Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Marwan Maalouf"'
Publikováno v:
PLoS ONE, Vol 4, Iss 7, p e6235 (2009)
Mouse models with physiological and behavioral differences attributable to differential plasticity of hippocampal and amygdalar neuronal networks are rare. We previously generated ataxin-2 (Atxn2) knockout mice and demonstrated that these animals lac
Externí odkaz:
https://doaj.org/article/f3b1cf90e6394fd7ae31db39a0f5e180
Publikováno v:
Current Alzheimer Research. 11:283-290
Apolipoprotein E e4 allele (ApoE4) has been associated with increased risk of sporadic Alzheimer's disease (AD) and of conversion from mild cognitive impairment to AD. But the underlying mechanism of ApoE4 affecting brain atrophy and cognition is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23360e4034c5d0dc52e2e6dca5613cc9
https://doi.org/10.2174/156720501103140329220007
https://doi.org/10.2174/156720501103140329220007
Autor:
Dharshaun Turner, Chen Wu, Jian-Xin Shen, Lu-Yao Ma, Jie Wu, Makoto Wakui, Ryoichi Kimura, Marwan Maalouf, Kevin Ellsworth
Publikováno v:
CNS Neuroscience & Therapeutics. 18:641-646
SUMMARY Aims: To evaluate the acute effects of the mitochondrial complex I inhibitor rotenone on rat hippocampal synaptic plasticity. Methods: Electrophysiological field potential recordings were used to measure basal synaptic transmission and synapt
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cfa373388d6163c87c97b5b79b499060
https://doi.org/10.1111/j.1755-5949.2012.00337.x
https://doi.org/10.1111/j.1755-5949.2012.00337.x
Publikováno v:
Brain Research Reviews. 59:293-315
Both calorie restriction and the ketogenic diet possess broad therapeutic potential in various clinical settings and in various animal models of neurological disease. Following calorie restriction or consumption of a ketogenic diet, there is notable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f55f7ca7f208bf03c1bce8f302e89ed8
https://doi.org/10.1016/j.brainresrev.2008.09.002
https://doi.org/10.1016/j.brainresrev.2008.09.002
Autor:
Jong M. Rho, Marwan Maalouf
Publikováno v:
Journal of Neuroscience Research. 86:3322-3330
Previous studies have shown that ketone bodies (KB) exert antioxidant effects in experimental models of neurological disease. In the present study, we explored the effects of the KB acetoacetate (ACA) and beta-hydroxybutyrate (BHB) on impairment of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e8e40cb793f708fdaaa47cd1a005a242
https://doi.org/10.1002/jnr.21782
https://doi.org/10.1002/jnr.21782
Autor:
Johannes van Brederode, Marwan Maalouf, Timothy A. Simeone, Laurie M. Davis, Patrick G. Sullivan, Jong M. Rho, Do Young Kim
Publikováno v:
Journal of Neurochemistry. 101:1316-1326
Ketone bodies (KB) have been shown to prevent neurodegeneration in models of Parkinson's and Alzheimer's diseases, but the mechanisms underlying these effects remain unclear. One possibility is that KB may exert antioxidant activity. In the current s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd00922347f22d53ee1b7e70a1da2b7c
https://doi.org/10.1111/j.1471-4159.2007.04483.x
https://doi.org/10.1111/j.1471-4159.2007.04483.x
Autor:
Jie Wu, Turner Dharshaun, Marwan Maalouf, Felix E. Schweizer, Ming Gao, Julian P. Whitelegge, Jun Xiang Yin, Christopher M. Ryan, Pengcheng Han, David Eisenberg, Minglei Zhao, Eric M. Reiman, Jiong Shi
Publikováno v:
Neurobiology of aging. 39
Sporadic Alzheimer's disease (AD) is responsible for 60%-80% of dementia cases, and the most opportune time for preventive intervention is in the earliest stage of its preclinical phase. As traditional mitochondrial energy substrates, ketone bodies (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f3b9ba58e1837fd01f2814a6cd41c51
https://pubmed.ncbi.nlm.nih.gov/26923399
https://pubmed.ncbi.nlm.nih.gov/26923399
Autor:
Zhiwei Tang, Eric M. Reiman, Junxiang Yin, Marwan Maalouf, Jiong Shi, Pengcheng Han, Thomas G. Beach
Publikováno v:
Neurobiology of aging. 35(9)
Pituitary adenylate cyclase activating polypeptide (PACAP) is a neurotrophin. However, its role in human Alzheimer's disease (AD) is largely unknown. We examined PACAP expression in postmortem human AD and triple transgenic mouse (3xTG, Psen1/APPSwe/
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e42ea44adf36e5b3b7615ec86288578
https://pubmed.ncbi.nlm.nih.gov/24726470
https://pubmed.ncbi.nlm.nih.gov/24726470
Autor:
Junxiang, Yin, Gregory H, Turner, Stephen W, Coons, Marwan, Maalouf, Eric M, Reiman, Jiong, Shi
Publikováno v:
Current Alzheimer research. 11(3)
Apolipoprotein E ε4 allele (ApoE4) has been associated with increased risk of sporadic Alzheimer's disease (AD) and of conversion from mild cognitive impairment to AD. But the underlying mechanism of ApoE4 affecting brain atrophy and cognition is no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e959c6f257d0bdb13d5993e110db8002
https://pubmed.ncbi.nlm.nih.gov/24694076
https://pubmed.ncbi.nlm.nih.gov/24694076
Publikováno v:
Alzheimer's & Dementia. 9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c66002c014791cc7c199c316a3f03786
https://doi.org/10.1016/j.jalz.2013.05.672
https://doi.org/10.1016/j.jalz.2013.05.672