Zobrazeno 1 - 10
of 103
pro vyhledávání: '"Marvin T, Nieman"'
Autor:
Frederik Denorme, Nicole D. Armstrong, Michelle L. Stoller, Irina Portier, Emilia A. Tugolukova, Rikki M. Tanner, Emilie Montenont, Seema Bhatlekar, Mark Cody, John L. Rustad, Abigail Ajanel, Neal D. Tolley, Darian C. Murray, Julie L. Boyle, Marvin T. Nieman, Steven E. McKenzie, Christian Con Yost, Leslie A. Lange, Mary Cushman, Marguerite R. Irvin, Paul F. Bray, Robert A. Campbell
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 18 (2023)
Protease-activated receptor 4 (PAR4) (gene F2RL3) harbors a functional dimorphism, rs773902 A/G (encoding Thr120/Ala120, respectively) and is associated with greater platelet aggregation. The A allele frequency is more common in Black individuals, an
Externí odkaz:
https://doaj.org/article/d092af6b93764c9897fa3db88dadf434
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 1, Pp 17-26 (2021)
Abstract Proteases are important regulators of cell behavior, survival, and apoptosis. They communicate to cells directly through a special class of G‐protein–coupled receptors known as protease‐activated receptors (PARs). N‐terminal PAR prot
Externí odkaz:
https://doaj.org/article/4461aabe6fad4dfa97ea5cfdc71a46f6
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 1, Pp 104-110 (2021)
Abstract Background Protease‐activated receptor (PAR) 1 and PAR4 are key thrombin signal mediators for human platelet activation and aggregation in response to vascular injury. They are primarily activated by thrombin cleavage of the N‐terminus t
Externí odkaz:
https://doaj.org/article/7757ef8195e54f378b868564fede0ed4
Autor:
Emma G. Bouck, Maria de laFuente, Elizabeth R. Zunica, Wei Li, Michele M. Mumaw, Marvin T. Nieman
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 5, Iss 1, Pp 125-131 (2021)
Abstract Background Platelet adhesion is the critical process mediating stable thrombus formation. Previous reports of cadherin‐6 on human platelets have demonstrated its role in platelet aggregation and thrombus formation. Objectives We aimed to f
Externí odkaz:
https://doaj.org/article/e1858e91bc914b1f96ae3f1bec6abab5
Autor:
Mary Cushman, Geoffrey D. Barnes, Mark A. Creager, Jose A. Diaz, Peter K. Henke, Kellie R. Machlus, Marvin T. Nieman, Alisa S. Wolberg, the American Heart Association Council on Peripheral Vascular Disease, Council on Arteriosclerosis, Thrombosis, and Vascular Biology, Council on Cardiovascular and Stroke Nursing, Council on Clinical Cardiology, Council on Epidemiology and Prevention, and International Society on Thrombosis and Haemostasis (ISTH)
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 4, Iss 5, Pp 714-721 (2020)
Abstract Venous thromboembolism (VTE) is a major cause of morbidity and mortality. The impact of the Surgeon General’s Call to Action in 2008 has been lower than expected given the public health impact of this disease. This scientific statement hig
Externí odkaz:
https://doaj.org/article/5b297e2f42424ff09fdd7057c96e572f
Autor:
Monica M. Montano, I-Ju Yeh, Yinghua Chen, Chris Hernandez, Janna G. Kiselar, Maria de la Fuente, Adriane M. Lawes, Marvin T. Nieman, Philip D. Kiser, James Jacobberger, Agata A. Exner, Matthew C. Lawes
Publikováno v:
Breast Cancer Research, Vol 21, Iss 1, Pp 1-15 (2019)
Abstract Background The tumor suppressor actions of hexamethylene bis-acetamide (HMBA)-inducible protein 1 (HEXIM1) in the breast, prostate, melanomas, and AML have been reported by our group and others. Increased HEXIM1 expression caused differentia
Externí odkaz:
https://doaj.org/article/823d9e4c6c704698b65e256f03e474fe
Autor:
Sandip Basak, Yvonne Gicheru, Amrita Samanta, Sudheer Kumar Molugu, Wei Huang, Maria la de Fuente, Taylor Hughes, Derek J. Taylor, Marvin T. Nieman, Vera Moiseenkova-Bell, Sudha Chakrapani
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-10 (2018)
Serotonin receptor (5-HT3AR), a pentameric ligand-gated ion channel, regulates numerous gastrointestinal functions. Here the authors provide a cryo-electron microscopic structure from the full-length 5-HT3AR in the apo-state which corresponds to a re
Externí odkaz:
https://doaj.org/article/1bb90dff34df4dafbd0d19b7edd091cb
Autor:
Michelle A. Cruz, Dillon Bohinc, Elizabeth A. Andraska, Jurgis Alvikas, Shruti Raghunathan, Nicole A. Masters, Nadine D. van Kleef, Kara L. Bane, Kathryn Hart, Kathryn Medrow, Michael Sun, Haitao Liu, Shannon Haldeman, Ankush Banerjee, Emma M. Lessieur, Kara Hageman, Agharnan Gandhi, Maria de la Fuente, Marvin T. Nieman, Timothy S. Kern, Coen Maas, Steven de Maat, Keith B. Neeves, Matthew D. Neal, Anirban Sen Gupta, Evi X. Stavrou
Publikováno v:
Nature nanotechnology, vol 17, iss 9
Nat Nanotechnol
Nat Nanotechnol
Targeted drug delivery to disease-associated activated neutrophils can provide novel therapeutic opportunities while avoiding systemic effects on immune functions. We created a nanomedicine platform that uniquely utilizes an α(1)-antitrypsin-derived
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c831df7b71934cc4f40ea9c29b8cba2
https://doi.org/10.1038/s41565-022-01161-w
https://doi.org/10.1038/s41565-022-01161-w
Publikováno v:
Frontiers in Medicine, Vol 6 (2019)
Externí odkaz:
https://doaj.org/article/ca9c0b52a2ef49a5adb69753076e7dfd
Autor:
Michelle L. Stoller, Indranil Basak, Frederik Denorme, Jesse W. Rowley, James Alsobrooks, Krishna Parsawar, Marvin T. Nieman, Christian Con Yost, Justin R. Hamilton, Paul F. Bray, Robert A. Campbell
Publikováno v:
Blood Advances. 6:2303-2308
Platelet-neutrophil interactions regulate ischemic vascular injury. Platelets are activated by serine proteases that cleave protease-activated receptor (PAR) amino termini, resulting in an activating tethered ligand. Neutrophils release cathepsin G (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::070cb5c9a788863dd522f32d7092a30a
https://doi.org/10.1182/bloodadvances.2021006133
https://doi.org/10.1182/bloodadvances.2021006133