Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mary, Sue Marty"'
Publikováno v:
Birth defects researchREFERENCES. 114(17)
The dynamics and complexities of in utero fetal development create significant challenges in transitioning from lab animal-centric developmental toxicity testing methods to assessment strategies based on new approach methodologies (NAMs). Nevertheles
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcba2891fcc6f474131f5191a950e995
https://pubmed.ncbi.nlm.nih.gov/36205106
https://pubmed.ncbi.nlm.nih.gov/36205106
Autor:
Masaaki Miyazawa, Raja S. Settivari, Matthew J. LeBaron, Mary Sue Marty, Hideyuki Mizumachi, Hitoshi Sakaguchi
Publikováno v:
Journal of Applied Toxicology. 41:915-927
The regulatory community is transitioning to the use of nonanimal methods for dermal sensitization assessments; however, some in vitro assays have limitations in their domain of applicability depending on the properties of chemicals being tested. Thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0ec2e50c7b2a3ff8a44261f1c221e5a
https://doi.org/10.1002/jat.4076
https://doi.org/10.1002/jat.4076
Publikováno v:
Applied In Vitro Toxicology. 5:187-195
Introduction: Reliable and effective predictions of hepatotoxicity resulting from repeated exposure to chemicals are of critical importance for the safety assessment of chemicals; however, in vitro...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fda4a41e29ed32d959dfaaad99c2ca6
https://doi.org/10.1089/aivt.2019.0008
https://doi.org/10.1089/aivt.2019.0008
Autor:
Mary Sue Marty, Sanjeeva J. Wijeyesakere, Daniel M. Wilson, Tyler R. Auernhammer, Amanda K. Parks, Dalila Kovacs
Publikováno v:
Applied In Vitro Toxicology. 5:196-204
Introduction: We are using big-data mining to develop computational models that predict whether previously uncharacterized compounds will or will not target important biological pathways. Mitochond...
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2384f35c40d933f736d246d358ac083
https://doi.org/10.1089/aivt.2019.0010
https://doi.org/10.1089/aivt.2019.0010
Autor:
Kevin M. Crofton, Arianna Bassan, Mamta Behl, Yaroslav G. Chushak, Ellen Fritsche, Jeffery M. Gearhart, Mary Sue Marty, Moiz Mumtaz, Manuela Pavan, Patricia Ruiz, Magdalini Sachana, Rajamani Selvam, Timothy J. Shafer, Lidiya Stavitskaya, David T. Szabo, Steven T. Szabo, Raymond R. Tice, Dan Wilson, David Woolley, Glenn J. Myatt
Publikováno v:
Comput Toxicol
Neurotoxicology is the study of adverse effects on the structure or function of the developing or mature adult nervous system following exposure to chemical, biological, or physical agents. The development of more informative alternative methods to a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f3ba94e6c068612369fa81e8dd2e651
https://doi.org/10.1016/j.comtox.2022.100223
https://doi.org/10.1016/j.comtox.2022.100223
Autor:
Anupama Kumar, Mary Sue Marty, Laurent Lagadic, Lisa A. Constantine, James P. Meador, Tamar I. Schwarz, Janice E. Chambers, Daniel B. Pickford, Amy Blankinship, Tim Verslycke, Werner Kloas
Publikováno v:
Integrated Environmental Assessment and Management. 13:317-330
For ecotoxicological risk assessment, endocrine disruptors require the establishment of an endocrine mode of action (MoA) with a plausible link to a population-relevant adverse effect. Current ecotoxicity test methods incorporate mostly apical endpoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f2cfff5c3edebe7cd30da67b139800d
https://doi.org/10.1002/ieam.1887
https://doi.org/10.1002/ieam.1887
Autor:
Mary E. Gilbert, R. Thomas Zoeller, Barbara A. Demeneix, Katie Paul Friedman, Kevin M. Crofton, Mary Sue Marty
Publikováno v:
OECD Series on Adverse Outcome Pathways.
This AOP describes one adverse outcome that may result from the inhibition of thyroperoxidase (TPO) during mammalian development. Chemical inhibition of TPO results in decreased thyroid hormone (TH) synthesis, and subsequent reduction in circulating
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d925a2c6664f722188de4e490bb62d6
https://doi.org/10.1787/ea5aa069-en
https://doi.org/10.1787/ea5aa069-en
Autor:
Mary Sue Marty, Richard A. Becker, Christopher J. Borgert, Lynn S. McCarty, Mark L. Hanson, Betsy D. Carlton, Raphael J. Witorsch, Kun Don Yi, Keith R. Solomon, Glen Van Der Kraak, Terry F. Quill, Patricia L. Kwiatkowski
Publikováno v:
Toxicological Sciences. 151:206-213
There is debate over whether the requirements of GLP are appropriate standards for evaluating the quality of toxicological data used to formulate regulations. A group promoting the importance of non-monotonic dose responses for endocrine disruptors c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2ebb65ed7adee7f01fa3d459e24dfc57
https://doi.org/10.1093/toxsci/kfw056
https://doi.org/10.1093/toxsci/kfw056
Publikováno v:
Computational Toxicology. 13:100119
The cholinergic nervous system plays a central role in biology and medicine and is comprised of the nicotinic (nAChR) and muscarinic receptors (mAChR) and acetylcholinesterase (AChE). Using ~20,000 compounds compiled from publicly available data, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cf3280d02c753010d05ffb25132c11e1
https://doi.org/10.1016/j.comtox.2020.100119
https://doi.org/10.1016/j.comtox.2020.100119
Autor:
Mary Sue Marty, Reza J. Rasoulpour, Sabitha Papineni, Katherine K. Coady, David L. Eisenbrandt, Lynn H. Pottenger
Publikováno v:
Regulatory Toxicology and Pharmacology. 72:405-422
Based on the exposure potential to humans and environment, pronamide was one of 52 chemicals on the first list evaluated under US EPA’s Endocrine Disruptor Screening Program (EDSP). The purpose of EDSP is to screen chemicals for their potential to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d7a22f857ddb266d3136ab9faf4483
https://doi.org/10.1016/j.yrtph.2015.03.016
https://doi.org/10.1016/j.yrtph.2015.03.016