Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Marwa H. El-Wakil"'
Autor:
Mayada M. Toughan, Ahmed M. M. El-Saghier, Marwa H. El-Wakil, Sherine N. Khattab, Hosam H. Khalil
Publikováno v:
ChemistrySelect. 5:6556-6564
Autor:
Marwa H. El-Wakil, Mohamed Teleb
Publikováno v:
Bioorganic chemistry. 116
Novel 1,3,4-thiadiazolo[2,3-c]-1,2,4-triazin-4-one derivatives 3a-e, 4a-f and 5a-f were designed as Type I c-Met kinase inhibitors based on scaffold hopping of our previous Type II c-Met kinase lead. Target compounds were then synthesized under the g
Autor:
Sun Huang, Gerald W. Zamponi, Hesham Fahmy, Marwa M. Abu-Serie, Marwa H. El-Wakil, Mohamed Teleb
Publikováno v:
Bioorganic chemistry. 115
T-type calcium channels are considered potential drug targets to combat cancer. Combining T-type calcium channel blockers with conventional chemotherapy drugs represents a promising strategy towards successful cancer treatment. From this perspective,
Publikováno v:
Bioorganic chemistry. 113
Drug repurposing has gained much attention as a cost-effective strategy that plays an exquisite role in identifying undescribed biological activities in clinical drugs. In the present work, we report the repurposing of the antibacterial drug nitrofur
Publikováno v:
Bioorganic Chemistry. 76:154-165
The receptor tyrosine kinase c-Met is an attractive target for therapeutic treatment of cancers nowadays. Herein we describe the design and synthesis of a novel series of 1,2,4-triazine derivatives based on our lead NCI 748494/1, possessing different
Publikováno v:
Bioorganic Chemistry. 73:154-169
In silico target fishing approach using PharmMapper server identified c-Met kinase as the selective target for our previously synthesized compound NCI 748494/1. This approach was validated by in vitro kinase assay which showed that NCI 748494/1 posse
Autor:
Sherine N. Khattab, Ahmed A. Soffar, Nefertiti El-Nikhely, Amira F. El-Yazbi, Marwa H. El-Wakil, Hosam H. Khalil
Publikováno v:
Bioorganic Chemistry. 105:104393
In the pursuit of new compounds for co-treatment to enhance the anticancer efficacy of cisplatin against lung adenocarcinoma, a series of chalcone-tethered 1,3,5-triazines was designed and synthesized. MTT assay was used to evaluate the anticancer ac
Autor:
K. A. Ismail, Amira F. El-Yazbi, Ibrahim M. Labouta, Marwa H. El-Wakil, Hayam M. A. Ashour, Mounir A. Khalil
Publikováno v:
Bioorganic Chemistry. 90:103089
New series of furan–thiazole hybrids (3a-f), thiazolo[2,3-c]-1,2,4-triazines (4a-f), their bioisosteres 1,3,4-thiadiazolo[2,3-c]-1,2,4-triazines (8a-d) and 1,2,4-triazino[4,3-b]-1,2,4-triazines (13a-e) were designed, synthesized and evaluated for t
Autor:
Nesreen S. Haiba, Adnan A. Bekhit, Sherine N. Khattab, Hosam H. Khalil, Marwa H. El-Wakil, Mohamed Abdel Moniem
Publikováno v:
Bioorganic Chemistry. 89:103013
Three novel series of s-triazine derivatives, including thirty-five new compounds 2a-d, 3a-3p, 4b-d, 5b-d, 6d-6d, and 7a-7f were synthesized comprising a diversity of substituents based on the structure of Astrazeneca arylaminotriazine DNA gyrase B i
Publikováno v:
Medicinal Chemistry Research. 22:1909-1924
The synthesis of some new (E)-6-[2-(furan-2-yl)ethenyl]-1,2,4-triazin-5-ones directly linked to either pyrazole, pyrazoline, pyrazolidine counterparts, or to substituted thio and hydrazono functionalities is described. Six of the newly synthesized co