe childhood asthma and rhinovirus-C maintained by balancing selection in humans for 150 000 years

Autor: João C. Teixeira, Mary B. O’Neill, Caitlin S. Pepperell, Ann C. Palmenberg, Guillaume Laval

Publikováno v: Hum Mol Genet
Human Molecular Genetics
Human Molecular Genetics, Oxford University Press (OUP), 2020, 29 (5), pp.736-744. ⟨10.1093/hmg/ddz304⟩
Human Molecular Genetics, 2020, 29 (5), pp.736-744. ⟨10.1093/hmg/ddz304⟩

Selective pressures imposed by pathogens have varied among human populations throughout their evolution, leading to marked inter-population differences at some genes mediating susceptibility to infectious and immune-related diseases. Here, we investi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af99a4c345338594a98a2af69a637868
https://pubmed.ncbi.nlm.nih.gov/31841129

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