Výsledky vyhledávání - "Mary, Requena"

Th22 cells are efficiently recruited in the gut by CCL28 as an alternative to CCL20 but do not compensate for the loss of Th17 cells in treated HIV-1-infected individuals

Autor: Guillaume Martin-Blondel, Jacques Izopet, Mary Requena, Bertrand Suc, Laurent Alric, Manon Nayrac, Nicolas Carrere, Pierre Delobel, Karl Barange, Claire Loiseau, Michelle Cazabat

Publikováno v: Mucosal Immunology
Mucosal Immunology, 2020, 14 (1), pp.219-228. ⟨10.1038/s41385-020-0286-6⟩
Mucosal Immunology, Nature Pub. Group, 2021, 14 (1), pp.219-228. ⟨10.1038/s41385-020-0286-6⟩

International audience; Gut CD4+ T cells are incompletely restored in most HIV-1-infected individuals on antiretroviral therapy, notably Th17 cells, a key subset in mucosal homeostasis. By contrast, gut Th22 cells are usually restored at normal frequ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7063cc54ac3d26c97d0c23435a80444c
https://ut3-toulouseinp.hal.science/hal-03157449

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Increased CXCR3+ T Cells Impairs Recruitment of T-Helper Type 17 Cells via Interferon γ and Interleukin 18 in the Small Intestine Mucosa During Treated HIV-1 Infection

Autor: Nicolas Carrere, Jacques Izopet, Bertrand Suc, Claire Loiseau, Michelle Cazabat, Pierre Delobel, Mary Requena, Manon Nayrac, Laurent Alric, M Mavigner, A L Iscache

Publikováno v: Journal of Infectious Diseases
Journal of Infectious Diseases, 2019, 220 (5), pp.830-840. ⟨10.1093/infdis/jiz123⟩
Journal of Infectious Diseases, Oxford University Press (OUP), 2019, 220 (5), pp.830-840. ⟨10.1093/infdis/jiz123⟩

The restoration of CD4+ T cells, especially T-helper type 17 (Th17) cells, remains incomplete in the gut mucosa of most human immunodeficiency virus type 1 (HIV-1)–infected individuals despite sustained antiretroviral therapy (ART). Herein, we repo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1bf1141fb4f0f9aada7cab65629d072a
https://ut3-toulouseinp.hal.science/hal-03355691

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Hepatitis E virus replication in human intestinal cells

Autor: Sébastien Lhomme, Olivier Marion, Nicolas Carrere, Florence Abravanel, Marion Migueres, Nassim Kamar, Mélanie Pucelle, Pierre Delobel, Martine Dubois, Bertrand Suc, Mary Requena, Manon Nayrac, Jean-Marie Peron, Jacques Izopet

Publikováno v: Gut
Gut, BMJ Publishing Group, 2020, 69 (5), pp.901-910. ⟨10.1136/gutjnl-2019-319004⟩

ObjectiveHepatitis E virus (HEV), one of the most common agent of acute hepatitis worldwide, is mainly transmitted enterically, via contaminated water for HEV genotypes 1 (HEV1) and HEV2, or by eating raw or undercooked infected meat for HEV genotype

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56835005e2457dc7227b0e4cfe93e33f
https://pubmed.ncbi.nlm.nih.gov/31915238

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Primary resistance of CCR5-tropic HIV-1 to maraviroc cannot be predicted by the V3 sequence

Autor: Jacques Izopet, Claire Loiseau, Bruno Marchou, Adrien Saliou, Stéphanie Raymond, Michelle Cazabat, Pierre Delobel, Patrice Massip, Lucile Coassin, Mary Requena

Publikováno v: Journal of Antimicrobial Chemotherapy. 68:2506-2514

Objectives: Resistance of HIV-1 to CCR5 antagonists can occur without coreceptor switching by mutations in envelope glycoproteins that enable virus entry using the inhibitor-bound form of CCR5. We investigated whether mutations in the V3 region of HI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04489d45db86cb8ddc0eb5f085b5a9d4
https://doi.org/10.1093/jac/dkt249

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Infection of Macrophages and Dendritic Cells with Primary R5-Tropic Human Immunodeficiency Virus Type 1 Inhibited by Natural Polyreactive Anti-CCR5 Antibodies Purified from Cervicovaginal Secretions

Autor: Gérard Grésenguet, Laurent Bélec, François-Xavier Mbopi Kéou, Mary Requena, Nadine Nasreddine, Jean De Dieu Longo, Srinivas V. Kaveri, Jobin Eslahpazir, Héla Saïdi, Hakim Hocini, Cédric Carbonneil, Hicham Bouhlal, Jérôme LeGoff, Mohammad-Ali Jenabian

Publikováno v: Clinical and Vaccine Immunology. 15:872-884

Heterosexual contact is the primary mode of human immunodeficiency virus (HIV) type 1 (HIV-1) transmission worldwide. The chemokine receptor CCR5 is the major coreceptor that is associated with the mucosal transmission of R5-tropic HIV-1 during sexua

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2aec176c249a3e24fe5fd856e7ca527
https://doi.org/10.1128/cvi.00463-07

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Inhibition of HIV-1 transmission in trans from dendritic cells to CD4+T lymphocytes by natural antibodies to the CRD domain of DC-SIGN purified from breast milk and intravenous immunoglobulins

Autor: Gérard Grésenguet, Laurent Bélec, Michel D. Kazatchkine, Nadine Nasreddine, Sylvie Aubry, Hakim Hocini, Mary Requena, Jean-Chrysostome Gody, Héla Saïdi, Hicham Bouhlal, Rafick-Pierre Sekaly

Publikováno v: Immunology. 123:508-518

The present study demonstrates that human breast milk and normal human polyclonal immunoglobulins purified from plasma [intravenous immunoglobulins (IVIg)] contain functional natural immunoglobulin A (IgA) and IgG antibodies directed against the carb

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1449eb031882822c63479da08073ca22
https://doi.org/10.1111/j.1365-2567.2007.02717.x

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No selection of CXCR4-using variants in cell reservoirs of dual-mixed HIV-infected patients on suppressive maraviroc therapy

Autor: Jacques Izopet, Stéphanie Raymond, Michelle Cazabat, Florence Nicot, Pierre Delobel, Lise Cuzin, Mary Requena, Nicolas Jeanne, Romain Carcenac

Publikováno v: AIDS (London, England). 30(6)

We used ultradeep sequencing to investigate the evolution of the frequency of CXCR4-using viruses in the peripheral blood mononuclear cells of 22 patients infected with both CCR5 and CXCR4-using viruses treated with the CCR5 antagonist maraviroc for

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ae51fb73ee962a7141d9c9215c8307d
https://pubmed.ncbi.nlm.nih.gov/26752281

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Opsonization of HIV with Complement Enhances Infection of Dendritic Cells and Viral Transfer to CD4 T Cells in a CR3 and DC-SIGN-Dependent Manner

Autor: Jérôme LeGoff, Nadine Nasreddine, Nicolas Chomont, Michel D. Kazatchkine, Laurent Bélec, Héla Saïdi, Mary Requena, Hakim Hocini, Hicham Bouhlal

Publikováno v: The Journal of Immunology. 178:1086-1095

In the present study, we demonstrated that opsonization of primary HIV-1 with human complement enhances infection of immature monocyte-derived dendritic cells (iDC) and transmission in trans of HIV to autologous CD4+ T lymphocytes. Infection of iDC b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae56d298b369de1038b536dbf1b7d393
https://doi.org/10.4049/jimmunol.178.2.1086

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CCR6(-) regulatory T cells blunt the restoration of gut Th17 cells along the CCR6-CCL20 axis in treated HIV-1-infected individuals

Autor: Jacques Izopet, Bruno Marchou, Bertrand Suc, Laurent Alric, Nicolas Carrere, Mary Requena, M Mavigner, Karl Barange, Pierre Delobel, Claire Loiseau, Michelle Cazabat, Patrice Massip

Publikováno v: Mucosal Immunology
Mucosal Immunology, 2016, 9 (5), pp.1137-1150. ⟨10.1038/mi.2016.7⟩
Mucosal Immunology, Nature Pub. Group, 2016, 9 (5), pp.1137-1150. ⟨10.1038/mi.2016.7⟩

International audience; The gut CD4(+) T cells, particularly the T helper type 17 (Th17) subset, are not completely restored in most HIV-1-infected individuals despite combined antiretroviral therapy, when initiated at the chronic phase of infection.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13fb6dd740045fd76854db35666169ce
https://pubmed.ncbi.nlm.nih.gov/26883727

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