Zobrazeno 1 - 10
of 51
pro vyhledávání: '"Mary Anna Carbone"'
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Huang et al. show that developing under different temperatures changes the genetic architecture of regulatory variation in Drosophila melanogaster gene expression yet the co-expression network remains robust. Data suggest that stabilizing selection o
Externí odkaz:
https://doaj.org/article/6a61c4dc8259471cb7b8dcfc716eb7c7
Autor:
Wen Huang, Terry Campbell, Mary Anna Carbone, W Elizabeth Jones, Desiree Unselt, Robert R H Anholt, Trudy F C Mackay
Publikováno v:
PLoS Biology, Vol 18, Iss 3, p e3000645 (2020)
Understanding the genetic basis of variation in life span is a major challenge that is difficult to address in human populations. Evolutionary theory predicts that alleles affecting natural variation in life span will have properties that enable them
Externí odkaz:
https://doaj.org/article/b23b6afa757842ea9088617d7dc048c5
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-8 (2017)
Abstract Longevity varies among individuals, but how natural genetic variation contributes to variation in lifespan is poorly understood. Drosophila melanogaster presents an advantageous model system to explore the genetic underpinnings of longevity,
Externí odkaz:
https://doaj.org/article/52e9ddcee5544de9abae501bc3332df7
Autor:
Wen Huang, Richard F Lyman, Rachel A Lyman, Mary Anna Carbone, Susan T Harbison, Michael M Magwire, Trudy FC Mackay
Publikováno v:
eLife, Vol 5 (2016)
Externí odkaz:
https://doaj.org/article/d0f0f5320eea4f09932fcac04f28bf8e
Autor:
Wen Huang, Richard F Lyman, Rachel A Lyman, Mary Anna Carbone, Susan T Harbison, Michael M Magwire, Trudy FC Mackay
Publikováno v:
eLife, Vol 5 (2016)
Mutation and natural selection shape the genetic variation in natural populations. Here, we directly estimated the spontaneous mutation rate by sequencing new Drosophila mutation accumulation lines maintained with minimal natural selection. We inferr
Externí odkaz:
https://doaj.org/article/beee1b02c57b454791f8d7e7594ea44b
Autor:
John R Shorter, Matthew Geisz, Ergi Özsoy, Michael M Magwire, Mary Anna Carbone, Trudy F C Mackay
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0134612 (2015)
Royal Jelly (RJ) is a product made by honey bee workers and is required for queen differentiation and accompanying changes in queen body size, development time, lifespan and reproductive output relative to workers. Previous studies have reported simi
Externí odkaz:
https://doaj.org/article/7edef4b7f5a44d9cb925807c349f96cc
Autor:
Megan Ulmer Carnes, Terry Campbell, Wen Huang, Daniel G Butler, Mary Anna Carbone, Laura H Duncan, Sasha V Harbajan, Edward M King, Kara R Peterson, Alexander Weitzel, Shanshan Zhou, Trudy F C Mackay
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0138569 (2015)
Natural populations harbor considerable genetic variation for lifespan. While evolutionary theory provides general explanations for the existence of this variation, our knowledge of the genes harboring naturally occurring polymorphisms affecting life
Externí odkaz:
https://doaj.org/article/36bb4da953e449adb4ef2286161087cd
Autor:
Mary Anna Carbone, Yuhong Chen, Guy A Hughes, Robert N Weinreb, Norman A Zabriskie, Kang Zhang, Robert R H Anholt
Publikováno v:
PLoS ONE, Vol 6, Iss 5, p e20649 (2011)
The statistical power of genome-wide association (GWA) studies to detect risk alleles for human diseases is limited by the unfavorable ratio of SNPs to study subjects. This multiple testing problem can be surmounted with very large population sizes w
Externí odkaz:
https://doaj.org/article/8b41c5692e0a4917a1c68b46346be452
Autor:
Michael M Magwire, Akihiko Yamamoto, Mary Anna Carbone, Natalia V Roshina, Alexander V Symonenko, Elena G Pasyukova, Tatiana V Morozova, Trudy F C Mackay
Publikováno v:
PLoS Genetics, Vol 6, Iss 7, p e1001037 (2010)
Understanding the genetic and environmental factors that affect variation in life span and senescence is of major interest for human health and evolutionary biology. Multiple mechanisms affect longevity, many of which are conserved across species, bu
Externí odkaz:
https://doaj.org/article/b791a2498b27498eba850b861e7cffe7
Autor:
Mary Anna Carbone, Julien F Ayroles, Akihiko Yamamoto, Tatiana V Morozova, Steven A West, Michael M Magwire, Trudy F C Mackay, Robert R H Anholt
Publikováno v:
PLoS ONE, Vol 4, Iss 1, p e4216 (2009)
Glaucoma is the world's second leading cause of bilateral blindness with progressive loss of vision due to retinal ganglion cell death. Myocilin has been associated with congenital glaucoma and 2-4% of primary open angle glaucoma (POAG) cases, but th
Externí odkaz:
https://doaj.org/article/d3e0cb21ecd74cbfa320e04f2083bc0e