Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mary Alejandro"'
Autor:
Shaila K. Mani, Barry M. Markaverich, Jan R. Crowley, John Turk, Andrea Reyna, Trellis Thompson, John T. Sharp, Mary Alejandro, Wendy Portillo
Publikováno v:
Environmental Health Perspectives
Reports from our laboratory and others have described adverse effects of corncob bedding on reproductive function in rats and mice (Markaverich et al. 2002b; Port and Kaltenbach 1969). For this reason, we recently identified one class of biological a
Publikováno v:
Steroids. 70:750-754
The mitogenic agent that disrupts male and female sexual behavior has been isolated from corncob bedding. The disrupting activity resides in an isomeric mixture of linoleic acid derivatives with a tetrahydrofuran ring and two hydroxyl groups (THF-dio
Autor:
Andrea Reyna, Barry M. Markaverich, Mary Alejandro, Nancy Casajuna, John T. Sharp, Jan R. Crowley, Shaila K. Mani, Kevin Shoulars
Publikováno v:
Environmental Health Perspectives
Previous studies in our laboratory demonstrated that high-performance liquid chromatography (HPLC) analysis of ground corncob bedding extracts characterized two components (peak I and peak II) that disrupted endocrine function in male and female rats
Publikováno v:
Biochemical and Biophysical Research Communications. 296:1083-1090
[3H]Luteolin binds covalently to uterine nuclear type II sites [B. Markaverich, K. Shoulars, M.A. Alejandro, T. Brown, Steroids 66 (2001) 707] and was used to identify this protein(s). SDS–PAGE analyses of [3H]luteolin-labeled type II site preparat
Autor:
John Turk, Jan R. Crowley, David Markaverich, Barry M. Markaverich, Lois Zitzow, Nancy Casajuna, Nathan Camarao, Robert E. Faith, Mary Alejandro, Jamal Hill, Ken Bhirdo
Publikováno v:
Biochemical and Biophysical Research Communications. 291:692-700
A mitogenic agent in corncob bedding and fresh corn products disrupts sexual behavior and estrous cyclicity in rats. The mitogenic activity resides in an isomeric mixture of linoleic acid derivatives with a tetrahydrofuran ring and two hydroxyl group
Autor:
Robert E. Faith, Andrea Mitchell, Chris Murchison, Mary Alejandro, Barry M. Markaverich, Shaila K. Mani, Trellis Brown, Claudia Velez-Trippe, Bert W. O'Malley, David Markaverich
Publikováno v:
Environmental Health Perspectives. 110:169-177
Housing adult rats on ground corncob bedding impedes male and female mating behavior and causes acyclicity in females. The suppressive effects on ovarian cyclicity are mimicked by a mitogenic agent purified from the ground corncob bedding material (c
Purification and characterization of nuclear type II [3H]estradiol binding sites from the rat uterus
Publikováno v:
Steroids. 66:707-719
Type II [3H]estradiol binding sites play an important role in normal and malignant cell growth and proliferation and the delineation of the precise function of the type II site in cell growth has been hampered by the inability to purify, sequence and
Publikováno v:
Journal of Steroid Biochemistry. 28:599-608
Previous studies from our laboratory demonstrated that normal, but not malignant tissues, contain a ligand which competes for [3H]estradiol binding to nuclear type II sites in the rat uterus. Since elevated nuclear levels of type II sites are correla
Publikováno v:
Journal of Biological Chemistry. 261:142-146
A recent report by Lyttle et al. (Lyttle, C. R., Medlock, R. L., and Sheehan, D. M. (1984) J. Biol. Chem. 259, 2697-2700) suggested that nuclear type II sites in the rat uterus are of eosinophil origin and may represent [3H]estradiol binding to eosin
Publikováno v:
Biochemical and Biophysical Research Communications. 165:391-400
Dopamine interaction with target cells undoubtably involves binding to plasma membrane receptors. However, the well documented cell growth inhibitory activity of this catecholamine suggests nuclear regulation. To evaluate this possibility, we determi