Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Mary Alice Hefford"'
Autor:
Dae Young Kim, Rebecca To, Henk van Faassen, Joseph D. Schrag, Jamshid Tanha, Mary Alice Hefford, Wen Ding, Roger Mackenzie, Nadereh St-Amant, Yan Luo, John F. Kelly, Tomoko Hirama, Hiba Kandalaft
Publikováno v:
mAbs
We set out to gain deeper insight into the potential of antibody light chain variable domains (VLs) as immunotherapeutics. To this end, we generated a naïve human VL phage display library and, by using a method previously shown to select for non-agg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79ac06ab5ef9d4d96287a83a87816986
https://doi.org/10.4161/mabs.26844
https://doi.org/10.4161/mabs.26844
Publikováno v:
Journal of Pharmaceutical Sciences. 101:3672-3686
Standard pharmacopeial test methods for biologics broadly focus on identity (active substance and impurities) and function (activity and toxicity). However, it is less clear which, if any, of the methods can identify a subtle change in protein therap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a8a5da84bdb3c9f5f2f5418e046eff5
https://doi.org/10.1002/jps.23276
https://doi.org/10.1002/jps.23276
Publikováno v:
World Journal of Vaccines. :125-142
Avian influenza, subtype H5N1, causes occasional but serious infections in humans and efforts to produce vaccines against this strain continue. Current influenza vaccines are prophylactic and utilize the two major antigens, hemagglutinin and neuramin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::312a017ecbda768ba575c43ff8fb27cd
https://doi.org/10.4236/wjv.2012.23017
https://doi.org/10.4236/wjv.2012.23017
Autor:
Mary Alice Hefford, Mike Cauchy
Publikováno v:
Biologicals. 38:637-643
Demonstrations of bio-similarity between subsequent entry (follow-on) biologics and innovator's formulated drug products may depend upon methods that either remove excipients completely or allow the exchange of excipients to give equivalent formulati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::be366112554c62bea14d785e0497d935
https://doi.org/10.1016/j.biologicals.2010.07.005
https://doi.org/10.1016/j.biologicals.2010.07.005
Autor:
Virginia García-Cañas, Barry Lorbetskie, Mary Alice Hefford, Michel Girard, Terry D. Cyr, Sophie Smith
Publikováno v:
Biologicals. 38:294-302
A combination of separation and identification techniques was used to rapidly and reproducibly analyze influenza vaccine constituents. Size-exclusion HPLC analysis reduced significantly the complexity by providing a constituents profile according to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8764393fe2ebfa5daeccf5a705583642
https://doi.org/10.1016/j.biologicals.2009.12.005
https://doi.org/10.1016/j.biologicals.2009.12.005
Publikováno v:
Biologicals. 38:314-320
Many therapeutic biologics are formulated with excipients, including the protein excipient human serum albumin (HSA), to increase stability and prevent protein aggregation and adsorption onto glass vials. One biologic formulated with albumin is inter
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::32a2500ea3c70a63281ecef69f39652f
https://doi.org/10.1016/j.biologicals.2009.11.010
https://doi.org/10.1016/j.biologicals.2009.11.010
Autor:
M.L. Kalmokoff, Terry D. Cyr, John W. Austin, L. B. Selinger, Ronald M. Teather, Mary Alice Hefford
Publikováno v:
Anaerobe. 15:74-81
Thin sectioning and freeze-fracture-etch of the ovine ruminal isolate Mitsuokella multacida strain 46/5(2) revealed a Gram-negative envelope ultra-structure consisting of a peptidoglycan wall overlaid by an outer membrane. Sodium-dodecyl-sulfate-poly
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4fe467d331f135b8b1926751c6ab9c8
https://doi.org/10.1016/j.anaerobe.2009.01.001
https://doi.org/10.1016/j.anaerobe.2009.01.001
Autor:
Mary Alice Hefford, Xuguang Li, John K. Mark, Bozena Jaentschke, Sylvie M. Fournier, Terry D. Cyr
Publikováno v:
Biochemical and Biophysical Research Communications
The severe acute respiratory syndrome (SARS) is a contagious disease that killed hundreds and sickened thousands of people worldwide between November 2002 and July 2003. The nucleocapsid (N) protein of the coronavirus responsible for this disease pla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3cb085f388ef3538d2655e51b81fef8
https://doi.org/10.1016/j.bbrc.2008.09.153
https://doi.org/10.1016/j.bbrc.2008.09.153
Publikováno v:
Biotechnology and Bioengineering. 101:452-459
A novel glycation procedure, in vacuo glycation, was used to attach glucose covalently to the lysine residues of trypsin and chymotrypsin. Glycated trypsin and glycated chymotrypsin have greatly increased thermostability compared to the native enzyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8ebf5c2b53bc53c8a9a632efaec6ce91
https://doi.org/10.1002/bit.21919
https://doi.org/10.1002/bit.21919
Publikováno v:
Journal of Biological Chemistry. 283:28574-28583
Mitogen-activated protein (MAP) kinase phosphatase 3 (MKP3) is a cytoplasmic dual specificity phosphatase that functions to attenuate signaling via dephosphorylation and subsequent deactivation of its substrate and allosteric regulator, extracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b46840c5917c6bd92cbb1baa65ed2b3
https://doi.org/10.1074/jbc.m801747200
https://doi.org/10.1074/jbc.m801747200