Výsledky vyhledávání - "Mary A. Katofiasc"

Colorectal and bladder prokinetic activity of [Lys5, MeLeu9, Nle10]-NKA(4–10) after intranasal or sublingual delivery in dogs

Autor: Nadia M.J. Rupniak, Mary A. Katofiasc, Jungeun Bae, Karl B. Thor, Lesley Marson

Publikováno v: Canadian Journal of Physiology and Pharmacology. 101:171-179

The feasibility of eliciting defecation and urination after intranasal (IN) or sublingual (SL) delivery of a small peptide NK2 receptor agonist, [Lys5, MeLeu9, Nle10]-NKA(4–10), was examined using prototype formulations in dogs. In anesthetized ani

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4982a622407f86d4619cc1de523aff06
https://doi.org/10.1139/cjpp-2022-0498

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Chronic, Twice-Daily Dosing of an NK2 Receptor Agonist [Lys(5),MeLeu(9),Nle(10)]-NKA(4-10), Produces Consistent Drug-Induced Micturition and Defecation in Chronic Spinal Rats

Autor: Karl B. Thor, Lesley Marson, Carol M. Bobbitt, Raymond Keast Piatt, Mary A. Katofiasc

Publikováno v: J Neurotrauma

Acute administration of [Lys5,Me,Leu9,Nle10]-NKA(4-10) (LMN-NKA) produces contractions of the detrusor and rectum with voiding in intact and acutely spinal cord injured (SCI) rats. In the current study, the ability of LMN-NKA (10 μg/kg or 100 μg/kg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b624531955c535c2e072c1fa03c76f84
https://europepmc.org/articles/PMC7071061/

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Colorectal and cardiovascular effects of [Lys5,MeLeu9,Nle10]-NKA(4-10) in anesthetized macaques

Autor: Nadia M.J. Rupniak, Karl B. Thor, Edward C. Burgard, Mary A. Katofiasc

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 391:907-914

The effects of the tachykinin NK2 receptor agonist LMN-NKA ([Lys5,MeLeu9,Nle10]-NKA(4-10)) on colorectal and arterial blood pressure were examined in anesthetized macaques. Intravenous (IV) administration of 1–100 μg/kg caused dose-related increas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7236e2cf8f0393b7f5ca84d2e699fb80
https://doi.org/10.1007/s00210-018-1520-6

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[Lys5,MeLeu9,Nle10]-NKA(4–10) Elicits NK2 Receptor–Mediated Micturition and Defecation, and NK1 Receptor–Mediated Emesis and Hypotension, in Conscious Dogs

Autor: Mary A. Katofiasc, Alexander Walz, Karl B. Thor, Edward C. Burgard, Nadia M.J. Rupniak

Publikováno v: Journal of Pharmacology and Experimental Therapeutics. 366:136-144

Tachykinin neurokinin 2 (NK2) receptor agonists may have potential to alleviate clinical conditions associated with bladder and gastrointestinal underactivity by stimulating contraction of visceral smooth muscle. The ability of [Lys5,MeLeu9,Nle10]-ne

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a5939a6f239c83cb851441f1fff86245
https://doi.org/10.1124/jpet.118.248765

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Prokinetic effects of the neurokinin NK2 receptor agonist [Lys

Autor: Nadia M J, Rupniak, Mary A, Katofiasc, Lesley, Marson, Daniel J, Ricca, Karl B, Thor, Edward C, Burgard

Publikováno v: Neuropeptides

The effects of the neurokinin NK2 receptor agonist [Lys(5),MeLeu(9),Nle(10)]-NKA((4–10)) (LMN-NKA) on bladder and colorectal function were examined in minipigs. In anesthetized animals, subcutaneous (SC) administration of 30–100 μg/kg increased

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7b897c5db83d46141b876697b408332e
https://pubmed.ncbi.nlm.nih.gov/31324387

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Pharmacodynamic evaluation of Lys5, MeLeu9, Nle10-NKA(4–10) prokinetic effects on bladder and colon activity in acute spinal cord transected and spinally intact rats

Autor: Karl B. Thor, F. Aura Kullmann, Mary A. Katofiasc, Lesley Marson

Publikováno v: Naunyn-Schmiedeberg's Archives of Pharmacology. 390:163-173

The purpose of this study was to determine feasibility of a novel therapeutic approach to drug-induced voiding after spinal cord injury (SCI) using a well-characterized, peptide, neurokinin 2 receptor (NK2 receptor) agonist, Lys5, MeLeu9, Nle10-NKA(4

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::3dc7fa63b876322d0a6645ddd006545f
https://doi.org/10.1007/s00210-016-1317-4

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Prokinetic effects of neurokinin-2 receptor agonists on the bladder and rectum of rats with acute spinal cord transection

Autor: Edward C. Burgard, Lesley Marson, Karl B. Thor, Mary A. Katofiasc, Nadia M.J. Rupniak

The suitability of various neurokinin-2 (NK2) receptor agonists and routes of administration to elicit on-demand voiding of the bladder and bowel, as future therapy for individuals with spinal cord injury, was examined using a rat model. The current

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e75a3f7fad13bc19bda5fb99347a5b5
https://europepmc.org/articles/PMC5766413/

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Prokinetic effects of the neurokinin NK2 receptor agonist [Lys5,MeLeu9,Nle10]-NKA(4–10) on bladder and colorectal activity in minipigs

Autor: Daniel J. Ricca, Karl B. Thor, Nadia M.J. Rupniak, Mary A. Katofiasc, Edward C. Burgard, Lesley Marson

Publikováno v: Neuropeptides. 77:101956

The effects of the neurokinin NK2 receptor agonist [Lys5,MeLeu9,Nle10]-NKA(4–10) (LMN-NKA) on bladder and colorectal function were examined in minipigs. In anesthetized animals, subcutaneous (SC) administration of 30–100 μg/kg increased peak bla

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::777ad4e0dd995e29ee0238cb02f30fbe
https://doi.org/10.1016/j.npep.2019.101956

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