Výsledky vyhledávání - "Mary A. Logan"

Akademický článek

Axon degeneration induces glial responses through Draper-TRAF4-JNK signalling

Autor: Tsai-Yi Lu, Jennifer M. MacDonald, Lukas J. Neukomm, Amy E. Sheehan, Rachel Bradshaw, Mary A. Logan, Marc R. Freeman

Publikováno v: Nature Communications, Vol 8, Iss 1, Pp 1-9 (2017)

The engulfment receptor Draper is known to promote glial activation and phagocytosis of debris upon axonal injury. Luet al. identify TNF receptor associated factor 4 (TRAF4) as a binding partner of Draper, and map out the signalling cascade leading t

Externí odkaz: https://doaj.org/article/a0803d1cf18d4b59932815bc571bcf90

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Akademický článek

Delayed glial clearance of degenerating axons in aged Drosophila is due to reduced PI3K/Draper activity

Autor: Maria D. Purice, Sean D. Speese, Mary A. Logan

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)

Glial engulfment declines with age, but the mechanism is unclear. Here authors show that in the Drosophilaolfactory system, glial phagocytosis of injury-induced degenerating axons decreases with age due to reduced PI3K/Draper activity, and restoring

Externí odkaz: https://doaj.org/article/f6b672af42684873a638cdf9f9fd3158

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Akademický článek

Insulin-like Signaling Promotes Glial Phagocytic Clearance of Degenerating Axons through Regulation of Draper

Autor: Derek T. Musashe, Maria D. Purice, Sean D. Speese, Johnna Doherty, Mary A. Logan

Publikováno v: Cell Reports, Vol 16, Iss 7, Pp 1838-1850 (2016)

Neuronal injury triggers robust responses from glial cells, including altered gene expression and enhanced phagocytic activity to ensure prompt removal of damaged neurons. The molecular underpinnings of glial responses to trauma remain unclear. Here,

Externí odkaz: https://doaj.org/article/492ffcd9543b4dcf981ed3a5f045cd2c

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