Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Mary Ann Mallon"'
Autor:
Matthew A. Powell, Tim Hui-Ming Huang, Pearlly S. Yan, David G. Mutch, Mary Ann Mallon, Ken C. Walls, Amy P. Schmidt, Paul J. Goodfellow, Israel Zighelboim
Purpose: To identify novel endometrial cancer-specific methylation markers and to determine their association with clinicopathologic variables and survival outcomes.Experimental Design: Differential methylation hybridization analysis (DMH) was done f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d68d776bd0effffe69a9aae67d3e599
https://doi.org/10.1158/1078-0432.c.6518314.v1
https://doi.org/10.1158/1078-0432.c.6518314.v1
Autor:
Paul J. Goodfellow, Jack B. Keenan, Pamela M. Pollock, Candice L. Wellens, Matthew A. Powell, Michael Gartside, Mary Ann Mallon, Sara A. Byron
Publikováno v:
Cancer Research. 68:6902-6907
KRAS activation and PTEN inactivation are frequent events in endometrial tumorigenesis, occurring in 10% to 30% and 26% to 80% of endometrial cancers, respectively. Because we have recently shown activating mutations in fibroblast growth factor recep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eebbce0eb9cd80c121626113bb10d88e
https://doi.org/10.1158/0008-5472.can-08-0770
https://doi.org/10.1158/0008-5472.can-08-0770
Autor:
Mary Ann Mallon, Helen Davies, L. Dejeza, Phillip Andrew Futreal, Pamela M. Pollock, Jeffrey M. Trent, Paul J. Goodfellow, Matthew A. Powell, Michael Gartside, Michael R. Stratton, Moosa Mohammadi
Publikováno v:
Oncogene. 26:7158-7162
Endometrial carcinoma is the most common gynecological malignancy in the United States. Although most women present with early disease confined to the uterus, the majority of persistent or recurrent tumors are refractory to current chemotherapies. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b28dd11b3ee1f533fd8de5a68230106d
https://doi.org/10.1038/sj.onc.1210529
https://doi.org/10.1038/sj.onc.1210529
Autor:
Amy P. Schmidt, Ken C. Walls, David G. Mutch, Israel Zighelboim, Matthew A. Powell, Mary Ann Mallon, Pearlly S. Yan, Tim H M Huang, Paul J. Goodfellow
Publikováno v:
Clinical Cancer Research. 13:2882-2889
Purpose: To identify novel endometrial cancer-specific methylation markers and to determine their association with clinicopathologic variables and survival outcomes.Experimental Design: Differential methylation hybridization analysis (DMH) was done f
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efd23a3b5599ccec09a91a1c603d27f0
https://doi.org/10.1158/1078-0432.ccr-06-2367
https://doi.org/10.1158/1078-0432.ccr-06-2367
Publikováno v:
Pharmacogenomics. 6:873-877
Introduction: Most cancer pharmacogenetic studies use germline DNA, as tumor tissue is often inaccessible in the advanced disease setting. However, this relies on the assumption that germline DNA is representative of the tumor genotype. To date, ther
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b846b45488913914d7cecdef30b401c1
https://doi.org/10.2217/14622416.6.8.873
https://doi.org/10.2217/14622416.6.8.873
Publikováno v:
American Journal of Obstetrics and Gynecology. 190:935-939
Objective Defective DNA mismatch repair is a common genetic abnormality in both colon cancers and endometrial cancers. Cancers with defective DNA mismatch repair have the so-called mutator phenotype and accumulate genetic errors at an increased rate.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5279ec44e39b92df8495989ec06c842d
https://doi.org/10.1016/j.ajog.2004.01.017
https://doi.org/10.1016/j.ajog.2004.01.017
Publikováno v:
Biology of Reproduction. 57:1285-1292
The mechanism of labor initiation in humans has not been completely elucidated. Prostaglandins, estrogens, and corticotropin-releasing factor (CRF) have all been shown to affect uterine myocytes and enhance uterine contractility. There are also indic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::61897585093a823212032b2ea79a8f56
https://doi.org/10.1095/biolreprod57.6.1285
https://doi.org/10.1095/biolreprod57.6.1285
Autor:
Paul J. Goodfellow, Mary Ann Mallon, Wanghai Zhang, Robert R. Freimuth, Sharon Marsh, Howard L. McLeod, Mark A. Watson, Jinsheng Yu
Publikováno v:
Clinical cancer research : an official journal of the American Association for Cancer Research. 12(17)
Background: The ability to maintain DNA integrity is a critical cellular function. DNA repair is conducted by distinct pathways of genes, many of which are thought to be altered in colorectal cancer. However, there has been little characterization of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd59f3e6c8a2e3af95669bdaeeeedea
https://pubmed.ncbi.nlm.nih.gov/16951227
https://pubmed.ncbi.nlm.nih.gov/16951227
Publikováno v:
International journal of cancer. 119(8)
Exposure to unopposed estrogen is a potent risk factor for developing human endometrial cancer. However, little is known about the transcriptional changes elicited by estrogens in endometrial carcinogenesis, in part, because of genetic and environmen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26291114b3cfc32966dfa53ef95224ba
https://pubmed.ncbi.nlm.nih.gov/16804899
https://pubmed.ncbi.nlm.nih.gov/16804899
Autor:
Paul J. Goodfellow, John D. Pfeifer, Omar Kabbarah, Darryl Shibata, David H. Gutmann, Erin L. Winkeler, Mary Ann Mallon, Andrea Kathleen Sotelo, Ming‐Yu Fan
Publikováno v:
International journal of cancer. 115(4)
Inherited defects in DNA mismatch repair (MMR) predispose to a variety of malignancies in humans and in mouse knockout models. In humans, hemizygosity for one of several DNA MMR genes greatly increases an individual's risk for colon and endometrial c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::706cd70feab8c3a96ddec7ce25aff75c
https://pubmed.ncbi.nlm.nih.gov/15700306
https://pubmed.ncbi.nlm.nih.gov/15700306