Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Mary Guaraldi"'
Publikováno v:
The Open Neurology Journal. 14:59-62
Background and Objective: Glutamate neurotoxicity is associated with a wide range of disorders and can impair synaptic function. Failure to clear extracellular glutamate fosters additional cycles and spread of regional hyperexcitation. Methods and Re
Publikováno v:
BioTechniques, Vol 52, Iss 3, Pp 177-182 (2012)
Multielectrode arrays (MEAs) are used for analysis of neuronal activity. Here we report two variations on commonly accepted techniques that increase the precision of extracellular electrical stimulation: (i) the use of a low-amplitude recorded sponta
Externí odkaz:
https://doaj.org/article/642c981dd5e341bf84c7c6e65449ace6
Autor:
Thomas B. Shea, Mary Guaraldi
Publikováno v:
The Open Neurology Journal
Objective: We examined genetic and dietary challenge on hippocampal oxidative damage. Mice expressing (ApoE+/+) or lacking apolipoprotein E (ApoE-/-) were maintained on a standard diet or a high fat /high cholesterol (challenge) diet for 11-31 weeks.
Autor:
Ming Yu, Paula Silva, Mary Guaraldi, Mikhail Kagan, Jody Bozek, Simon P. Robinson, Michael Azure, David C. Onthank
Publikováno v:
Nuclear Medicine and Biology. 40:682-688
Introduction Released sympathetic neurotransmitter norepinephrine (NE) in the heart is cleared by neuronal uptake-1 and extraneuronal uptake-2 transporters. Cardiac uptake-1 and -2 expression varies among species, but the uptake-1 is the primary tran
Autor:
Mary Guaraldi, Mikaela Therrien, Edward F. Boumil, Sangmook Lee, Thomas B. Shea, Rishel Vohnoutka
Publikováno v:
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. 55
The nervous system is composed of excitatory and inhibitory neurons. One major class of inhibitory neurons release the neurotransmitter γ-Aminobutyric acid (GABA). GABAergic inhibitory activity maintains the balance that is disrupted in conditions s
Autor:
Julia M. Nielsen, Jennifer McDonald, Dmitry Zuev, Megan Hayes, Eric Wexler, Joanne J. Bronson, Henry Wong, Yu-Wen Li, Nicholas J. Lodge, John E. Macor, Jeffrey A. Deskus, James E. Grace, Hong Huang, Gail K. Mattson, Mary Guaraldi, Derek J. Denhart, David C. Onthank, Vijay T. Ahuja, Heidi Dulac, Michael F. Parker, Larisa Zueva, Douglas D. Dischino, Ronald J. Mattson, Thaddeus F. Molski, Michael Azure, Jonathan L. Ditta, Richard A. Hartz
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6651-6655
Based on a favorable balance between CRF-R1 affinity, lipophilicity and metabolic stability, compound 10 was evaluated for potential development as PET radioligand. Compound [18F]10 was prepared with high radiochemical purity and showed promising bin
Publikováno v:
BioTechniques. 52:177-182
Multielectrode arrays (MEAs) are used for analysis of neuronal activity. Here we report two variations on commonly accepted techniques that increase the precision of extracellular electrical stimulation: (i) the use of a low-amplitude recorded sponta
Autor:
Mikhail Kagan, Carol Hui Hu, Thomas D. Harris, Megan Hayes, Padmaja Yalamanchili, Kelley Hanson, Ming Yu, Michael Azure, Ajay Purohit, Simon P. Robinson, Reinaldo Jones, Michael Cdebaca, Mary Guaraldi, Radeke Heike S, David S. Casebier
Publikováno v:
ACS Medicinal Chemistry Letters. 2:650-655
A series of potent and selective β1-adrenoreceptor ligands were identified (IC50 range, 0.04-0.25 nM; β1/β2 selectivity range, 65-450-fold), labeled with the PET radioisotope fluorine-18 and evaluated in normal Sprague-Dawley rats. Tissue distribu
Autor:
Mahesh Mistry, Padmaja Yalamanchili, Michael Azure, David S. Casebier, Ming Yu, Mikhail Kagan, Jody Bozek, Mary Guaraldi, Megan Hayes, Ajay Purohit, Jennifer McDonald, Radeke Heike S, Simon P. Robinson
Publikováno v:
European Journal of Nuclear Medicine and Molecular Imaging. 36:63-72
Myocardial extractions of mitochondria complex I (MC-I) inhibitors were high and well correlated with flow. This study assessed the potential of MC-I inhibitors to be developed as myocardial perfusion imaging (MPI) agents.RP1003, RP1004, and RP1005 r
Autor:
Robinson Simon P, Heike S. Radeke, Kelley Hanson, Yu Ming, Ajay Purohit, Mikhail Kagan, Padmaja Yalamanchili, Fran Su, Michael Azure, Megan Hayes, Richard Benetti, David Casebier, Mary Guaraldi
Publikováno v:
Journal of Medicinal Chemistry. 51:2954-2970
A series of fluorinated pyridazinone derivatives with IC50 values ranging from 8 to 4000 nM for the mitochondrial complex 1 (MC1) have been prepared. Structure-activity relationship (SAR) assessment indicated preference of the fluorine label to be in