Targeting the IL-17/IFN-γ axis as a potential new clinical therapy for type 1 diabetes

Autor: Marwaha, Ashish K., Tan, Sara, Dutz, Jan P.

Publikováno v: In Clinical Immunology September 2014 154(1):84-89

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A phase 1b open-label dose-finding study of ustekinumab in young adults with type 1 diabetes.

Autor: Marwaha AK; Department of Medical Genetics, University of Calgary, Cumming School of Medicine, Calgary, Alberta, Canada., Chow S; Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada., Pesenacker AM; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada., Cook L; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Sun A; Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada., Long SA; Benaroya Research Institute at Virginia Mason, Translational Research Program, Seattle, WA, USA., Yang JHM; Department of Immunobiology, King's College London, London, UK., Ward-Hartstonge KA; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada., Williams E; Department of Immunobiology, King's College London, London, UK., Domingo-Vila C; Department of Immunobiology, King's College London, London, UK., Halani K; Emmes Canada, Burnaby, British Columbia, Canada., Harris KM; Immune Tolerance Network, Bethesda, MD, USA., Tree TIM; Department of Immunobiology, King's College London, London, UK., Levings MK; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.; Department of Surgery, University of British Columbia, Vancouver, British Columbia, Canada., Elliott T; Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada.; BCDiabetes, Vancouver, British Columbia, Canada., Tan R; Department of Pathology, Sidra Medicine and Weill Cornell Medicine, Doha, Qatar.; Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada., Dutz JP; Department of Dermatology and Skin Science, University of British Columbia, Vancouver, British Columbia, Canada.; BC Children's Hospital Research Institute, Vancouver, British Columbia, Canada.

Publikováno v: Immunotherapy advances [Immunother Adv] 2021 Nov 13; Vol. 2 (1), pp. ltab022. Date of Electronic Publication: 2021 Nov 13 (Print Publication: 2022).