Zobrazeno 1 - 10
of 326
pro vyhledávání: '"Mary B, Goldring"'
Autor:
Olufunmilayo O. Ayobami, Steven R. Goldring, Mary B. Goldring, Timothy M. Wright, Marjolein C.H. van der Meulen
Publikováno v:
Bone Reports, Vol 17, Iss , Pp 101602- (2022)
Objective: Clinical evidence suggests that abnormal mechanical forces play a major role in the initiation and progression of osteoarthritis (OA). However, few studies have examined the mechanical environment that leads to disease. Thus, using a mouse
Externí odkaz:
https://doaj.org/article/27646bf340d04d6e89d8c7b24b0436fa
Autor:
Purva Singh, Mengying Wang, Piali Mukherjee, Samantha G. Lessard, Tania Pannellini, Camila B. Carballo, Scott A. Rodeo, Mary B. Goldring, Miguel Otero
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
Abstract In osteoarthritis (OA), articular chondrocytes display phenotypic and functional changes associated with epigenomic alterations. These changes contribute to the disease progression, which is characterized by dysregulated reparative processes
Externí odkaz:
https://doaj.org/article/007f070d6a774253b64601a71b7991cf
Autor:
Giovanni Trisolino, Marta Favero, Dante Dallari, Enrico Tassinari, Francesco Traina, Miguel Otero, Steven R. Goldring, Mary B. Goldring, Chiara Carubbi, Roberta Ramonda, Stefano Stilli, Brunella Grigolo, Eleonora Olivotto
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 15, Iss 1, Pp 1-9 (2020)
Abstract Background Hip osteoarthritis (HOA) is the most common hip disorder and a major cause of disability in the adult population, with an estimated prevalence of end-stage disease and total hip replacement. Thus, the diagnosis, prevention, and tr
Externí odkaz:
https://doaj.org/article/1007d16b16f247279b99ef0eca5610db
Autor:
Eleonora Olivotto, Elisa Belluzzi, Assunta Pozzuoli, Augusto Cigolotti, Manuela Scioni, Steven R. Goldring, Mary B. Goldring, Pietro Ruggieri, Roberta Ramonda, Brunella Grigolo, Giovanni Trisolino, Marta Favero
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 7, p 3903 (2022)
The menisci exert a prominent role in joint stabilization and in the distribution of mechanical loading. Meniscal damage is associated with increased risk of knee OA. The aim of this study was to characterize the synovial membrane and meniscal tissue
Externí odkaz:
https://doaj.org/article/52a2d7e8244f4cb0b87e69b204a719e0
Autor:
Javier Conde, Miguel Otero, Morena Scotece, Vanessa Abella, Rodolfo Gómez, Verónica López, Jesús Pino, Antonio Mera, Mary B. Goldring, Oreste Gualillo
Publikováno v:
Cellular Physiology and Biochemistry, Vol 45, Iss 6, Pp 2401-2410 (2018)
Background/Aims: The E74-like factor 3 (ELF3) is an inflammatory mediator that participates in cartilage destruction in osteoarthritis. Leptin and other adipokines negatively impact articular cartilage, triggering catabolic and inflammatory responses
Externí odkaz:
https://doaj.org/article/fb4aa18d6348436bb7b55a04b95843b5
Autor:
Atsushi Takahashi, María C. de Andrés, Ko Hashimoto, Eiji Itoi, Miguel Otero, Mary B. Goldring, Richard O. C. Oreffo
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The Runt-related transcription factor 2 (RUNX2) is critical for bone formation as well as chondrocyte maturation. Matrix metalloproteinase (MMP)-13 is a major contributor to cartilage degradation in osteoarthritis (OA). We and others have sh
Externí odkaz:
https://doaj.org/article/cd76ae98337946548bf91121591784a3
Autor:
Weam Alshenibr, Mustafa M. Tashkandi, Saqer F. Alsaqer, Yazeed Alkheriji, Amelia Wise, Sadanand Fulzele, Pushkar Mehra, Mary B. Goldring, Louis C. Gerstenfeld, Manish V. Bais
Publikováno v:
Arthritis Research & Therapy, Vol 19, Iss 1, Pp 1-15 (2017)
Abstract Background Lysyl oxidase like-2 (LOXL2) is a copper-dependent amine oxidase. Our previous studies showed that LOXL2 is elevated during mouse fracture healing. The goal of this study was to evaluate the potential of LOXL2 to act as an anaboli
Externí odkaz:
https://doaj.org/article/06803ddf1f124c34beddad45be728b08
Autor:
Yang Lei, Zhao Guanghui, Wang Xi, Wang Yingting, Lin Xialu, Yu Fangfang, Mary B. Goldring, Guo Xiong, Mikko J. Lammi
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)
Abstract The relationship between T-2 toxin and deoxynivalenol (DON) and the risk of Kashin-Beck disease is still controversial since it is poorly known about their selectivity in cartilage damage. We aimed to compare the cytotoxicity of T-2 toxin an
Externí odkaz:
https://doaj.org/article/0aff6a293be84ac8831c3ff209026894
Autor:
Giovanni Trisolino, Marta Favero, Dante Dallari, Enrico Tassinari, Francesco Traina, Miguel Otero, Steven R. Goldring, Mary B. Goldring, Chiara Carubbi, Roberta Ramonda, Stefano Stilli, Brunella Grigolo, Eleonora Olivotto
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 15, Iss 1, Pp 1-2 (2020)
Externí odkaz:
https://doaj.org/article/4ae2c2383c014fe5a0fc43dfc96019ae
Autor:
Michela Battistelli, Marta Favero, Debora Burini, Giovanni Trisolino, Dante Dallari, Lucia De Franceschi, Steven R. Goldring, Mary B. Goldring, Elisa Belluzzi, Giuseppe Filardo, Brunella Grigolo, Elisabetta Falcieri, Eleonora Olivotto
Publikováno v:
European Journal of Histochemistry, Vol 63, Iss 1 (2019)
The human meniscus plays a crucial role for transmission and distribution of load across the knee, as well as shock absorption, joint stability, lubrication, and congruity. The aim of this study was to compare the complex geometry, and unique ultrast
Externí odkaz:
https://doaj.org/article/a52eeca1f51d458d9aa2521b9ca64acf