Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Mary A. Piotrowski"'
Autor:
Zachary Lee Johnson, Mark Ammirati, David Jonathan Wasilko, Jeanne S. Chang, Stephen Noell, Timothy L. Foley, Hyejin Yoon, Kathleen Smith, Shoh Asano, Katherine Hales, Min Wan, Qingyi Yang, Mary A. Piotrowski, Kathleen A. Farley, Tamara Gilbert, Lisa M. Aschenbrenner, Kimberly F. Fennell, Jason K. Dutra, Mary Xu, Chunyang Guo, Alison E. Varghese, Justin Bellenger, Alandra Quinn, Christopher W. am Ende, Graham M. West, Matthew C. Griffor, Donald Bennett, Matthew Calabrese, Claire M. Steppan, Seungil Han, Huixian Wu
Publikováno v:
Nature Structural & Molecular Biology. 30:22-30
Glycerol-3-phosphate acyltransferase (GPAT)1 is a mitochondrial outer membrane protein that catalyzes the first step of de novo glycerolipid biosynthesis. Hepatic expression of GPAT1 is linked to liver fat accumulation and the severity of nonalcoholi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40abbd054f7e4f0b7d37c1f6aa452bc0
https://doi.org/10.1038/s41594-022-00884-7
https://doi.org/10.1038/s41594-022-00884-7
Autor:
Douglas K. Spracklin, Karl E.G. Richter, Barbara Tate, Michael J. Karmilowicz, Tracy M. Brown, Lit-Fui Lau, Mary A. Piotrowski, David D. Auperin, Ping Du, Thomas A. Lanz, Nikolay Pozdnyakov, Charles E. Nolan, Charles F. Ebbinghaus, Kathleen M. Wood, James E. Finley, Kieran F. Geoghegan, Joel B. Schachter, Qing Fei, Yuhpyng L. Chen
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 319(2)
LY-450139 is a gamma-secretase inhibitor shown to have efficacy in multiple cellular and animal models. Paradoxically, robust elevations of plasma amyloid-beta (Abeta) have been reported in dogs and humans after administration of subefficacious doses
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6c0ad0c68a311c0b0af82803eabb8ddd
https://pubmed.ncbi.nlm.nih.gov/16920992
https://pubmed.ncbi.nlm.nih.gov/16920992
Autor:
Allen J. Duplantier, Stacey L. Becker, Michael J. Bohanon, Kris A. Borzilleri, Boris A. Chrunyk, James T. Downs, Lain-Yen Hu, Ayman El-Kattan, Larry C. James, Shenping Liu, Jiemin Lu, Noha Maklad, Mahmoud N. Mansour, Scot Mente, Mary A. Piotrowski, Subas M. Sakya, Susan Sheehan, Stefanus J. Steyn, Christine A. Strick, Victoria A. Williams
Publikováno v:
Journal of Medicinal Chemistry; Jun2009, Vol. 52 Issue 11, p3576-3585, 10p