Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Mary Giancarli"'
Autor:
William A. Schumacher, Jocelyne Guay, J.Eileen Bird, David A. Gordon, Mary Giancarli, Ruth R. Wexler, Pancras C. Wong, Mario Callejo, Michael M. Miller, Carol A. Watson, Julia Guy, Anne Marinier, Brad D. Maxwell, Ji Hua, E. Scott Priestley, Dietmar A. Seiffert, David G. Harden, Michel Bouvier, R. Michael Lawrence, Jacques Banville, Jing Yang, Nick J. Allegretto, Jeffrey S. Bostwick
Publikováno v:
Science translational medicine. 9(371)
Antiplatelet agents are proven efficacious treatments for cardiovascular and cerebrovascular diseases. However, the existing drugs are compromised by unwanted and sometimes life-threatening bleeding that limits drug usage or dosage. There is a substa
Autor:
Doree F. Sitkoff, Ming Chang, Carolyn A Cuff, Bang-Chi Chen, Cort S. Madsen, Xiaohong Yin, Saleem Ahmad, Evan B. Janovitz, Richard A. Reeves, Thomas Harrity, Lawrence J. Kennedy, Carol S. Ryan, Hossain Monshizadegan, Van Nguyen-Tran, Tong Li, Robert Zahler, Michael A. Blanar, Khehyong Ngu, Philip D. Stein, Rongan Zhang, Sharon N. Bisaha, Christine Huang, Joel C. Barrish, Eileen Bird, Debra Search, Celia D’Arienzo, Mary Giancarli, Robert Setters, Rulin Zhao, Jeffrey A. Robl, Xing Chen, Shaobin Zhuang
Publikováno v:
Journal of Medicinal Chemistry. 51:2722-2733
3-hydroxy-3-methylglutaryl coenzyme-A reductase (HMGR) inhibitors, more commonly known as statins, represent the gold standard in treating hypercholesterolemia. Although statins are regarded as generally safe, they are known to cause myopathy and, in
Autor:
Peter H. Gitlitz, Takao Kurihara, Mary Giancarli, Mark C. Kowala, Stephen K. Durham, Michele H. French, J.Eileen Bird, Maria T. Valentine, Darshana G. Pandya
Publikováno v:
Kidney International. 57:129-136
Increased severity of glomerulonephritis in C-C chemokine receptor 2 knockout mice. Background The C-C chemokine receptor 2 (CCR2) is expressed on monocytes and facilitates monocyte migration. CCR2 is a prominent receptor for monocyte chemoattractant
Autor:
Natesan Murugesan, Zhengxiang Gu, Philip D. Stein, Sharon Bisaha, Steve Spergel, Ravi Girotra, Ving G. Lee, John Lloyd, Raj N. Misra, Joan Schmidt, Arvind Mathur, Leslie Stratton, Yolanda F. Kelly, Eileen Bird, Tom Waldron, Eddie C.-K. Liu, Rongan Zhang, Helen Lee, Randy Serafino, Benoni Abboa-Offei, Parker Mathers, Mary Giancarli, Andrea Ann Seymour, Maria L. Webb, Suzanne Moreland, Joel C. Barrish, John T. Hunt
Publikováno v:
Journal of Medicinal Chemistry. 41:5198-5218
Substitution at the ortho position of N-(3,4-dimethyl-5-isoxazolyl) benzenesulfonamide led to the identification of the biphenylsulfonamides as a novel series of endothelin-A (ETA) selective antagonists. Appropriate substitutions on the pendant pheny
Publikováno v:
European Journal of Pharmacology. 294:183-189
While there is evidence to suggest that endothelin-1 is involved in regulation of kidney function and blood pressure, the importance of endothelin ETA receptors in this area has not been clearly defined. The novel, non-peptide endothelin ETA receptor
Autor:
Eileen Bird, Eddie C.-K. Liu, Maria L. Webb, Mary Giancarli, Jay Wasserman, Stephen K. Durham
Publikováno v:
Pharmacology. 50:9-23
Infusion (0.46 µmol/kg/min) of the endothelin (ET)-converting-enzyme inhibitor, phosphoramidon (P), protected function and structure after 30 min renal ischemia in rats more than treatment (5 µmol/kg/
Autor:
Frank A. Barbera, Dietmar A. Seiffert, Pancras C. Wong, J.Eileen Bird, Martin L. Ogletree, Mary Giancarli, Nick J. Allegretto, William A. Schumacher
Publikováno v:
Thrombosis research. 123(1)
Animal models of thrombosis and hemostasis are critical for target validation in pharmaceutical research. Guinea pig haemostatic mechanisms, such as the platelet thrombin receptor repertoire, resemble those of humans. Measuring the performance charac
Autor:
Natesan Murugesan, Mark H. Perrone, John E. Tellew, Mark C. Kowala, Jergen Baumann, Rose Ann F Baska, Yifan Yang, Zhengxiang Gu, Eileen Bird, Carol S. Ryan, Bridgette Kane, Kenneth E.J. Dickinson, Kenneth E. Carlson, Susan Arthur, Balkrushna C. Panchal, Sophie Beyer, Mary Giancarli, Pam Ferrer, Donglu Zhang, Leena Fadnis, John E. Macor, Hossain Monshizadegan, Joel C. Barrish, Nick C. Trippodo
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 309(1)
Angiotensin II and endothelin-1 activate their respective AT(1) and ET(A) receptors on vascular smooth muscle cells, producing vasoconstriction, and both peptides are implicated in the pathogenesis of essential hypertension. Angiotensin II potentiate
Autor:
Thomas E. Steinbacher, William A. Schumacher, J E Bird, C.H. Heran, Stephen K. Durham, Mary Giancarli, John R. Megill
Publikováno v:
Thrombosis research. 68(2)
An aspirin-sensitive model of arterial thrombosis suitable for rapid evaluation of antithrombotic drugs was developed and characterized in anesthetized rats. Carotid artery thrombi were formed in response to electrical stimulation and were occlusive
Autor:
Saleem Ahmad, Cort S. Madsen, Philip D. Stein, Evan Janovitz, Christine Huang, Khehyong Ngu, Sharon Bisaha, Lawrence J. Kennedy, Bang-Chi Chen, Rulin Zhao, Doree Sitkoff, Hossain Monshizadegan, Xiaohong Yin, Carol S. Ryan, Rongan Zhang, Mary Giancarli, Eileen Bird, Ming Chang, Xing Chen, Robert Setters
Publikováno v:
Journal of Medicinal Chemistry; Apr2008, Vol. 51 Issue 9, p2722-2733, 12p