Zobrazeno 1 - 10 of 241 pro vyhledávání: '"Marwa M. Abu Serie"'
1
Akademický článek
New 1,2,4-oxadiazole derivatives as potential multifunctional agents for the treatment of Alzheimer’s disease: design, synthesis, and biological evaluation
Autor: Mohammed Salah Ayoup, Mariam Ghanem, Hamida Abdel-Hamid, Marwa M. Abu-Serie, Aliaa Masoud, Doaa A. Ghareeb, Mohammed B. Hawsawi, Amr Sonousi, Asmaa E. Kassab
Publikováno v: BMC Chemistry, Vol 18, Iss 1, Pp 1-15 (2024)
Abstract A series of new 1,2,4-oxadiazole-based derivatives were synthesized and evaluated for their anti-AD potential. The results revealed that eleven compounds (1b, 2a-c, 3b, 4a-c, and 5a-c) exhibited excellent inhibitory potential against AChE, w
Externí odkaz: https://doaj.org/article/dc68b8e4e3bd464b9dddc323540f7db5
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4
Akademický článek
Non-small cell lung cancer sensitisation to platinum chemotherapy via new thiazole-triazole hybrids acting as dual T-type CCB/MMP-9 inhibitors
Autor: Hassan Gamal, Khadiga A. Ismail, A-Mohsen M. E. Omar, Mohamed Teleb, Marwa M. Abu-Serie, Sun Huang, Abdalla S. Abdelsattar, Gerald W. Zamponi, Hesham Fahmy
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
Cisplatin remains the unchallenged standard therapy for NSCLC. However, it is not completely curative due to drug resistance and oxidative stress-induced toxicity. Drug resistance is linked to overexpression of matrix metalloproteinases (MMPs) and ab
Externí odkaz: https://doaj.org/article/5539ecc082aa403a859e84b2104d936f
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5
Akademický článek
Imparting aromaticity to 2-pyridone derivatives by O-alkylation resulted in new competitive and non-competitive PIM-1 kinase inhibitors with caspase-activated apoptosis
Autor: Marwa E. Abdelaziz, Mostafa M. M. El-Miligy, Salwa M. Fahmy, Marwa M. Abu-Serie, Aly A. Hazzaa, Mona A. Mahran
Publikováno v: Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 39, Iss 1 (2024)
AbstractNew aromatic O-alkyl pyridine derivatives were designed and synthesised as Proviral Integration Moloney (PIM)-1 kinase inhibitors. 4c and 4f showed potent in vitro anticancer activity against NFS-60, HepG-2, PC-3, and Caco-2 cell lines and lo
Externí odkaz: https://doaj.org/article/e162c88d829d4fc1b977203714ab0d09
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6
Akademický článek
Superior cuproptotic efficacy of diethyldithiocarbamate-Cu4O3 nanoparticles over diethyldithiocarbamate-Cu2O nanoparticles in metastatic hepatocellular carcinoma
Autor: Marwa M. Abu-Serie, Assem Barakat, Sherif Ramadan, Noha Hassan Habashy
Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)
Metastatic hepatocellular carcinoma (HC) is a serious health concern. The stemness of cancer stem cells (CSCs) is a key driver for HC tumorigenesis, apoptotic resistance, and metastasis, and functional mitochondria are critical for its maintenance. C
Externí odkaz: https://doaj.org/article/b4240be95a954bac883d8c7addebe841
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7
Akademický článek
A comparative study on the protective effects of cuminaldehyde, thymoquinone, and gallic acid against carbon tetrachloride-induced pulmonary and renal toxicity in rats by affecting ROS and NF-κB signaling
Autor: Nadia Z. Shaban, Lamiaa A. El Swify, Marwa M. Abu-Serie, Adham M. Maher, Noha H. Habashy
Publikováno v: Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116692- (2024)
CCl4 toxicity is a fatal condition that can cause numerous organ dysfunctions. We evaluated and compared the protective effects of cuminaldehyde (CuA), thymoquinone (TQ), and gallic acid (GA) on CCl4-induced pulmonary and renal toxicity in rats. The
Externí odkaz: https://doaj.org/article/ab099dd623e147bfb3fa8d2ed71458fa
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8
Akademický článek
Seedless black Vitis vinifera polyphenols suppress hepatocellular carcinoma in vitro and in vivo by targeting apoptosis, cancer stem cells, and proliferation
Autor: Nadia Z. Shaban, Walaa A. Hegazy, Marwa M. Abu-Serie, Iman M. Talaat, Olfat M. Awad, Noha H. Habashy
Publikováno v: Biomedicine & Pharmacotherapy, Vol 175, Iss , Pp 116638- (2024)
Hepatocellular carcinoma (HCC) is an aggressive tumor and one of the most challenging cancers to treat. Here, we evaluated the in vitro and in vivo ameliorating impacts of seedless black Vitis vinifera (VV) polyphenols on HCC. Following the preparati
Externí odkaz: https://doaj.org/article/af9ab6993eee4045a1da6d337de07af4
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9
Akademický článek
Nanofibers based on zein protein loaded with tungsten oxide for cancer therapy: fabrication, characterization and in vitro evaluation
Autor: Gomaa El Fawal, Ashraf M. Omar, Marwa M. Abu-Serie
Publikováno v: Scientific Reports, Vol 13, Iss 1, Pp 1-11 (2023)
Abstract Plant proteins have become attractive for biomedical applications such as wound dressing and drug delivery. In this research, nanofibers from pristine zein (plant protein) and zein loaded with tungsten oxide (WO3) were prepared (WO3@zein) us
Externí odkaz: https://doaj.org/article/50d9b8afbf994444be1814b58ce29d28
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10
Akademický článek
Diethyldithiocarbamate-ferrous oxide nanoparticles inhibit human and mouse glioblastoma stemness: aldehyde dehydrogenase 1A1 suppression and ferroptosis induction
Autor: Marwa M. Abu-Serie, Satoru Osuka, Lamiaa A. Heikal, Mohamed Teleb, Assem Barakat, Vikas Dudeja
Publikováno v: Frontiers in Pharmacology, Vol 15 (2024)
The development of effective therapy for eradicating glioblastoma stem cells remains a major challenge due to their aggressive growth, chemoresistance and radioresistance which are mainly conferred by aldehyde dehydrogenase (ALDH)1A1. The latter is t
Externí odkaz: https://doaj.org/article/4359582bb7184498b85805cdf85ca513
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